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RISS 인기검색어
- 검색키워드
- 저자 : Alireza Ghannadi (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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An Investigation of the Analgesic and Anti-Inflammatory Effects of Nigella sativa Seed Polyphenols
Alireza Ghannadi,Valiollah Hajhashemi,Hadi Jafarabadi 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Extracts obtained from the seeds of Nigella sativaare used as a spice or remedy for the treatment of variousinflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphe-nols. N. sativaseed polyphenols were prepared, and analgesic and anti-inflammatory effects were studied in mice and rats us-ing the acetic acid-induced writhing, formalin, light tail flick, carrageenan-induced paw edema, and croton oil-induced earedema tests. In the acetic acid-induced writhing test, oral administration of N. sativa polyphenols (NSP) decreased the num-ber of abdominal constrictions. Both oral and intraperitoneal administration of NSP significantly suppressed in a dose-de-pendent manner the nociceptive response in the early and late phases of the formalin test, and the effect on the late phase wasmore pronounced. Pretreatment with naloxone failed to reverse the analgesic activity of NSP in this test. NSP did not pro-duce a significant analgesia in the light tail flick test in mice. Oral administration of NSP did not produce a significant re-duction in carrageenan-induced paw edema. However, when injected intraperitoneally, NSP inhibited paw edema in a dose-dependent manner. NSP when applied topically failed to reduce croton oil-induced ear edema. These results suggest that NSPhave analgesic and anti-inflammatory effects. The lack of analgesic effect of NSP in the light tail flick test and also the fail-ure of naloxone to reverse the analgesia in the formalin test reveal that mechanisms other than stimulation of opioid recep-tors are involved.
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Hypolipidemic Activity of Allium porrum L. in Cholesterol-Fed Rabbits
Ahmad Movahedian,Hojjat Sadeghi,Alireza Ghannadi,Mahin Gharavi,Sepideh Azarpajooh 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
Allium porrum L. is a herbaceous plant from the Liliaceae family and has been widely used in Persian foodsas a flavor component and in Iranian traditional medicine as an anti-atherogenic remedy. The present investigation was un-dertaken to evaluate the antihypercholesterolemic effect of a hydroalcoholic extract of A. porrum L. bulbs. Rabbits were di-vided into five groupscontrol, hypercholesterolemic control, and three treatment groups (hypercholesterolemic diet. 250,500, or 1,000 mg/kg of body weight of extract, respectively)and were fed for 12 weeks. Blood samples were obtained toanalyze plasma cholesterol, triglycerides, and low-density lipoprotein (LDL), very LDL, and high-density lipoprotein (HDL)cholesterol. Body weight increased in all groups throughout the treatment without significant differences among them. Plasmatotal cholesterol increased with respect to the control in the positive control group at the end of the treatment. Plasma totalcholesterol decreased in all groups treated with A. porrumextract in a dose-dependent fashion. Changes in the distribution ofcholesterol in HDL or LDL were found, and LDL cholesterol decreased significantly in all of the groups treated with A. por-rumextract with respect to the hypercholesterolemic group. Thus, these findings indicate that this plant may be useful for thetreatment of hypercholesterolemia.
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