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RISS 인기검색어
- 검색키워드
- 저자 : Aline C. Santos (검색결과 4 건)
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Rodrigo de Almeida Vaucher,Janice Luehring Giongo,Leandro Perger Bolzan,Marcos Saldanha Côrrea,Viviane Pedroso Fausto,Camilla Filippi dos Santos Alves,Leonardo Quintana Soares Lopes,Aline Augusti Boli 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.2
Antimicrobial activity of Amazonian oils Andiroba and Copaiba against Paenibacillus larvae has been recently determined, indicating their potential use for the control of American Foulbrood Disease (AFB), but the use of essential oils in the environment still represents a challenge. The oils present several volatile elements in its composition, such high volatility being the cause of a sharp decline in antimicrobial activity. In this context the nanostructuration of these amazon oils may decrease the volatile characteristic of such products. The following research aimed to evaluate the activity of nanoemulsions prepared with Andiroba and Copaiba oils against Paenibacillus species. The toxicity of nanoemulsions has also been investigated with larvae and adult worker bees. Nanoemulsions (NE1, 10% Andiroba oil; NE2, 10% Copaiba oil; and NE3, 10% medium-chain triglyceride as negative control) were prepared in a high pressure homogenizer. The particle sizes were determined as 192, 211, and 178 nm for NE1, NE2, and NE3, respectively. The z potential values were −56.4, −47.1, and −27.2, respectively. NE1 and NE2 showed minimal inhibitory concentration (MIC) values lower than 0.39% for most Paenibacillus species tested. None of the strains were inhibited by negative control NE3. The timeresponse effect of the nanoemulsions has been tested on P. larvae ATCC9545, resulting in a decrease in the number of viable cells to less than 1 log CFU/ml for NE1. The nanoemulsion NE1 showed a significant toxic effect for the larvae (26% mortality) when compared with NE2 (13%) and NE3 (7%). The toxic effect of nanoemulsions has also been evaluated for 72 h in adult worker bees and low mortality rate was only observed for the NE1 treatment (8.3%). This study shows for the first time that nanoemulsions of Copaiba oil can be a potential candidate for the treatment or prevention of AFB.
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Assessment of Bone Mineral Density of Patients with Spinocerebellar Ataxia Type 3
Aline Maria Santos Farias,Simone Appenzeller,Marcondes C França Jr.,Alberto RM Martinez,Elba E Etchebehere,Thiago F Souza,Allan O Santos 대한파킨슨병및이상운동질환학회 2019 Journal Of Movement Disorders Vol.12 No.1
Objective To evaluate whether less pulsatile levodopa therapy (LPT) can reduce the development of levodopa-induced dyskinesia (LID). Methods This is a retrospective cohort study of patients with Parkinson’s disease at the movement disorders clinic of Medstar Washington Hospital Center. The study was not blinded or randomized. Patients were seen between August 2002 and August 2018. During these years, we treated patients with less pulsatile (6 doses daily) levodopa treatment to reduce LID. Occurrence of LID was recorded. Results Ninety-five patients with Parkinson’s disease taking levodopa were divided into two groups: 1) patients who were initially managed on LPT or who switched from traditional therapy (TT) (n = 61) (mean disease duration: 7.7 ± 4.8 years, mean levodopa duration: 5.6 ± 4.5 years and mean observation time: 4.3 ± 3.4 years), and 2) patients on TT throughout the observation period or until they developed dyskinesia (n = 34) (mean disease duration: 8.3 ± 3.8 years, mean levodopa duration: 6.2 ± 4.2 years and mean observation time: 4.1 ± 3.4 years). Three of the 61 LPT patients developed dyskinesia during the observation period. One of the patients developed dyskinesia after being switched to pulsatile doses by another doctor. In the other two, dyskinesia was minimal. In contrast to this 4.9% cumulative incidence, dyskinesia occurred in 50% (17/34) of TT patients, an incidence similar to that in published data (p < 0.001). Conclusion Less pulsatile levodopa with 6 daily doses was associated with a low incidence of LID. Further study of this method of treatment is warranted.
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Andreia Volpato,Dilmar Baretta,Talyta Zortéa,Gabriela Campigotto,Patricia Glombowsky,Roberto C.V. Santos,Priscilla M. Quatrin,Aline F. Ourique,Matheus D. Baldissera,Lenita M. Stefani,Aleksandro S. Da 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.4
The aim of this study was to evaluate the in vitro susceptibility of larva and adult forms of Alphitobius diaperinus treated with cinnamon (Cinnamomum zeylanicum) essential oil on its free form, nanoemulsion (NE), and nanocapsule (NC), aswell as the effect of these treatments on the edaphic fauna using springtails of Folsomia candida (ISO) as a model. The tests with larvae and adults were performed using 1, 5, and 10% of the cinnamon essential oil, and 0.5, 1, and 5% of NE and NC containing 5% of cinnamon essential oil. To validate the test, three controlswere used: only oil diluent (Triton), blank nanoemulsion (without oil) and blank nanocapsule (without oil). Cinnamon essential oil at 5 and 10% caused mortality in larva and adult forms of A. diaperinus. The NE (1%) and NC (5%) causedmortality in both phases of A. diaperinus life cycle. After these promising findings,more studieswere conducted to verify the ecotoxicological effect of the cinnamon oil. For this, a Tropical Artificial Soil (TAS) was usedwith different doses of cinnamon oil, NE and NC, using springtails of F. candida. The use of cinnamon oil, even in very low concentrations (25 mg kg−1), on its original form significantly affected springtails survival and reproduction.However, the nanostructuring process seemed to minimize this toxic effectwithout affecting its insecticidal action. In summary, the pure oil and NE containing cinnamon oil showed effect against A. diaperinus, and may be considered an alternative to control this infestation.
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Isabella F.D. Pinto,Railmara P. Silva,Adriano de B. Chaves Filho,Lucas S. Dantas,Vanderson S. Bispo,Isaac A. Matos,Felipe A.M. Otsuka,Aline C. Santos,Humberto Reis Matos 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.7
Coconut water (CW) is a natural nutritious beverage, which contains several biologically active compounds that are traditionally used in the treatment of diarrhea and rehydration. Several works with CW have been related with antioxidant activity, which is very important in the diabetic state. To evaluate the hypoglycemic and nephroprotective activities of CW, alloxan-induced diabetic rats were pre- and post-treated by gavage with CW (3 mL/kg), caffeic acid (CA) (10 and 15 mg/kg), and acarbose (Acb) (714 μg/kg) during a period of 16 days. Body weight, blood glucose, glycated hemoglobin (HbA1c), and Amadori products in plasma and kidney homogenates were evaluated in all groups and used as parameters for the monitoring of the diabetic state. The results showed that rats of the CW+ diabetic group had maintenance in blood glucose compared with the control group (P < .05) in addition to a decrease of HbA1c levels and increase of body weight when compared with the diabetic group rats (P < .05). The animals of the CA and CA+ diabetic groups did not have significant variation of body weight (P < .05) during the experiment; however, they showed decrease in their HbA1c and urea levels in plasma as well as Amadori products in kidney homogenates when compared with the diabetic group (P < .05). Our results indicate that CW has multiple beneficial effects in diabetic rats for preventing hyperglycemia and oxidative stress caused by alloxan.
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