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Shalaby, Manal Ali,Nounou, Howaida Attia,Alanazi, Mohammad Saud,Alharby, Othman,Azzam, Nahla,Saeed, Hesham Mahmoud Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: It has been reported that COX-2 expression is associated with MMP-2 expression in thyroid and breast cancers, suggesting that MMPs are linked to COX-2-mediated carcinogenesis. Several polymorphisms within the MMP2 promoter region have been reported in cases with oncogenesis and tumor progression, especially in colorectal carcinogenesis. Materials and Methods: This research evaluated risk of association of the SNPs, including genes for COX-2 (AIG transition at +202) and MMP-2 (Crr transition at-1306), with colorectal cancer in 125 patients and 125 healthy controls. Results and Conclusions: Our data confirmed that MMP2 C-1306 T mutations were significantly more common in colon cancer patients than in our control Saudi population; p=O.0121. On the other hand in our study, there was no significant association between genotype distribution ofthe COX2 polymorphism and colorectal cancer; p=0.847. An elevated frequency ofthe mutated genotype in the control group as compared to the patients subjects indeed suggested that this polymorphism could decrease risk in the Saudi population. Our study confirmed that the polymorphisms that could affect the expressions of MMP-2 and COX-2 the colon cancer patients were significantly higher than that in the COX-2 negative group. The frequency of individuals with MMP2 polymorphisms in colon cancer patients was higher than individuals with combination of COX2 and MMP2 polymorphisms. Our study confirmed that individuals who carried the polymorphisms that could affect the expressions ofCOX2 are more susceptible to colon cancer. MMP2 regulatory polymorphisms could be considered as protective; further studies need to confirm the results with more samples and healthy subjects.
Saeed, Hesham Mahmoud,Alanazi, Mohammad Saud,Nounou, Howaida Attia,Shalaby, Manal Ali,Semlali, Abdelhabib,Azzam, Nahla,Aljebreen, Abdeulrahan,Alharby, Othman,Parine, Narasimha Reddy,Shaik, Jilani,Maha Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Background: The Saudi population has experienced a sharp increase in colorectal and gastric cancer incidences within the last few years. The relationship between gene polymorphisms of xenobiotic metabolizing enzymes and colorectal cancer (CRC) incidence has not previously investigated among the Saudi population. The aim of the present study was to investigate contributions of CYP1A1, CYP2E1, and GSTM1 gene polymorphisms. Materials and Methods: Blood samples were collected from CRC patients and healthy controls and genotypes were determined by polymerase chain reaction restriction fragment length polymorphism and sequencing. Results and Conclusions: $CYP2E1^*6$ was not significantly associated with CRC development (odd ratio=1.29; confidence interval 0.68-2.45). A remarkable and statistically significant association was observed among patients with $CYP1Awt/^*2A$ (odd ratio=3.65; 95% confidence interval 1.39-9.57). The $GSTM1^*0/^*0$ genotype was found in 2% of CRC patients under investigation. The levels of CYP1A1, CYP2E1 and GSTM1 mRNA gene expression were found to be 4, 4.2 and 4.8 fold, respectively, by quantitative real time PCR. The results of the present case-control study show that the studied Saudi population resembles Caucasians with respect to the considered polymorphisms. Investigation of genetic risk factors and susceptibility gene polymorphisms in our Saudi population should be helpful for better understanding of CRC etiology.
Diagnosing a Child with Autism using Artificial Intelligence
Alharbi, Abdulrahman,Alyami, Hadi,Alenzi, Saleh,Alharbi, Saud,bassfar, Zaid International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.6
Children are the foundation and future of this society and understanding their impressions and behaviors is very important and the child's behavioral problems are a burden on the family and society as well as have a bad impact on the development of the child, and the early diagnosis of these problems helps to solve or mitigate them, and in this research project we aim to understand and know the behaviors of children, through artificial intelligence algorithms that helped solve many complex problems in an automated system, By using this technique to read and analyze the behaviors and feelings of the child by reading the features of the child's face, the movement of the child's body, the method of the child's session and nervous emotions, and by analyzing these factors we can predict the feelings and behaviors of children from grief, tension, happiness and anger as well as determine whether this child has the autism spectrum or not. The scarcity of studies and the privacy of data and its scarcity on these behaviors and feelings limited researchers in the process of analysis and training to the model presented in a set of images, videos and audio recordings that can be connected, this model results in understanding the feelings of children and their behaviors and helps doctors and specialists to understand and know these behaviors and feelings.
Alharbi Reham A.,Aldardeer Namareq F.,Heaphy Emily L. G.,Alabbasi Ahmad H.,Albuqami Amjad M.,Hawa Hassan 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.2
Background Percent fluid overload greater than 5% is associated with increased mortality. The appropriate time for fluid deresuscitation depends on the patient's radiological and clinical findings. This study aimed to assess the applicability of percent fluid overload calculations for evaluating the need for fluid deresuscitation in critically ill patients. Methods This was a single-center, prospective, observational study of critically ill adult patients requiring intravenous fluid administration. The study's primary outcome was median percent fluid accumulation on the day of fluid deresuscitation or intensive care unit (ICU) discharge, whichever came first. Results A total of 388 patients was screened between August 1, 2021, and April 30, 2022. Of these, 100 with a mean age of 59.8±16.2 years were included for analysis. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 15.4±8.0. Sixty-one patients (61.0%) required fluid deresuscitation during their ICU stay, while 39 (39.0%) did not. Median percent fluid accumulation on the day of deresuscitation or ICU discharge was 4.5% (interquartile range [IQR], 1.7%–9.1%) and 5.2% (IQR, 2.9%–7.7%) in patients requiring deresuscitation and those who did not, respectively. Hospital mortality occurred in 25 (40.9%) of patients with deresuscitation and six (15.3%) patients who did not require it (P=0.007). Conclusions The percent fluid accumulation on the day of fluid deresuscitation or ICU discharge was not statistically different between patients who required fluid deresuscitation and those who did not. A larger sample size is needed to confirm these findings.
Clinical Efficacy and Possible Applications of Genomics in Lung Cancer
Alharbi, Khalid Khalaf Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
The heterogeneous nature of lung cancer has become increasingly apparent since introduction of molecular classification. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations. In light of the tsunami of new biomarkers and targeted agents, next generation sequencing testing strategies will be more appropriate in identifying the patients for each therapy and enabling personalized patients care. The challenge now is how best to interpret the results of these genomic tests, in the context of other clinical data, to optimize treatment choices. In genomic era of cancer treatment, the traditional one-size-fits-all paradigm is being replaced with more effective, personalized oncologic care. This review provides an overview of lung cancer genomics and personalized treatment.
E-Safety Awareness of Saudi Youths: A Comparative Study and Recommendations
Alharbi, Nawaf F,Soh, Ben,AlZain, Mohammed A,Alharbi, Mawaddah F International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.11
The use of the internet has become a basic need for many across the globe. The situation is very much the same for the youth in many countries like Saudi Arabia who have grown up surrounded and accessing the internet. This demographic, however, is at an increased risk of falling as victims to cybercrime because of a low level of technical awareness. This review looks at the level of technical awareness of internet use in 3 different countries which include the USA, South Africa, and New Zealand. The review will compare the situation in these nations with those in KSA. Based on the review and comparisons, recommendations are made for culturally and socially acceptable e-Safety awareness of Saudi youths.
Using a Genetic-Fuzzy Algorithm as a Computer Aided Breast Cancer Diagnostic Tool
Alharbi, Abir,Tchier, F,Rashidi, MM Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Computer-aided diagnosis of breast cancer is an important medical approach. In this research paper, we focus on combining two major methodologies, namely fuzzy base systems and the evolutionary genetic algorithms and on applying them to the Saudi Arabian breast cancer diagnosis database, to aid physicians in obtaining an early-computerized diagnosis and hence prevent the development of cancer through identification and removal or treatment of premalignant abnormalities; early detection can also improve survival and decrease mortality by detecting cancer at an early stage when treatment is more effective. Our hybrid algorithm, the genetic-fuzzy algorithm, has produced optimized systems that attain high classification performance, with simple and readily interpreted rules and with a good degree of confidence.
Sustainability Report Publication and Bank Share Price: Evidence from Saudi Arabia Stock Markets
ALHARBI, Mualla Ali,MGAMMAL, Mahfoudh Hussein,AL-MATARI, Ebrahim Mohammed Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
We examine the effects of the sustainability report (SURE) and investment decision on share price (SPRC). Explore whether the sustainability report changes the value-relevance of financial accounting variables indirectly. It is evident that the number of banks is only 12, which are all banks in Saudi Arabia, and we have included all of them in the final sample. Moreover, the same number of banks applied for the analysis concerning the accounting variables. This article utilizes a panel dataset from a sample of Saudis registered banks from the first quarter of 2014 to the last quarter of 2018. We utilize a balanced sample that contains all banks listed in Tadawul, 240 observations. Run GLM regression to tests the relationships. Findings exhibit that investors value the complementary disclosure of accounting information provided in SURE, and this disclosure produces a positive effect on SPRC. The SURE figure is robustly significant, suggesting that the market assigns a positive-significant correlation to the further information in the SURE. The indirect effects show that BPS×SURE is a positive-significant effect on SPRC, whereas EPS×SURE is positively-insignificant. The analysis shows that SURE's value relevance conforms through Saudis Banks, consistent with the hypothesis that diverse institutional perspectives probably influence the value-relevance of SURE.
Review Of Some Cryptographic Algorithms In Cloud Computing
Alharbi, Mawaddah Fouad,Aldosari, Fahd,Alharbi, Nawaf Fouad International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.9
Cloud computing is one of the most expanding technologies nowadays; it offers many benefits that make it more cost-effective and more reliable in the business. This paper highlights the various benefits of cloud computing and discusses different cryptography algorithms being used to secure communications in cloud computing environments. Moreover, this thesis aims to propose some improvements to enhance the security and safety of cloud computing technologies.