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안의환,정인환,오정환,이성태,김선남 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-
Early diagnosis is the key of proper management and reducing of complication in infectious condition of pelvic area. It is difficult to diagnose differentially between pyogenic arthritis of hip joint and osteomyelitis of pelvic bone around hip joint by bone scan that shows only 2 dimensional plane. But it is possible to differnetiate two lesions by SPECT that shows 3 dimensional plane. We report a case of osteomyelitis of ischium around the hip joint in a five year old girl who had severe painful swelling of left buttock, hip and thigh and fever for 2 days. Bone scan showed diffusely increased activity on left hip joint and also pelvic bone surrounding hip joint. But SPECT could visualize increased activity not on left hip joint but only on left ischium. So pyogenic arthritis of hip joint could be ruled out. The patient was cured without any complication by only administration of adequate antibiotics, under the diagnosis of acute osteomyelits of left ischium.
이준규,안재성,권순태,김환정,정제택 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2
This study was compared pre-operative MRI finding with operative finding on 36 cases with the failed back surgery syndrome (FBSS) retrospectively. The purpose of this study was to determine the accuracy of the MRI on the FBSS including early complications such as hematoma of infection. Of the 51 patients with FBSS, we analyzed pre-operative MRI finding compared with operative finding on 36 cases excluding nonunion, instability, metal failure and pseudoarthrosis who underwent an operation for the FBSS from December 1994 to June 1997. There were 25 men (69.4%) and 11 women (30.6%), aged from 16 to 68 years (average 43.6 years). These were divided into 5 sub-groups and calculated sensitivity, specificity and positive predictability. MRI accuracy in recurred disc was 84%, scar adhesion, recurred or developed stenosis, infection and hematoma 100% each and all, overall accuracy of the MRI 93%, respectively. Average interval of re-operation in FBSS WAS 4.3 years. In the 18 cases (50%), symptoms persist without pain-free interval after first operation. Early complications including hematoma and infection are easily detected with MRI. Especially if patient complains of severe leg pain or neurologic deficit, it is a good diagnostic procedure to check the MRI. The MRI is a useful method for evaluation of most cases of the FBSS, but it has limitations to evaluate recurred disc or scar adhesion only in T1, T2 weighted image. Therefore Gd-DTPA enhancement is necessary for the accurate diagnosis.
Erythromycin 내성 포도알균의 유도형 Macrolide-Lincosamide-Streptogramin B (MLS_(B)) 내성 표현형 빈도
김경희,박순호,박필환,안정열,서일혜 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Background: Inducible MLS_(B) (macrolide-lincosamide-streptogramin B) resistance in staphylococci is not detected by standard susceptibility test methods. Failure to identify inducible MLS_(B) resistance may lead to clinical failure during clindamycin therapy. We determined the prevalence of inducible MLS_(B) resistance in erythromycin-resistant staphylococcal isolates. Materials and Methods: We evaluated all 2,792 non-duplicate staphylococcal strains: 1,402 Staphylococcus aureus and 1,390 coagulase-negative staphylococci (CoNS) isolated from May 2008-June 2009 at one-unoversity hospital. Testing for inducible MLS_(B) was accomplished by the disk approximation test (D-test) in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Results: Of the 2,792 staphylococcal isolates, 892 S. aureus isolates and 740 CoNS isolates were resistant to erythromycin. Among the 892 erythromycin-resistant S. aureus isolates, the overall prevalence of inducible MLS_(B) was 21.3% (16.2% of MRSA and 76.3% of methicillin-susceptible S. aureus). Among the 740 erythromycinresistant CoNS isolates, the overall prevalence of inducible MLS_(B) was 16.5% (16.0% of methicillin-resistant CoNS and 18.7% of methicillin-susceptible CoNS). The D-test was positive in 88.8% of S. aureus and 28.4% of CoNS isolates, which were erythromycin-resistant and clindamycin-susceptible. Conclusions: There are some variations in the prevalence of inducible MLS_(B) resistance in clinical staphylococcal isolates. It is important that clinical laboratories report inducible MLS_(B) resistance for erythromycin-resistant and clindamycinsusceptible staphylococcal isolates.
Ahn, Ji Whan,Park, Hyun Seo,Kim, Jeong Hwan,Cheong, Sun Hee,Kim, Jeong Ah Trans Tech Publications, Ltd. 2006 Materials science forum Vol.510 No.-
<P>In this study, single phase aragonite PCC was synthesized by the solution process using Ca(OH)2 slurry and Na2CO3 solution as the main reactants. To begin with, the formation behavior of PCC polymorphs following changes in supersaturation was investigated, and the optimum synthetic condition of single-phase aragonite PCC was clarified after the role of NaOH in the reaction system was reviewed. In the results, it was considered that lower supersaturation was necessary to obtain a single phase aragonite; and, since the solubility of Ca(OH)2 was decreased with the addition of NaOH by a common ion effect, it is possible to perform a experiment at a lower Ca2+ concentration. In conclusion, in the case of the reaction of the 2.5M NaOH solution, single phase aragonite was obtained. Furthermore, NaOH solution was produced as a by-product in the solution process by reacting Ca(OH)2 slurry with Na2CO3. Thus, recycling of the NaOH solution was attempted in order to clear the environmental issue. It is difficult to recycle directly since the NaOH solution was diluted during the experiment. The optimum condition was investigated by control of experimental factors such as the concentration of Ca(OH)2, Na2CO3 and NaOH, and the reaction temperature, after which the NaOH solution was recycled without re-treatment. The formation characteristics of aragonite PCC, such as formation yield, particle morphology and aspect ratio, were investigated.</P>
Lee, Cheol Whan,Ahn, Jung-Min,Park, Duk-Woo,Kang, Soo-Jin,Lee, Seung-Whan,Kim, Young-Hak,Park, Seong-Wook,Han, Seungbong,Lee, Sang-Gon,Seong, In-Whan,Rha, Seung-Woon,Jeong, Myung-Ho,Lim, Do-Sun,Yoon, American Heart Association, Inc. 2014 CIRCULATION - Vol.129 No.3
<P><B>Background—</B></P><P>The risks and benefits of long-term dual antiplatelet therapy remain unclear.</P><P><B>Methods and Results—</B></P><P>This prospective, multicenter, open-label, randomized comparison trial was conducted in 24 clinical centers in Korea. In total, 5045 patients who received drug-eluting stents and were free of major adverse cardiovascular events and major bleeding for at least 12 months after stent placement were enrolled between July 2007 and July 2011. Patients were randomized to receive aspirin alone (n=2514) or clopidogrel plus aspirin (n=2531). The primary end point was a composite of death resulting from cardiac causes, myocardial infarction, or stroke 24 months after randomization. At 24 months, the primary end point occurred in 57 aspirin-alone group patients (2.4%) and 61 dual-therapy group patients (2.6%; hazard ratio, 0.94; 95% confidence interval, 0.66–1.35; <I>P</I>=0.75). The 2 groups did not differ significantly in terms of the individual risks of death resulting from any cause, myocardial infarction, stent thrombosis, or stroke. Major bleeding occurred in 24 (1.1%) and 34 (1.4%) of the aspirin-alone group and dual-therapy group patients, respectively (hazard ratio, 0.71; 95% confidence interval, 0.42–1.20; <I>P</I>=0.20).</P><P><B>Conclusions—</B></P><P>Among patients who were on 12-month dual antiplatelet therapy without complications, an additional 24 months of dual antiplatelet therapy versus aspirin alone did not reduce the risk of the composite end point of death from cardiac causes, myocardial infarction, or stroke.</P><P><B>Clinical Trial Registration—</B></P><P>URL: http://www.clinicaltrials.gov. Unique identifier: NCT01186146.</P>
Jeong, Jin-Ok,Kim, Jeong-Hee,Ahn, Kye-Taek,Park, Hyung Seo,Jang, Won Il,Park, Jae-Hyeong,Lee, Jae-Hwan,Choi, Si Wan,Kim, Jin Man,Seong, In-Whan The Korean Society of Cardiology 2010 Korean Circulation Journal Vol.40 No.11
<P><B>Background and Objectives</B></P><P>Vascular smooth muscle cell (VSMC) proliferation is responsible for the restenosis of previously inserted coronary stents. Angiotensin II (Ang II) is known to regulate VSMC proliferation. LKB1, a serine/threonine kinase, interacts with the p53 pathway and acts as a tumor suppressor.</P><P><B>Materials and Methods</B></P><P>We assessed the association of Ang II and the expression of LKB1 in primary cultured murine VSMCs and neointima of the Sprague Dawley rat carotid artery injury model. We created carotid balloon injuries and harvested the injured carotid arteries 14 days after the procedure.</P><P><B>Results</B></P><P>Ang II increased LKB1 expression in a time-dependent manner and peaked at an Ang II concentration of 10<SUP>-7</SUP> mole/L in VSMCs. In the animal experiment, neointima was markedly increased after balloon injury compared to the control group. Immunohistochemical studies showed that LKB1 expression increased according to neointima thickness. Ang II augmented LKB1 expression after the injury. Western blot analysis of LKB1 with carotid artery lysate revealed the same pattern as LKB1 immunohistochemistry. Increased LKB1 expression started at 5 days after the balloon injury, and peaked at 14 days after the injury. Although LKB1 expression was increased after the injury, LKB1 kinase activity was not increased. Ang II or balloon-injury increased the expression of LKB1 although the LKB1 activity was reduced.</P><P><B>Conclusion</B></P><P>Ang II increased LKB1 expression in VSMCs and neointima. These findings were not kinase dependant.</P>
Usefulness of K-Point Injection for the Nonspecific Neck Pain in So-Called K-Point Syndrome
Jeong Jae Moon,Myun Whan Ahn,Hyo Sae Ahn,Sung Jun Lee,Dong Yeol Lee 대한정형외과학회 2016 Clinics in Orthopedic Surgery Vol.8 No.4
Background: Shoichi Kokubun introduced his successful experience with local anesthetic injection at the occipital insertion of the sternocleidomastoid muscle in K-point syndrome. The purpose of this study was to evaluate the short-term and long-term effectiveness of K-point injection and investigate factors affecting treatment results. Methods: K-point injection was performed in 58 patients with K-point syndrome at Yeungnam University Medical Center. The syndrome was associated with cervical whiplash injury in 10 patients and was of nonspecific origin in the rest. One milliliter of 2% lidocaine mixed with 1 milliliter of dexamethasone was injected in 50 patients and 2 milliliters of 1% lidocaine alone in the rest. Initially, the severity of local tenderness at the K-point and other tender points was examined and the degree of immediate pain relief effect was assessed within 1 hour after injection. Early effect within 1 month after the injection and current effect were evaluated in 27 patients using a modified Kim's questionnaire with regard to the duration of improvement, degree of improvement in pain and daily living activities, and satisfaction. Results: Of the total 58 patients, 44 (75.8%) apparently had immediate pain relief after K-point injection. The only factor associated with successful immediate pain relief was the whiplash injury associated with traffic accident (TA). The early pain control effect was associated with the immediate effect. The current effect was associated with the early effect alone. Satisfaction with the K-point injection was related to early successful pain relief. Conclusions: K-point injection would be useful for early pain relief in nonspecific neck pain syndrome so called K-point syndrome, but not for current pain relief. Especially, it was very effective for early pain control in the whiplash injury associated with TA.
Brachial-ankle PWV for predicting clinical outcomes in patients with acute stroke
Ahn, Kye Taek,Jeong, Jin-Ok,Jin, Seon-Ah,Kim, Mijoo,Oh, Jin Kyung,Choi, Ung-lim,Seong, Seok-Woo,Kim, Jun Hyung,Choi, Si Wan,Jeong, Hye Seon,Song, Hee-Jung,Kim, Jei,Seong, In-Whan Informa UK (Taylor Francis) 2017 Blood pressure Vol.26 No.4