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RISS 인기검색어
- 검색키워드
- 저자 : Ahmed A. Tantawy (검색결과 2 건)
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Anticancer efect of some fruits peels aqueous extracts
Deyala M. Naguib,Ahmed A. Tantawy 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
Fruits peels are considered one of the most waste products of food industry. In this paper we attempt to get useful of these peels with low cost methods. We prepared aqueous extract of peels of apple, banana, guava, kiwi, lemon, mango, orange, papaya, pomegranate and watermelon. The anticancer activity of the extracts against diferent cell lines was examined using the cell viability test using MTT assay. The aqueous extract of peels of banana, pomegranate, orange and lemon showed the highest anticancer activity against the tested cell lines [pancreatic (AsPC1), breast (MCF7) human cancer cell lines colon cancer cell line (HCT116), larynx cancer cell line (HEP2) and liver cancer cell line (HEPG2)], as they have high antioxidant capacity. Beside that these peels extract contain high content of very important pharmaceutical compounds such as alkaloid, tannin, saponin, steroid, glycosidic cyanide, phytate, phenolic and favonoid. Kiwi and watermelon peels extract did not show any anticancer activity against the diferent tested cell lines. Also they have the lowest antioxidant and pharmaceutical compounds content.
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Blocking Toll-like receptor 9 attenuates bleomycin-induced pulmonary injury
Badr Alzahrani,Mohamed M. S. Gaballa,Ahmed A. Tantawy,Maha A. Moussa,Salma A. Shoulah,Said M. Elshafae 대한병리학회 2022 Journal of Pathology and Translational Medicine Vol.56 No.2
Background: Acute respiratory distress syndrome (ARDS) is one of the most common complications in coronavirus disease 2019 patients suffering from acute lung injury (ALI). In ARDS, marked distortion of pulmonary architecture has been reported. The pulmonary lesions in ARDS include hemodynamic derangements (such as alveolar edema and hemorrhage), vascular and bronchiolar damage, interstitial inflammatory cellular aggregations, and eventually fibrosis. Bleomycin induces ARDS-representative pulmonary damage in mice and rats; therefore, we used bleomycin model mice in our study. Recently, Toll-like receptor 9 (TLR9) was implicated in the development of ARDS and ALI.Methods: In this study, we evaluated the efficiency of a TLR9 blocker (ODN2088) on bleomycin-induced pulmonary damage. We measured the apoptosis rate, inflammatory reaction, and fibroplasia in bleomycin- and bleomycin + ODN2088-treated mice.Results: Our results showed a significant amelioration in bleomycin-induced damage to pulmonary architecture following ODN2088 treatment. A marked decrease in pulmonary epithelial and endothelial apoptosis rate as measured by cleaved caspase-3 expression, inflammatory reaction as indicated by tumor necrosis factor α expression, and pulmonary fibrosis as demonstrated by Van Gieson staining and α-smooth muscle actin immunohistochemistry were observed following ODN2088 treatment.Conclusions: All these findings indicate that blocking downstream TLR9 signaling could be beneficial in prevention or mitigation of ARDS through hemodynamic derangements, inflammation, apoptosis, and fibrosis.
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