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Zahra Sharifi,Mahmoud Pakshir,Abbas Amini,Rahim Rafiei 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.74 No.-
Nitrogen, sulfur and phosphorous atoms were chemically introduced to graphene oxide nanostructure(NSP-GO) to construct a corrosion inhibitor for mild steel in a 3.5 wt% NaCl solution. The anticorrosiveeffects of NSP-GO on two synthesized water-soluble polymeric compounds, melamine formaldehyde(MF) and urea formaldehyde (UF), were investigated in the saline environment. With NSP-GO, theinhibition efficiency of 93% (for UF) and 95% (MF) reached to ~100% for both composites at 500 ppmconcentration. The heteroatoms of decorated GO sheets act like anchors to pull GO sheets towards themetal surface and make MF and UF polymersfilms as full protectors.
Development of a $^{68}Ga$-Fluorinated Porphyrin Complex as a Possible PET Imaging Agent
Fazaeli, Yousef,Jalilian, Amir R.,Amini, Mostafa M.,Ardaneh, Khosro,Rahiminejad, Ali,Bolourinovin, Fatemeh,Moradkhani, Sedigheh,Majdabadi, Abbas The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.1
Aim Due to the interesting pharmacologic properties of porphyrins, the idea of developing a possible tumor imaging agent using PET by incorporating $^{68}Ga$ into a suitable porphyrin ligand was investigated. Methods $^{68}Ga$-labeled 5,10,15,20-tetrakis(pentafluoro-13 phenyl) porphyrin ($^{68}Ga$-TFPP) was prepared using freshly eluted $[^{68}Ga]GaCl_3$ obtained from a 68Ge/68Ga generator developed in-house and 5,10,15,20-tetrakis(pentafluorophenyl) porphyrin (H2TFPP) for 60 min at $100^{\circ}C$. Results The complex was prepared with high radiochemical purity (>99% ITLC, >99% HPLC, specific activity: 13-14 GBq/mmol). Stability of the complex was checked in the final formulation and in human serum for 5 h. The partition coefficient was calculated for the compound (log P = 0.62). The biodistribution of the labeled compound in vital organs of Swiss mice bearing fibrosarcoma tumors was studied using scarification studies and SPECT imaging up to 1 h. The complex was mostly washed out from the circulation through kidneys and liver. The tumor-to-muscle ratio 1 h post injection was 5.13. Conclusion The radiolabeled porphyrin complex demonstrated potential for further imaging studies in other tumor models.
Hasti Sarkarzadeh,Ramin Miri,Omidreza Firuzi,Mohsen Amini,Nima Razzaghi-Asl,Najmeh Edraki,Abbas Shafiee 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.4
A series of new imidazole substituted indeno[1,2-b]quinoline-9,11-dione derivatives were synthesizedand evaluated for their antiproliferative effects on HeLa,LS180, MCF-7 and Jurkat human cancer cell lines. Antiproliferativeeffects were evaluated using MTT assay. Prepared compounds exhibited weak to good antiproliferativeactivity in evaluated cell lines. Prepared compoundswere more potent in Jurkat cell line when compared toLS180, HeLa and MCF-7 cell lines. Compounds 29(IC16 = 0.7 lM) and 31 (IC16 = 1.7 lM) and 33 (IC16 =1.7 lM) were found to be the most potent molecules onJurkat cell lines. Moreover; it was found that some of thetested compounds bearing imidazole-2-yl moiety on theC11-position of dihydropyridine ring exhibited superiorantiproliferative activity in comparison to cis-platin especiallyin Jurkat cell line (compounds 29, 31, and 33). Itseemed that the introduction of electron-withdrawinggroups on the imidazole ring enhanced the antiproliferativepotential of these compounds (compounds 27, 29 and 31). The results of this study proposed that some of the imidazolesubstituted indeno[1,2-b]quinoline-9,11-dione compoundsmay act as efficient anticancer agents in vitro,emphasizing their potential role as a source for rationaldesign of potent antiproliferative agents.
Firoozpour, Loghman,Emami, Saeed,Mansouri, Shahla,Ebrahimabadi, Abdolrasoul H.,Asadipour, Ali,Amini, Mohsen,Saeid-Adeli, Nosratollah,Shafiee, Abbas,Foroumadi, Alireza 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.2
A series of N-[5-(chlorobenzylthio)-1,3,4-thiadiazol-2-yl] piperazinyl quinolones derivatives (4a-I) have been synthesized by reaction of piperazinyl quinolones with 5-chloro-2-(chlorobenzylthio)-1,3,4-thiadiazoles. Their structures were confirmed by elemental analysis, IR and NMR spectra. The antibacterial activities of 4a-I against a variety of Gram-positive and Gram-negative bacteria were determined. Several compounds showed a good antibacterial activity against Gram-positive bacteria among which, compound 4e with a 2-chlorobenzylthio moiety in ciprofloxacin derivative, exhibited high activities against Staphylococcus aureus and Staphylococcus epidermidis (MIC=0.06 ${\mu}$g/mL). The structure-activity relationship (SAR) study revealed that the position of chlorine atom on benzyl moiety would dramatically affect the antibacterial activities of the synthesized compounds.
Alireza Foroumadi,Loghman Firoozpour,Saeed Emami,Shahla Mansouri,Abdolrasoul H. Ebrahimabadi,Ali Asadipour,Mohsen Amini,Nosratollah Saeid-Adeli,Abbas Shafiee 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.2
A series of N-[5-(chlorobenzylthio)-1,3,4-thiadiazol-2-yl] piperazinyl quinolone derivatives (4a-l) have been synthesized by reaction of piperazinyl quinolones with 5-chloro-2-(chlorobenzylthio)- 1,3,4-thiadiazoles. Their structures were confirmed by elemental analysis, IR and NMR spectra. The antibacterial activities of 4a-l against a variety of Gram-positive and Gram-negative bacteria were determined. Several compounds showed a good antibacterial activity against Gram-positive bacteria among which, compound 4e with a 2-chlorobenzylthio moiety in ciprofloxacin derivative, exhibited high activities against Staphylococcus aureus and Staphylococcus epidermidis (MIC=0.06 µg/mL). The structure-activity relationship (SAR) study revealed that the position of chlorine atom on benzyl moiety would dramatically affect the antibacterial activities of the synthesized compounds.