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Nnanake-Abasi O. Offiong,Godwin J. Udo,Edu J. Inam,Akanimo N. Ekanem,Joachim J. Awaka-ama,Emaime J. Uwanta,Jun Dong 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.2
In this study, we screened the performance of aqueous extracts of Talinum triangulare (AET) and soap solution prepared from Hura crepitans seed oil saponified by aqueous solution of ashed plantain peels (HCS) for removal of naphthalene and phenanthrene from soil. The distribution of trace metals in the soil before and after soil washing was also investigated. The results revealed maximum removal efficiencies after 25 min washing time of 96.25, 96.14, and 25.70% naphthalene, for Tween 80, AET and HCS, respectively. While for phenanthrene, the recorded maximum removal efficiencies after 25 min washing time were: 91.80, 26.00, and 94.0 for Tween 80, AET and HCS, respectively. Based on results from other experiments, AET generally showed slightly lower removal efficiencies compared to the commercial Tween 80 surfactant. Also, the results revealed that the three remediants affected the distribution of trace metals (Cd, Pb, and Zn) in the soil after surfactant washing. Based on the amount of trace metals extracted, the performance of the three remediants are as follows: AET > Tween 80 > HCS. The performance of AET has been attributed to the presence of multiple heteroatomic moieties for trace metals adsorption and moderation of the acidic conditions of the soil.
Anti-Proliferative Properties of Cornus mass Fruit in Different Human Cancer Cells
Yousefi, Bahman,Abasi, Mozhgan,Abbasi, Mehran Mesgari,Jahanban-Esfahlan, Rana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: There is a long standing interest in natural compounds especially those with a high polyphenolic content and high scavenging activity for hazardous free radicals. Cornus mas (CM) fruit is well known for its antioxidant activities; however, its toxicity against human cancers needs to be addressed. Here, we investigated selective anticancer effects of CM on different human cancer cells. Materials and Methods: A hydro-alcoholic extract of CM (HECM) was prepared and total phenolic content (TPC) and total flavonoid content (TFC) were determined by colorimetric assays. Antioxidant activity was assessed with respectto DPPH radical scavenging. MTT assays were used to evaluate the cytotoxicity of different doses of CM (0, 5, 20, 100, 250, 500, $1000{\mu}g/ml$) towards A549 (lung non small cell cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer) and PC-3 (prostate adenocarcinoma) cells. Results: Significant (P<0.05) or very significant (P<0.001) differences were observed in comparison to negative controls at all tested doses ($5-1000{\mu}g/ml$). In all cancer cells, HECM reduced the cell viability to values below 26%, even at the lowest doses. In all cases, $IC_{50}$ was obtained at doses below $5{\mu}g/ml$. The mean growth inhibition was 81.8%, 81.9%, 81.6% and 79.3% in SKOV3, MCF-7, PC-3 and A549 cells, respectively. Conclusions: Altogether, to our best knowledge, this is a first study that evaluated toxicity of a HECM with high antioxidant activity in different human cancer cells in vitro. Our results indicated that a hydro-alcoholic extract of CM possesses high potency to inhibit proliferation of different tumor cells in a dose independent manner, suggesting that an optimal biological dose is more important and relevant than a maximally tolerated one.
Modaeinama, Sina,Abasi, Mozhgan,Abbasi, Mehran Mesgari,Jahanban-Esfahlan, Rana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: Medicinal plants, especially examples rich in polyphenolic compounds, have been suggested to be chemopreventive on account of antioxidative properties. Punica granatum (PG) (pomegranate) is a well known fruit in this context, but its cytotoxicity in cancer cells has not been extensively studied. Here, we investigated the antiproliferative properties of a peel extract of PG from Iran in different human cancer cells. Materials and Methods: A methanolic extract of pomegranate peel (PPE) was prepared. Total phenolic content(TPC) and total flavonoid conetnt (TFC) were determined by colorimetric assays. Antioxidant activity was determined by DPPH radical scavenging activity. The cytotoxicity of different doses of PPE (0, 5, 20, 100, 250, 500, $1000{\mu}g/ml$) was evaluated by MTT assays with A549 (lung non small cell cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer), and PC-3 (prostate adenocarcinoma) cells. Results: Significant (P<0.01) or very significant (P<0.0001) differences were observed in comparison with negative controls at all tested doses (5-$1000{\mu}g/ml$). In all studied cancer cells, PPE reduced the cell viability to values below 40%, even at the lowest doses. In all cases, IC50 was determined at doses below $5{\mu}g/ml$. In this regard, MCF-7 breast adenocarcinoma cells were the most responsive cells to antiprolifreative effects of PPE with a maximum mean growth inhibition of 81.0% vs. 69.4%, 79.3% and 77.5% in SKOV3, PC-3 and A549 cells, respectively. Conclusions: Low doses of PPE exert potent anti-proliferative effects in different human cancer cells and it seems that MCF-7 breast adenocarcinoma cells are the most cells and SKOV3 ovarian cancer cells the least responsive in this regard. However, the mechanisms of action need to be addressed.
Zakavi, Saeed,Abasi, Azam,Pourali, Ali Reza,Talebzadeh, Sadegh Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.1
Room temperature oxidation of organic sulfides with polyvinylpyrrolidone-supported hydrogen peroxide (PVP-$H_2O_2$) in the presence of Mn(III) complexes of meso-tetraphenylporphyrin, Mn(TPP)X (X = OCN, SCN, OAc, Cl) and imidazole (ImH) leads to the highly chemoselective (ca. 90%) oxidation of sulfides to the corresponding sulfoxide. The efficiency of reaction has been shown to be influenced by different reaction parameters such as the nature of counterion (X) and solvent as well as the molar ratio of reactants. Using Mn(TPP)OCN and ImH in 1:15 molar ratio and acetone as the solvent leads to the efficient oxidation of different sulfides.
Quick and Accurate Computation of Voltage Stability Margin
Karbalaei, Farid,Abasi, Shahriar The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.1
It is well known that the behavior of PV curves is similar to a quadratic function. This is used in some papers to approximate PV curves and calculate the maximum-loading point by minimum number of power flow runs. This paper also based on quadratic approximation of the PV curves is aimed at completing previous works so that the computational efforts are reduced and the accuracy is maintained. To do this, an iterative method based on a quadratic function with two constant coefficients, instead of the three ones, is used. This simplifies the calculation of the quadratic function. In each iteration, to prevent the calculations from diverging, the equations are solved on the assumption that voltage magnitude at a selected load bus is known and the loading factor is unknown instead. The voltage magnitude except in the first iteration is selected equal to the one at the nose point of the latest approximated PV curve. A method is presented to put the mentioned voltage in the first iteration as close as possible to the collapse point voltage. This reduces the number of iterations needed to determine the maximum-loading point. This method is tested on four IEEE test systems.
Saeed Zakavi,Azam Abasi,Ali Reza Pourali,Sadegh Talebzadeh 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.1
Room temperature oxidation of organic sulfides with polyvinylpyrrolidone-supported hydrogen peroxide (PVP-H2O2) in the presence of Mn(III) complexes of meso-tetraphenylporphyrin, Mn(TPP)X (X = OCN, SCN,OAc, Cl) and imidazole (ImH) leads to the highly chemoselective (ca. 90%) oxidation of sulfides to the corresponding sulfoxide. The efficiency of reaction has been shown to be influenced by different reaction parameters such as the nature of counterion (X) and solvent as well as the molar ratio of reactants. Using Mn(TPP)OCN and ImH in 1:15 molar ratio and acetone as the solvent leads to the efficient oxidation of different sulfides.
Anti-Proliferative Effects of Hesa-A on Human Cancer Cells with Different Metastatic Potential
Jahanban-Esfahlan, Rana,Abasi, Mozhgan,Sani, Hakimeh Moghaddas,Abbasi, Mehran Mesgari,Akbarzadeh, Abolfazl Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: During the past few years, Hesa-A, a herbal-marine mixture, has been used to treat cancer as an alternative medicine in Iran. Based on a series of studies, it is speculated that Hesa-A possesses special cytotoxic effects on invasive tumors. To test this hypothesis, we investigated the selective anticancer effects of Hesa-A on several cancer cell lines with different metastatic potential. Materials and Methods: Hesa-A was prepared in normal saline as a stock solution of 10 mg/ml and further diluted to final concentrations of $100{\mu}/ml$, $200{\mu}g/ml$, $300{\mu}g/ml$ and $400{\mu}g/ml$. MTT-based cytotoxicity assays were performed with A549 (lung non small cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer), and PC-3 (prostate adenocarcinoma) cells. Results: All treated cancer cells showed significant (P<0.01) or very significant (P<0.0001) differences in comparison to negative control at almost all of the tested doses ($100-400{\mu}g/ml$). At the lower dose ($100{\mu}g/ml$), Hesa-A reduced cell viability to 66%, 45.3%, 35.5%, 33.2% in SKOV3, A549, PC-3 and MCF-7 cells, respectively. Moreover, at the highest dose ($400{\mu}g/ml$), Hesa-A resulted in 88.5%, 86.6%, 84.9% and 79.3% growth inhibition in A549, MCF-7, PC-3 and SKOV3 cells, respectively. Conclusions: Hesa-A exert potent cytotoxic effects on different human cancer cells, especially those with a high metastatic potential.
Quick and Accurate Computation of Voltage Stability Margin
Farid Karbalaei,Shahriar Abasi 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.1
It is well known that the behavior of PV curves is similar to a quadratic function. This is used in some papers to approximate PV curves and calculate the maximum-loading point by minimum number of power flow runs. This paper also based on quadratic approximation of the PV curves is aimed at completing previous works so that the computational efforts are reduced and the accuracy is maintained. To do this, an iterative method based on a quadratic function with two constant coefficients, instead of the three ones, is used. This simplifies the calculation of the quadratic function. In each iteration, to prevent the calculations from diverging, the equations are solved on the assumption that voltage magnitude at a selected load bus is known and the loading factor is unknown instead. The voltage magnitude except in the first iteration is selected equal to the one at the nose point of the latest approximated PV curve. A method is presented to put the mentioned voltage in the first iteration as close as possible to the collapse point voltage. This reduces the number of iterations needed to determine the maximum-loading point. This method is tested on four IEEE test systems.