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RISS 인기검색어
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- 저자 : 허대석(D . S . Heo) (검색결과 2 건)
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박병주,이무송,안윤옥,허대석,김동현,김헌,유하성,박태수,Park, B.J.,Lee, M.S.,Ahn, Y.O.,Heo, D.S.,Kim, D.H.,Kim, H.,Yew, H.S.,Park, T.S. 대한예방의학회 1996 Journal of Preventive Medicine and Public Health Vol.29 No.3
Nationwide incidence survey was conducted to estimate the annual incidence rates of colorectal cancer among Koreans between Jan 1, 1988 and Dec 31, 1989. The population of the incidence survey was the beneficiaries of Korea Medical Insurance Corporation (KMIC), which were about 4,500,000 persons. The medical records of patients with diagnosis of either ICD-9 153(colon cancer), 154(rectal caner), 197(secondary malignant neoplasm of digestive and respiratory system), or 211(benign neoplasm of digestive system) were abstracted for the period with the standard format. The diagnosis was confirmed by one oncologist through the review of these abstracts. The numerator of the rate was finally defined as the incident colorectal cancer cases diagnosed between July 1, 1988 and June 30, 1989. The crude annual incidence of colorectal cancer for men was 13.1 per 100,000 and 10.6 for women, which was still low when compared with those of Japan and China during the same period. Age-adjusted sex ratio was 1.2 for right-sided colon cancer and 1.9 for left-sided colon cancer. The excess of right colon cancer among postmenopausal women was remarkable, so further analytical approach would be needed to investigate which factors are related with this phenomenon.
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이종태(J . T . Lee),이근석(K . S . Lee),김인호(I . H . Kim),방영주(Y . J . Bang),박선양(S . Y . Park),김병국(B . K . Kim),김노경(N . N . Kim),허대석(D . S . Heo) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: Malignant histiocytosis is a rare, rapidly fatal disorder, characterized by systemic proliferation of abnormal histiocytes. Most patients present with fever, organomegaly, and pancytopenia, and die within a few months. Although malignant histiocytosis represents diagnostically an important histiocytic disorder, its pathogenesis, natural history, response to therapy are not well known. In Korea, there are few reports on malignant histiocytosis. The purpose of this investigation is to assess the clinical spectrum natural history, laboratory findings, histopathologic findings response to therapy of malignant histijiocytos is diagnosed at Seoul national university hospital. Methods: The clinical records and histologic materials from 29 cases of malignant histiocytosis diagnosed at Seoul national university hospital between 1985 and 1994 have been reviewed. The criteria for the histopathologic diagnosis of malignant histiocytosis were the presence of large, abnormal malignant histiocytes with frequent mistosis to be distinguished from reactive histiocytic proliferation. All histologic materials were fixed in formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin. Bone marrow aspirates were stained with Jener-Giemsa. of 29 patients, 20 patients were treated with combination chemotherapy; CHOP in 8 patients, COPBLAM in 3 patients, BVP in 7 patients, C-MOPP in 1 patient, Pdplusvincristine in 1 patient. Results: The median age was 32 years, with a 2.2:1 male to female prepondance. Major physical findings included temperature elevation (93%), hepatomegaly (90%), splenomegaly (86%), jaundice (5%). Common laboratory findings were anemia (86%), thrombocytopenia (90%), splenomegaly (86%), jaundice (45%). Common laboratory findings were anemia (86%), thrombocytopenia (90%), leukopenia (72%), hypocalcemia (97%), abnormal liver function test (100%). Histologic features observed in bone marrow were increased histiocytes, atypical immature histiocytic infiltration with hemophagocytosis. Histologic features observed in lymph node were destruction of normal structure with infiltration and proliferation of immature histiocytes. Prominent features observed in liver were sinusoidal histiocytic infiltration. The response to treatment was encouraging. One patient achieved a completed remission (5%), 5 patients achieved a partial remission (25%), and overall response rates were 30%. Conclusion: The distinctive clinical and histologic findings warrant recognition and separation of malignant histiocytosis from other histiocytic and hematopoietic disorders and long-term survival is possible in some patients if treated early and aggressively with combination chemotherapy.
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