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폐결핵환자에서 기관지폐포세척액 및 말초혈액의 임파구 아형에 관한 연구
한성구(S . K . Han),조상헌(S . H . Cho),김준우(J . W . Kim),김영환(Y . W . Kim),심영수(Y . S . Shim),김건열(K . Y . Kim),한용철(Y . C . Han) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A It is known that the helper T-cell subset of T-lymphocyte is decreased in the peripheral blood of tuberculosis patients. To explain this phenomenon, the compartmentalization theroy, suppressor monocyte and clonal expansion theory and others were proposed. To elucidate these phenomenon, we examined the changes of lymphocyte subsets in bronchoalveolar lavage fluid and peripheral blood of pulmonary tuberculosis patients by double bridge technique of alkaline phosphatase-anti-alkaline phosphatase (APAAP) using monoclonal antibodies, and obtained the following results. 1) Total cell count of bronchoalveolar lavage fluid in pulmonary tuberculosis patients was 28±14.5×106 and showed significantly increased value compared with control group of 16.96±10.75×106(P<0.01). The T-lymphocyte percentage ratio to total cell count was 30.11±17.21% in pulmonary tuberculosis patients and it showed significantly increased ratio compared with 6.85±2.11% of control group (p<0.05). 2) Helper T-cell/suppressor T-cell ratio in the peripheral blood of pulmonary tuberculosis patients was 1.32±0.2 and showed significantly lower value compared with 1.58±0.19 of control group (p<0.05). Total T-lymphocyte and helper T-cells were also decreased but not in the magnitude of statistical significance. Suppressor T-cell showed no difference between pulmonary tuberculosis patients and control group. 3) Total T-lymphocyte (mean 64.84%) and helper T-cells (mean 41.9%) in bronchoalveolar lavage fluid of pulmonary tuberculosis patients were significantly increased than the control group of 53.42% and 32.28%. Helper T-cell/suppressor T-cell ratio was 1.9±0.58 in pulmonary tuberculosis patients and 1.5±0.16 in control group with no significant difference (p>0.05). There was no difference of suppressor T-cells of bronchoalveolar lavage fluid between the two comparing groups. 4) In pulmonary tuberculosis patients, total T- lymphocytes (mean 64.84%) and helper T-cells (mean 41.92%) in the bronchoalveolar lavage fluid were significantly increased than in the peripheral blood (44.92% and 27.00%). And helper T-cell/suppressor T-cell ratio (mean 1.92) was also increased in bronchoalveolar lavage fluid than in the peripheral blood (mean 1.32), but suppressor T-cells showed no difference between the bronchoalveolar lavage fluid and peripheral blood.
특발성 폐섬유화증 환자에서 기관지폐포세척액 소견과 생리-방사선-조직학적 진행도와의 상관관계 및 스테로이드 치료에 대한 예후인자와 구성세포 변화에 관한 연구
조상헌 ( S. H. Cho ),이상도 ( S. D. Lee ),권오정 ( O. J. Kwon ),이춘택 ( C. T. Lee ),정희순 ( H. S. Chung ),한성구 ( S. K. Han ),심영수 ( Y. S. Shim ),김건열 ( K. Y. Kim ),한용철 ( Y. C. Han ),함의근 ( E. K. Ham ) 대한결핵 및 호흡기학회 1989 Tuberculosis and Respiratory Diseases Vol.36 No.4
증례 : Crouzon 씨병 ( 두개안면골화부전증 , Dysostosis craniofacialis ) 의 1 예
신현정 ( H. C. Shin ),이창홍 ( C. H. Lee ),김대하 ( D. H. Kim ),한용철 ( Y. C. Han ),강석영 ( S. Y. Kang ) 대한내과학회 1970 대한내과학회지 Vol.13 No.12
Premature synostosis of cranial sutures is called craniostenosis. The etiology of premature closure of the sutures is not known although many theories were described. The most generally accepted is that premature fusion is due to a defect in the portion of