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증례 : Crouzon 씨병 ( 두개안면골화부전증 , Dysostosis craniofacialis ) 의 1 예
신현정 ( H. C. Shin ),이창홍 ( C. H. Lee ),김대하 ( D. H. Kim ),한용철 ( Y. C. Han ),강석영 ( S. Y. Kang ) 대한내과학회 1970 대한내과학회지 Vol.13 No.12
Premature synostosis of cranial sutures is called craniostenosis. The etiology of premature closure of the sutures is not known although many theories were described. The most generally accepted is that premature fusion is due to a defect in the portion of
이창홍 ( Chang Hong Lee ),이중근 ( C. K. Lee ),장재헌 ( J. H. Chang ) 대한내과학회 1971 대한내과학회지 Vol.14 No.2
Authors report a case of uncommon connective tissue disorder, polymyositis. Polymyositis, more accurate terminology of dermatomyositis without skin manifestation, is characterized by progressive muscular weakness with various rheumatoid manifestation, freq
박승철,이미안,최혜란,최한상,김성윤,정선근,박찬현,김태화,석성억,이창홍 대한감염학회 1984 감염 Vol.16 No.1
Cefotaxime은 반합성 Cephalosporin 제제로서 광범위항생제이며 β-lactamase에 안정성을 갖고 있으며 S. typhi에 대해서는 최저저지농도가 0.04㎍/dl로서 매우 유요한 것으로 나타나 있다. Mekendrik은 2예의 장티푸스환자에서 Cefotaxime 4.0gm/day 치료로 임상적인 효과를 못보았다고 한다. 그 이유는 Cefotaxime이 포유동물의 세포내로 침투하기 어려운 때문이라고 하였으며 또다른 임상연구에서는 Cefotaxime 투여 24시간후 혈액배양에서 S. typhi가 자란다고 한다. 본 연구에서는 45명의 많은 환자에서 Cefotaxime을 투여한 결과 비교적 양호한 치료효과를 얻었다. Table2에서 보는 바와 같이 45명중 31명이 7일이내에 치료 효과를 보였다. 평균 치료기간이 6.9일로서 Chloram-phenicol 투여시의 5.4일 보다는 길으나 임상적으로는 치료제로서 사용할만한 약제로 볼 수 있다. Santiago 에서의 연구결과는 Chloramphenicol 5.1일, Ampicillin은 6.7일이었으며 Co-trimoxazole은 7일이었다. 31명의 환자에서 Cefotaxime 2.0 gm/day의 용량으로는 해열이 되지않으므로 1 일 4.0 gm으로 중량하여 평균 3.2일만에 해열이 되었다. 그러나 초기치료부터 1일 4.0 gm 으로 시작한 자료가 없으므로 용량간에 효과를 비교할만한 근거는 없다. 3예의 재발과 5예의 단기보균자수는 Amoxycillin 치료시와 유사하다. 이들은 Co-trinoxazole로 치료하였다. 3예의 장출혈환자는 Cefortaxime의 부작용은 아니며 장티푸스환자에서 통상적으로 볼 수 있는 합병증이라고 사료된다. Cefotaxime 투여시 약간의 피부발진 이외의 부작용을 발견할 수 없었다. Cefotaxime은 가격이 비싸고 경구적 투여라는 단점이 있으나 골수장애를 일으킬 수 있는 Chloramphenicol에 대신해서 장티푸스치료에 사용할 수 있는 약제다.
腸티브스에 對한 Bactrim^(�) 治療의 臨床的 觀察
金大河,李重根,李昌弘,李宰燮,魯炳鎬 최신의학사 1971 最新醫學 Vol.14 No.1
The Present study was carried out in order to evaluate the therapeutic effect of Bactrim in 23 selected patients with typhoid fever who were admitted to the Department of Internal Medicine, Seoul National University Hospital during the 5 months period from March to July, 1970. They consisted of 14 males and 9 females. The age was ranged from 16 to 57 years, with mean age of 34.2. The patients included were bacteriologically (positive blood or stool culture) and serologically (Widal reaction above 1:160 in titer) confirmed cases and they did not take any antibiotic prior to admission. Bactrim was given orally 4 tablets daily in 2 divided doses for 14 days. Baseline studies including complete blood counts, urinalysis, stool examination, tests for bleeding tendency, liver function tests and bacteriologic sensitivity tests were done before administration of the drug and they were repeated at intervals 3 to 4 times thereafter by the time of discharge. E. K. G was also checked before and after treatment. Bactrim was effective in 21 (91.3%) out of 23 patients and the duration of fever after treatment was ranging from 3 to 7 days in responded cases. Treatment failure was considered to occur if fever did not subside within 10 days after initiation of therapy. There were 2 treatment failures. Two cases of relapse and one case of side reaction of the drug were noted in this study.
김영훈,김진호,박영태,이창홍,최인석 대한내과학회 1986 대한내과학회지 Vol.31 No.4
Bicarbonate secretion by the stomach may play a role in gastric mucosal protection, but there is limited information on the amount of bicarbonate secretion. We have therefore examined bicarbonate secretion in 9 normal adults and in 9 patients with duodenal ulcer, using a recently validated method utilizing measurements of gastric juice volume, hydrogen ion concentration and osmolality of gastric juice and plasma. The results are as follows: 1) In 9 healthy subjects, basal gastric bicarbonate secretion rate was 1.5±0.2 mmol/hr(mean±1 SE). After pentagastrin injection(6 mg/kg), the gastric bicarbonate secretion rate increased to 2.5±0.7 mmol/hr but the difference was not significant. 2) In 9 patients with duodenal ulcer, basal gastric bicarbonate secretion rate and gastric bicarbonate secretion after pentagastrin injection were 1.9±0.4 mmol/hr respectively. The difference was not significant, either. 3) The gastric bicarbonate secretion rates were not significantly different in the two groups either basally or after pentagastrin injection.