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RISS 인기검색어
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- 저자 : 하종영(Chong Young Ha) (검색결과 3 건)
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본태성 고혈압 환자의 치료경과에 따른 뇨중 N - Acetyl - β - D - Glucosaminidase 의 활성도
안중기(Joong Ki Ahn),이승호(Seung Ho Lee),하종영(Chong Young Ha),김원호(Won Ho Kim),고재기(Jae Ki Ko) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A The urinary excretion of N-acetyl-p-glucosamidase (NAG) is increased in patients whose renal function is impaired by a variety of kidney disease, and may provide an index of renal injury. To assess its role in essential hypertension, we measured urinary levels of NAG in 44 subjects with essential hypertension (and no evidence of renal disease), 14 subjects with well controlled hypertension and 41 normal control. NAG values were measured before therapy and after 2 months of antihypertensive therapy. The mean urinary NAG value (±S.E.) for the normo-tensive subjects was 31.6±2.42nmol hr-1mg creatinine-1. The mean value for the untreated hypertensive subjects was 121±9.09 (P<0.01). Systolic blood pressure was directly correlated with NAG levels. The urinary level of NAG in stage II hypertension (146±11, 16 nmol hr-1mg creatinine-1) was higher than that in the normal control (31.6±2.4nmol hr-1mg creatinine-1 , P<0.01), and stage I hypertension (81.8±8.49nmol hr-1mg creatinine-1, P<0.01). Fourteen patients followed for two months attained their ultimate blood pressure reduction within two months (from a mean of 176/110mmHg to one of 138/93mmHg), and therefore the urinary NAG level had changed significantly at two months (from 115,7±15.8 to 75.7±6.55, P<0. 05), These data suggest that NAG is frequently elevated in patients with high blood pressure even though there is no other evidence of renal damage, and that it can be reduced by successful antihypertensive therapy.
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간질환 환자에 대한 Ornithine Carbamyl Transferase(Preortan^�)의 임상 효과
하종영,이충섭,박태선,이승호,김대곤,안득수 의과학연구소 1988 全北醫大論文集 Vol.12 No.4
Twenty-six patients with liver diseases, such as acute and chronic hepatitis, toxic hepatitis, cirrhosis of the liver and hepatocellular carcinoma were included in this study, Fourteen of them received intravenous injection of Preortan 2,500 IU two times daily for 21 days and twelve patients received 500ml of saline enriched with 300mg of Vitamin C for the same period. Plasma values of alanine aminotransferase, aspartate aminotrasferase, total bilirubin, serum albumin, alkaline phosphatase and blood ammonia were determined weekle. In patients who received treatment with Ornithine-Carbamyl-Transferase, values of alanine aminotransferase, aspartate aminotransferase and total bilirubin significantly decreased, and the blood ammonia level in patients with cirrhosis of the liver also decreased significantly. But in Vitamin C treated group no significant decreases of alanine aminotransferase, aspartate aminotransferase, total bilirubin and blood ammonia were observed. (key words : Ornithine Carbamyl Transferase, Blood ammonia, Aminotransferase)
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만성 간염 환자에서 S-Adenosyl-L-Methionine 의 임상효과
안중기,하종영,김대곤,안득수 의과학연구소 1988 全北醫大論文集 Vol.12 No.1
전북 의대 부속병원 내과에서 입원 치료중이거나 외래에서 통원 치료를 받고 있는 간침생검상 만성 활동성 간염환자 8명과 임상적으로 만성 간염으로 추정되는 22명을 대상으로 SAMe와 Vit-C를 각각 30일간 매일 투여하여 다음과 같은 결과를 얻었다. SAMe 투여군 (n=21)에서 AST는 118.3±38.6U/L에서 71.4±25.2U/L로 (P<0.05), ALT는 263.14±69.3U/L에서 13.5± 57.3(P<0.01)로 통계학적으로 유의한 감소를 보였다. 21명중 16명에서 AST와 ALT의 지속적인 감소를 보였으며 5명에서는 투여 경과중 경도의 증가를 보였다. VIt-C 투여군 (n=9)에서는 투여 경과 중 유의하지 않는 증가 또는 감소를 보였다. 이상의 결과는 SAMe 투여로 만성 간염 환자군에서 76%의 치료 효과를 보여서 SAMe의 만성 간염 치료에 유용하게 사용될 것으로 사료된다.
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