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만성 B 형 간염환자에서 알파 인터페론의 용량에 따른 치료 효과
최예원(Ye Weon Choi),박승욱(Seung Wook Park),김규태(Kyu Tae Kim),조호준(Ho Jun Cho),고순희(Soon Hee Ko),김동규(Dong Kyu Kim),신호균(Ho Kyun Shin),김학양(Hak Yang Kim),박충기(Choong Kee Park),임규성(Kyu Sung Lim),유재영(Jae Young Yoo) 대한내과학회 1991 대한내과학회지 Vol.41 No.1
To assess the effect of different dosages of interferon alpha-2b(Intron A), 43 patients with chronic hepatitis B were assigned randomly to 3 groups: Group A, l5 patients, received Intron A in a dose of 3 million units (MU) thrice weekly for 12 weeks (total dosage: 1.8×108); Group B, 14 patients, received in a dose of 3 MU every day for the first month and thereafter every other day for the following 4 months (total dosage: 2.7×108); Group C, 14 patients, received no specific therapy. They included 34 men and 9 women, between 17 to 53 (mean 35) years of ages, with elevated serum AST and ALT levels; 41 to 879 (mean 289), and 57 to 334 (mean 288)U/L, respectively. Needle biopsies of the liver before therapy revealed chronic active hepatitis in 35 cases and active cirrhosis in 7 cases, The average follow-up period was 12 months. The results were as follows; 1) During the therapy, serum ALT levels returned to normal in 12 (80%) of Group A and in 12 (86%) of Group B, but increased again in 8 out of 12 in Group A, and in 4 out of 12 in Group B during the follow-up period, In Group C, the ALT level returned to normal in 3 out of 15 during the same period. 2) Serum HBeAg became negative in 6 out of group A in 11 out of Group B, but became positive again in 2 out of 6 in Group A and in 3 out of 11 in Group B during the follow-up period; The sero-negative conversion rate of HBeAg at the end of this study was 27 in Group A and 57% in Group B. In Group C, the sero-conversion of HBeAg was found in 2 out of 14 (14%). A statistically significant difference was noted between Group B and Group C (p<0.05). 3) Comparison of responders and non-responders in the treated group showed no differences in age, sex, liver fuction test, and tissue pathology. 4) Although flu-like symptoms (100%), loss of hair l (10%), and leukopenia (40%) were observed in the treated group, no serious side effects necessitating discontinuation of the therapy were observed. In conclusion, this study showed that the effect of interferon on patients with chronic hepatitis B might be different depending on the dosage and duration of therapy and that with increased dosage, the response rate could to be higher. But further studies should be carried out to determine the exact duration and dosage of therapy in these patients.
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