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      • KCI등재

        정제 제형 제조를 위한 포공영 추출물 함유 분말의 제조 및 평가

        진성규,Jin, Sung Giu 한국분말재료학회 (*구 분말야금학회) 2019 한국분말재료학회지 (KPMI) Vol.26 No.3

        To develop Taraxacum platycarpum extract (TP)-loaded particles for tablet dosage form, various TP-loaded particles composed of TP, dextrin, microcrystalline cellulose (MCC), silicon dioxide, ethanol, and water are prepared using a spray-drying method and fluid-bed-drying method. Their physical properties are evaluated using angle of repose, Hausner ratio, Carr's index, hardness, disintegrant time, and scanning electron microscopy. Optimal TP-loaded particles improve flowability and compressibility. Furthermore, 2% silicon dioxide gives increased flowability and compressibility. The formula of TP-loaded fluid-bed-drying particles at a TP/MCC/silicon-dioxide amount of 5/5/0.2 improves the angle of repose, Hausner ratio, Carr's index, hardness, and disintegrant time as compared with the TP-loaded spray-drying particles. The TP-loaded fluid-bed-drying particles considerably improve flowability and compressibility ($35.10^{\circ}$ vs. $40.3^{\circ}$, 0.97 vs. 1.17, and 18.97% vs. 28.97% for the angle of repose, Hausner ratio, and Carr's index, respectively), hardness (11.34 vs. 4.7 KP), and disintegrant time (7.4 vs. 10.4 min) as compared with the TP-loaded spray-drying particles. Thus, the results suggest that these fluid-bed-drying particles with MCC and silicon dioxide can be used as powerful particles to improve the flowability and compressibility of the TP.

      • KCI등재
      • KCI등재
      • 朝鮮時代 驛에 對한 一考察 : 深層的 硏究를 爲한 -試論-

        秦星圭 新羅大學校 1980 論文集 Vol.9 No.-

        Many of the studies on the history of Korea have been achieved in a political point of view, chiefly based on the histories of kingdoms. This type of study is likely to put an emphasis on the rulers, neglecting the common people, who were really the history makers. Keeping this point in mind, this study aims to tentatively study the post-station system of the Yi Dynasty the main role of which was the delivery of messages and taxes between the central and local governments as well as the transportation services. This study, while touching the general phases of the system, mainly took up the social status of those who were engaged in the post station, including the distribution and structures of the stations. It is revealed that the distribution of the post stations was rather partial towards the local powers. For example, a considerable portion of the stations were located in Kyeongsang Province, which was really powerful at that time. This partial distribution, as it was against the original role, surely provided a lot of inconveniences. The structures of the stations also varied with the provincial powers. The powerful provinces were able to have large-scaled stations and secure more personnel and land The most significant result of this study is that the post-station system, despite its indispensable role, gradually and constantly on the decliine. Various reasons for this could be given, such as the unfair profiteering of powerful clans, the heavy burden of serving traveling envoys, and the low status of the employees. The last was probably the chief reason for its declining. The station employees were not given any opportunities to be recognized or promoted.

      • KCI등재

        Mechanical properties, skin permeation and in vivo evaluations of dexibuprofen-loaded emulsion gel for topical delivery

        진성규,김정훈,Abid Mehmood Yousaf,손미윤,장선우,김동욱,김종오,용철순,최한곤 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.2

        The aim of this research was to evaluate the gelproperties, skin permeation and in vivo drug efficacy of anovel dexibuprofen-loaded emulsion gel for topical delivery. In this study, the dexibuprofen-loaded emulsion geland ibuprofen-loaded emulsion gel were prepared withisopropanol, Tween 80, propylene glycol, isopropyl myristateand carbopol. Their mechanical properties such ashardness and adhesiveness were assessed. Moreover, theirskin permeation, anti-inflammatory and anti-nociceptiveefficacy were evaluated using Franz diffusion cell with thehairless mouse skin, the carrageenan-induced paw oedematest and paw pressure test in rat’s hind paws compared withthe commercial hydrogel, respectively. The dexibuprofenemulsion gel and ibuprofen emulsion gel provided significantlyhigher hardness and adhesiveness than the commercialhydrogel. The dexibuprofen emulsion gel enhancedskin permeability by about twofold and 3.5-fold withoutlag time compared to the ibuprofen emulsion gel and thecommercial hydrogel, respectively, suggesting its fasterskin permeation. Moreover, the anti-inflammatory efficacyand alleviation in carrageenan-induced inflammation wasin the order of dexibuprofen emulsion gel[commercialhydrogel[ibuprofen emulsion gel. The dexibuprofenemulsion gel furnished significantly higher nociceptivethresholds than the ibuprofen emulsion gel and the commercialhydrogel, leading to the most improved anti-nociceptiveefficacy. Thus, this dexibuprofen-loaded emulsiongel with good mechanical property, rapid skin permeationand excellent anti-inflammatory and anti-nociceptive efficacywould be a strong candidate for the topical delivery ofanti-inflammatory dexibuprofen.

      • KCI등재
      • 圓鑑國師 沖止의 憂國精神

        秦星圭 新羅大學校 1982 論文集 Vol.13 No.-

        The invasion state of Mongolia has been studied so far respect of anti-Mongolia struggle, especially through research of Sambyulcho, (三別抄) but littler study has been made through Won-Gam-Rok(圓鑑錄) by Choongji(沖止)(1216-1293). Therefore, it is significant to look into real aspect of this society in launching of east expedition toward Japan at that age. In addition, this study is aimed at examining the role of Zen(禪) through Soo-Sun-Sa(修禪社) in the society under control of Mongolia. Soo-Sun-Sa produced 16 reverend priests(國師) since Bojo-Kuksa Jinul(普照國師知訥) and played a great role for Buddhism clearance movement in a place of Honam(湖南) area. Choongli who rose as 6th hand of Choge(曹溪) sect at that time not only played a great role in retaking the temple-farm (寺院田) occupied by Mongolia but also prayed to Buddha every night burning incense for peace of the nation when Kings Gojong(高宗) and Choongryul(忠烈王) frequented the royal family of Mongolia. At that time, of course, the Buddhism had been corrupted to the degree of last stage, and Choongji positively participated in society movement in an effort to prevent corruption in Buddhism. In that age, there were many temples named after sa(社) instead of sa(寺), and this was a result of society movement. When he served as chief of Soo-Sun-Sa, the hard living of people caused by invasion of Mongolia beyond the description, and they said that they could nor even taste soy bean during the 30-years invasion period of Mongolia. Most of the literary men in that age made a desperate effort to take a government post and did not turn an eye to the hard of life of people. That was the current of the age. Choongji, however, had shed tears many times seeing hardship of the people. His true character can be found in that. Around the year of accession to the throne of King Choongryul when the east expedition toward Japan was started, the ordinary people undertook the hardest work to build warships. All of the youngsters were movilized to seashore of Mongolian supervisors. Only children and old men remained in house, and all of the farmlands changed to waste lands. Choongji grown up in this circumstance had a feeling of sympathy that could not find in other people. This seems to have played a great role in forming his thought. Choongji who realized that the duty o priest was to same mankind prayed every night for peace of the nation.

      • KCI등재후보

        李承休의 佛敎觀

        진성규 진단학회 2005 진단학보 Vol.- No.99

        Born in the Age of the Military Rule of the Ch'oe and live through the political hardships due to the Chinese Y an Dynasty's interferences, Yi Sung-hyu(李承休 : 1224-1300) is best known as the writer of {Songs of Emperors and Kings : 帝王韻紀}and {Collection of Wandering Buddhist Hermit : 動安居士集}, both of which were written in Chinese character. Thanks to recent Korean translation of the {Songs of Emperors and Kings}, there have emerged about twenty five research articles on Yi Sung-hyu. Most of these studies focus either on the historiographical nature of {Songs of Emperors and Kings}, or on historical thought of Yi Sung-hyu. This artical is a result of my own translation of {Collection of Buddhist Hermit} Koryo Dynasty managed to maintain a balance between Confucianism as ruling ideology and Buddhism as way of mindful meditation. Though Yi Sung-hyu was fundamentally a Confucian scholar, he happened to enter into the world of Buddhism as a result of turmoils of his political careers. Nicknaming himself as a Wandering Buddhist Hermit, Yi devoted himself to reading Buddhist texts for ten years since 1280. His another book, {The Record of Internal Texts : 內典錄} which recorded abstracts of Buddhist texts, was a production of his personal attraction to Buddhism. Yi Sung-hyu's Buddhism showed the characteristics of Hermit Buddhism, which nourished the sense of self-satisfaction and self-comfort as a wisdom of suffering life. He also recognized 'Three Religious Doctrines and One Root Theory(三敎一源論), which emphasized that Confucianism, Buddhism, and Taoism were originated fro the same sources. This view of Hermit Buddhism was obviously influenced by Chinese Y an monk named Mongsandeokyi(夢山德異). 이승휴(1224∼1300)는 최씨 무인 정권 시대에 태어나 원의 정치적 간섭을 받던 13세기를 고뇌 깊게 살았던 인물이다. 한국역사상에 있어서 이승휴의 시대적 의미는 그의 저서 『제왕운기(帝王韻紀)』와 『동안거사집(動安居士集)』을 통해서 확인할 수 있다.지금까지 이승휴 연구 논문은 약 25편이 된다. 이 논문들은 대부분이 단군신화를 수록한 제왕운기가 갖는 사서(史書)로서의 성격을 연구하거나 이승휴의 역사인식문제를 주 관심의 대상으로 삼고 있는 것이 특징이다. 번역본 『제왕운기』 덕택이다. 번역본이 출간되기 전에는 1편의 논문 뿐인데서도 확인된다."이승휴의 불교관"은 필자가 그의 저서 『동안거사집』을 번역하면서 얻은 소산이다. 고려시대는 통치의 원리로 유학이, 신심의 수양으로 불교가 조화롭게 운용되던 사회였다. 그러나 이승휴의 본령(本領)은 유학자였다. 유학자였던 그가 불교 세계로 침잠하게 된 것은 그의 인생이 순탄하지 않은 탓이다. 좌천과 파직으로 전전하던 그가 동안거사라 자칭했듯이, 1280년경부터 10여년간 불경탐독이 시작되었다. 그러나 그가 읽었던 불경은 구체적으로 알 길이 없다. 불교 내용을 기록한 것으로 보이는 그의 저서 『내전록(內典錄)』이 기록으로 보일 뿐이다. 이승휴의 불교세계는 거사불교(居士佛敎)의 성격을 그대로 보여 주고 있다. 그의 불교적 성격은 개인적으로 자신의 수도에 정진하면서, 자기만족과 자기위안을 위한 불교신앙차원이었다. 거사불교로서 그가 인식한 불교세계는 삼교(三敎)인 유(儒)·불(佛)·도(道)가 한 근원이라는 삼교일원론(三敎一源論 : 유교 불교 도교가 한 근원이라는 의미)이다. 이런 불교관은 몽산덕이(夢山德異 : 원나라 승려 이름)의 영향이 큰 것으로 확인된다.

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