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      • 몇가지 Amine 體 Acetylcholine 及 Formalin 注射가 家兎 血淸 Haptoglobin 濃度에 미치는 影響

        池昌龍 최신의학사 1968 最新醫學 Vol.11 No.8

        Serum haptoglobin is a fraction in the alpha2 globulin which is characterized by its combining property with free hemoglobin. It was partially cleared by Jayle et al .2) to be a glycoprotein and latter it was demonstrated by Smithies3) that there are several genetic types by starch gel electrophoresis. These genetic types of haptoglobin have been intensively studied recently with special references to human biochemical genetics and anthropological view point 427) However. the exact physiological function of the haptoglobin is not clearly understood as yet. It is well known that serum haptoglobin level changes in various pathological conditions, for instance, its concentration increases in acute infection, reumatic affections, nephrosis, and carcinomatosis, and, on the contrary, it decreases in liver cirrhosis, hepatitis, and hemolytic anemia. In addition, serum haptoglobin level could be elevated experimentally in rabbit or guinea pig by adminstration of terpentine6i,61) or some proteolytic enzytic enzymes (papain, elestase etc) .63) However, the exact mechanism of such artificially induced hyperhaptoglobinemia is still unkown. The present work was undertaken to elucidate such mechanism and investigated the effect of histamine, serotonin, nor-epinephrine, epinephrine, acetylcholine and formalin adminstration on the serum haptoglobin level in rabbit. All the above described amine derivatives elevated serum haptoglobin level in rabbit, but very slightly compared to the terpentine adminstration. Acetylcholine had no effect on the serum haptoglobin level. On the other hand, subcutaneous adminstration of 10 ml of 4 per cent formalin induced remarkable hyperhaptoglobinemia comparable to the terpentine adminstration. The degree of hyperhaptoglobinemia produced by formalin was not related with the dosage and the number of adminstration. From these observations it was concluded that the. effect of formalin or terpentine on the serum haptoglobin level is not a direct one but an indirect action, and that such effect was not mediated through the action of histamine, serotonin, nor-epinephrine, epinephrine or acetylcholine. The possible role of adrenocortical hormone on the haptoglobin mobilization from the haptoglobin pool has been discussed.

      • SCOPUSKCI등재

        익사(溺死) ($WHO-E_{929},\;E_{934}$)의 역학적(疫學的) 관찰(觀察)

        지창용,김영춘,이병주,주인호,Chee, Chang-Yong,Kim, Young-Chun,Lee, Byung-Joo,Chu, In-Ho 대한예방의학회 1968 Journal of Preventive Medicine and Public Health Vol.1 No.1

        This paper describes the incidence and some epidemiological features of drowning accident out of a series of our study on the epidemiology of various accidents in Korea. By the daily press it is apparent from the frequent reporting of swimming accidents that the incidence would be high. In the rural areas, there are, at present, about 1,250 artificial lakes and farm ponds to be utlized for rice production. The reservoirs, irrigation ditches and riversides are also used for recreation. In most places facilities for aquatic activities is meager, and safety measures for the prevention of drowning is not sufficiently enforced. In the survey crude data on drownings were collected from the concerned governmental statistic books for the period 1955 to 1967 which were compiled not in a uniform way. Drownings were classfied into two categories, one is accidental drowning, E 929 and the other is due to cataclysm, E 934, according to the WHO international classification of diseases. Epidemiological variables in relation to drowning accident were obtained through qualitative analysis of informations from the popular news papers. The following summary may be drawn; 1. The average number of deaths due to accidental drowning totaled 1,088 annually and the mortality rate per 100,000 population was 3.4, The 42.0% of all drownings were rescued and the remaining were not saved. 2. The sex ratio (M/F) of the victims for all ages was 5 to 1, which had a wide range of difference among the age groups. The young ages less than 20 years occupied 68.0% of all deaths. 3. The percentage distribution of the causes of accidents revealed 31.9% for careless swimming, 45.5% for unskilled, 10.6% for swimmer's cramp and 6.0% for drunked. The distribution of places where accidents occurred showed 88.0% for rivers, water reservoirs, irrigation ditches and 12.0% for regular swimming pools. The seasonal distribution of cases indicated 85.0% of the total were seen during the summer months, June-August, and 50.0% of them occurred on Sundays, 4. The average annual deaths due to cataclysm were 402 and mortality rate per 100,000 population was 1.6, but the number of victims due to cataclysm varied greatly each year. 5. The accident cases due to cataclysm were classified into 60.0% for injuries, 40.0% for deaths. The 26.8% of all deaths were missing cases. 6. The deaths due to either accidental drowning or cataclysm totaled 1,490, and the death rate per 100,000 for the whole country was 5.0.

      • 最近의 自動車事故 및 이에 따르는 傷害患者에 對한 醫學統計學的 觀察

        池昌龍 우석대학교 의과대학 1970 우석의대잡지 Vol.7 No.2

        Currently the rapid progress of socio-economic status of the country has changed the leading causes of death. Particularly noticed is a reduction of infectious disease but an increase in traffic accidents. This paper describes statistical observations on the motor vehicle accidents for the whole country during the period, 1966-1968 and also medical observations on the 1,288,200 and 200 injured patients treated at various medical set ups in Seoul City for the years 1967-1969. The following summary is made: 1. Motor vehicle accident death rates per 100,000 population for the whole country were 6.7 in 1966, 7.15% in 1967 and 7.77% in 1968. This indicates an tendency of increase by year. Injury rates from motor vehicles per 100,000 also increased to such an extent as 64.19 in 1966, 84.49 in 1967 and 97.21% in 1968. The ratios of death to injury were 9.46 in 1966, 11.68 in 1967 and 12.51 in 1968, which show definite increases. 2. The increasing rates of motor vehicle accidents with baseline of 100 for the year of 1960, were231.6% in 1966, 349.9% in 1967 and 397.6% in 1968 and those for death for the corresponding years were 141.1%, 153.4% and 170.0% accordingly. The increasing rates of injury for the survey period were 214.2% in 1966, 286.8% in 1967 and 341.0% in 1960. 3. Comparing the frequency of accidents among the provinces, about a half of the total accidents for the whole country occurred in Seoul City. The number of traffic death in Seoul City, however, occupied only 8-12% of the total. 4. Monthly distribution of accidents indicated more cases in August and September, but less in December and January. 5. The age distribution of motor vehicle drivers involved in accidents showed that 31.94% for the age group 26-30% years, 22.25% years and 20.12% for 31-35 years. 6. Comparing the frequency of motor vehicle accidents, business car occupied about 60%, private car occupied about 30%, government car occupied about 8% and the number of accidents by year, business car decrease a little, but private car increase more than last year. 7. The frequency of traffic injuries by medical diagnosis revealed that contusion and crushing(N920-929) occupied 72.59% of the total injured patients, and concussion(N850-854) 8.38%, fractures of the lower limb(N820-829) 5.53%, fractures of the skull, spine and trunk(N800-808) 4.50%, fractures of the upper limb(N810-816) 3.10% and so forth. 8. The frequency of fracture showed that 26.04% for fracture of the tibia and fibula(N823), 13.02% for base of skull(N801), 9.47% for the rib, sternum and larynx(N807) and 8.88% for pelvic fracture. 9. The duration of treatment of the injured by week period were:one week 32.50-45.50%, two weeks 25.00-30.00%, 3 weeks 10.00-13.22%, 4 weeks 2.00-9.50% and 5 weeks and longer 12.50-21.00%. The period of treatment for the fracture patients were more than 3 weeks on the average and it further breakdown; 1-5 weeks and more for concussion, 2-3 weeks for laceration and open wound at the head, neck and trunk;less than 1-2 weeks for contusion and crushing with intact skin surface.

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