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단일벽 탄소 나노튜브의 흡광도 신호를 이용한 DNA 결합 측정
조승범(Chengfan Cao),윤도경(Dokyung Yoon),최재붕(Jae-Boong Choi),김영진(Young-Jin Kim),백승현(Seunghyun Baik) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
Single walled carbon nanotubes(SWCNTs) can be applied for biomolecular sensors and/or markers due to their small size and excellent optical properties such as near infrared fluorescence and absorption. Here, we put out an optical biosensor using absorption signal of SWCNTs to detect DNA hybridization. SWCNTs exhibit sharp absorption peak distributions at different wavelengths when they exist in a well-dispersed solution state. It is found that DNA hybridization results in red peak shifts of nanotubes in the near infrared region. Compared to metallic species, semiconducting SWCNTs show manifest variations. The findings in this work make SWCNTs be used to selectively recognize various DNA interactions.
탄소 나노튜브와 생체 분자와의 결합을 통한 나노-바이오 응용
황응수(Eung-Soo Hwang),조승범(Cao Chengfan),홍상현(Sanghyun Hong),정혜진(Hye-Jin Jung),차창용(Chang-Yang Cha),최재붕(Jae-Boong Choi),김영진(Young-Jin Kim),백승현(Seunghyun Baik) Korean Society for Precision Engineering 2006 한국정밀공학회지 Vol.23 No.3
Single-walled carbon nanotubes (SWNT) exhibit strong Raman signals as well as fluorescence emissions in the near infrared regions where most biomolccules arc transparent. Such signals do not blink or photoblcach under prolonged excitation, which is advantageous to optical nano-bio marker applications. In this paper, single walled carbon nanotubes are conjugated with specific types of single-stranded DNA in order to detect oligonucleotides of corresponding complimentary sequences. Dot blotting experiments and comparative Raman spectroscopy observations demonstrated excellent sensitivity and specificity of carbon nanotube-DNA probes. The results show the possibility of using SWNT as generic nano-bio markers for the precise detection of specific kinds of genes.