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조성희,이주훈,조영미,박영서,정해일,Cho, Sung-Hee,Lee, Joo-Hoon,Cho, Young-Mi,Park, Young-Seo,Cheong, Hae-Il 대한소아신장학회 2009 Childhood kidney diseases Vol.13 No.2
저자들은 1세 이하에 발병한 신증후군 환아 7명의 진단 및 치료를 경험하였기에 보고하는 바이다. 1996년부터 2007년까지 본원에서 1세 이전에 신증후군으로 진단 받은 환아 7명을 대상으로 병록 고찰을 통해 후향적으로 조사하였다. 선천성 신증후군은 3명, 영아형 신증후군은 4명 이었고, 남아가 1명, 여아가 6명으로 여아가 많았다. 6명에서 신생검을 시행하였고, 2명에서 미만성 메산지움 경화증, 2명에서 국소분절사구체경화증, 1명에서 Finnish형 신증후군 그리고 나머지 1명에서는 미세 변화형으로 확인되었다. 4명의 환아에서 NPHS2, PLCE1, 그리고 WT1의 유전자 분석을 시행하였고 2예에서 WT1 변이가 확인되었다. 선천성 신증후군으로 진단받은 3명 중 1명은 Finnish형 신증후군, 2명은 DDS로 진단받았고, 3명 모두 패혈증으로 사망하였다. 영아형 신증후군으로 진단받은 4명 중 2명은 사망하였고, 다른 1명은 관해가 되어 치료되었고, 나머지 1명은 치료 4개월 경 말기 신부전으로 진행하여 복막투석을 하고 있다. 1세 이전에 발병하는 선천성 신증후군은 소아 신증후군에 비하여 예후가 나쁘지만, 병력의 세밀한 검토, 임상소견 및 조직검사, 유전자 분석을 통한 정확한 진단이 빠르게 이루어져 조기 투석 및 신이식 등 적극적인 치료를 한다면 생존률의 향상을 기대할 수 있을 것이다. 대부분의 1세 이전 진단받는 신증후군은 유전적 신질환으로 추후 이들 환아들에 대한 유전형-표현형의 상관관계에 대한 추가 연구가 필요하다. Purpose : This study was performed to report the diagnosis and treatment of nephrotic syndrome manifesting in the first year of life. Methods : We retrospectively reviewed the clinical data with chart review in 7 patients who were diagnosed as nephrotic syndrome manifesting in the first year of life from 1996 to 2007. Results : Three patients had congenital nephrotic syndrome, the other 4 patients had infantile nephrotic syndrome. Their ages ranged from birth to 11 months and male to female ratio was 1 to 6. Renal biopsies were done in 6 patients. One patient had Finnish type congenital nephrotic syndrome, 2 patients had diffuse mesangial sclerosis, 2 patients had focal segmental glomerulosclerosis and 1 patient had minimal change disease. Genetic analyses of NPHS2, PLCE1, and WT1 were done in 4 patients and 2 of them had WT1 mutation. Among 3 patients with congenital nephrotic syndrome, 1 patient was diagnosed as congenital nephrotic syndrome of Finnish type and the other 2 patients were diagnosed as Denys-Drash syndrome. All of the patients with congenital nephrotic syndrome died due to sepsis. Among 4 patients with infantile nephrotic syndrome, 2 patients died and 1 had remission, another patient progressed to end stage renal disease. Conclusion : Most of nephrotic syndrome manifesting in the first year was hereditary renal disease. Patients with nephrotic syndrome manifesting in the 3 month of life had poorer prognosis and needed more aggressive management including early dialysis and renal transplantation might be considered compared with infantile nephrotic syndrome. Further genotype-phenotype correlation studies are needed.
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조성희,손진희,Cho, Sung-Heui,Son, Jin-Hee 한국주거학회 2005 한국주거학회 논문집 Vol.16 No.6
It is possible to explain the design, the meaning, and the use of domestic space by comparing different cultures. The characteristics of Koreans' housing life living in western cultures has already been studied extensively. Because of political reasons, however, the characteristics of Koreans' housing life living in Chinese culture has hardly been studied at all. The purpose of this study was to find out the characteristics of succession and transformation of domestic housing culture. The data was collected by questionnaire methods from fifty Korean households and eleven Chinese households. Individual interviews and actual surveys, including taking pictures were also used for data collection. The results of this study were as follows (1)An analysis of heating system usage behaviors showed the importance of heated floors, known as Ondol, is one of the enduring characteristics of domestic habits. (2)In the sitting style, the traditional sitting on the floor was shown in living room. (3)Regarding room usage behavior, Korean households were centered around the living room in chinese houses. (4)An analysis of space organization preferences with respect to common spaces revealed that Korean households tend to prefer the open plan of common spaces.
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레니텍<sup>®</sup> 정(말레인산 에날라프릴, 10 mg)에 대한 에나레이스 정의 생물학적 동등성
조성희,하용화,홍성제,서성훈,류재환,김동현,이경태,Cho, Sung-Hee,Ha, Yong-Hwa,Hong, Sung-Je,Seo, Seong-Hoon,Rew, Jae-Hwan,Kim, Dong-Hyun,Lee, Kyung-Tae 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3
The purpose of the present study was to evaluate the bioequivalence of two enalapril maleate tablets, $Renitec^{TM}$ (MSD Korea Ltd.) and $Enalace^{TM}$ (Welfide Korea Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $22.33{\pm}2.55$ year in age and $66.54{\pm}8.30$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 10 mg of enalapril maleate per tablet were orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;and\;C_{max}$ untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log0.8 to log1.25$(e.g.,\;log1.02{\sim}log1.14\;and\;log1.03{\sim}log1.19\;for\;AUC_t\;and\;C_{max},\;respectively)$. The major parameters, $AUC_t,\;and\;C_{max}$, met the criteria of KDFA for bioequivalence indicating that $Enalace^{TM}$ tablet is bioequivalent to $Renitec^{TM}$ tablet.
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Gluconoacetobacter hansenii에 의해 생산된 섬유소 섭취가 흰쥐의 소화기관과 지질대사에 미치는 영향
조성희(Sung-Hee Cho),이지연(Ji-Yeon Lee),최영선(Young-sun Choi),최경호(Kyung-Ho Choi) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.5
본 실험은 초산균인 Gluconoacetobacter hansenii에 의해 코코넛 배지에서 생성된 막인 bacterial fiber가 흰쥐의 장 전반과 소장의 이당류 효소활성 및 체내 지질상태에 미치는 영향을 조사하였다. 이를 위하여 흰쥐를 0.5% 콜레스테롤 식이로 사육하였으며 섬유소원으로 bacterial fiber를 식이의 2%로 첨가하였으며, 효과를 비교할 실험군들에게는 섬유소원으로 식물성 cellulose와 pectin을 같은 수준으로 식이에 첨가하여 사육하였다. 실험 4주간 동안 식이섭취량 및 체중 증가량은 세 군간에 차이가 없었다. 소장의 길이, 무게 등은 군간에 유의적인 차이는 없었으나 소장점막 sucrase활성이 bacterial fiber군에서 감소하였고, maltase 활성도 감소하는 경향이었다. 맹장의 무게가 bacterial fiber군에서 증가하였으나, 결장의 무게에는 영향이 없었고, 결장 내용물 및 건조분변량이 감소하였다. 혈장 총 콜레스테롤 농도는 세 군 중에서 pectin군이 유의적으로 낮았고 HDL-콜레스테롤 함량은 반대로 pectin군에서 높았다. 혈장과 간조직의 중성지방 함량은 모두 bacterial fiber군에서 다른 군들에 비하여 유의적으로 낮았다. 간조직 콜레스테롤 함량은 pectin군에서 낮았다. 간조직의 상대적 무게는 군간에 차이가 없었고, 혈장 GOT 및 GPT 활성도 bacterial fiber군에서 다른 두 군에 비하여 차이가 없었다. 본 연구의 결과, 실험에서 사용한 bacterial fiber는 체내의 중성지방 수준을 낮추어 지질 상태를 개선 할 수 있는 가능성을 보여 주어 이에 대한 기전과의 작용의 활용에 대한 연구가 요망된다. 본 실험에서는 콜레스테롤 및 소장의 구조와 소화효소에는 큰 영향을 주지 않았으나 사용하는 섬유소의 수준을 보다 높이거나 다른 섬유소와 복합적으로 사용하는 경우, 또 동물의 나이에 따라 다른 결과가 도출될 수도 있으리라고 사료되어 앞으로의 지속적인 연구가 필요하다. This study was conducted to see effects of dietary bacterial fiber produced by Gluconoacetobacter hansenii on gross structure, and disaccharidase activities of small intestine and body lipid status in rats. Bacterial fiber was prepared by drying and alkali treatment of floating membrane produced 15 days after the bacterial culture using coconut juice media. Male Sprague-Dawely rats of 320±10 g were grouped into three and fed 0.5% (w/w) cholesterol diets with three different dietary fibers, i.e. cellulose, and pectin and bacterial fiber, at the level of 2% (w/w). During four-week experimental period, food intakes and body weight gains were not different among three groups. Total lengths and jejunal fragment weights of small intestine did not differ among the three groups but cecal weight was higher in bacterial fiber groups than those of the other two groups. Colon content and fecal dry weight were lower in bacterial fiber group. Sucrase activity of the jejunal mucosa was lower in bacterial fiber group but maltase activity was not different from those of the other two groups. Plasma total cholesterol level was lower and that of HDL-cholesterol higher in pectin group than those of cellulose and bacterial fiber groups, the latter of which did not differ. Both in plasma and liver triglyceride levels were lower in bacterial fiber group than cellulose and pectin groups, and liver cholesterol level was lower in pectin group. Relative liver weights and plasma activities of GOT and GPT were not different among three groups. It is concluded that bacterial fiber used in the present study had hypotriglyceridemic effect that help improve lipid status in the body.
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UTAUT 모델을 응용한 패션 증강현실(FAR) 기술수용에 관한 한국 20대 여성의 소비자 태도, 기술 사용의도 및 구매의도
조성희 ( Sung Hee Cho ),김칠순 ( Chil Soon Kim ) 한국의류학회 2019 한국의류학회지 Vol.43 No.1
This study determined the impact of ‘Fashion Augmented Reality (FAR)’ acceptance factors based on the model of acceptance and use of technology (UTAUT) on consumer attitudes, intention to use technology, and fashion product purchase intention. A survey asked participants to have an AR experience using a FAR app to understand FAR in advance. Data were analyzed factor analysis and stepwise regression using SPSS. The results are as follows. First, the factor analysis classified the acceptance variables of FAR technology into ‘social relations’, ‘shopping effectiveness’, and ‘easy to use FAR’. Second, among the three factors of FAR acceptance, ‘shopping effectiveness’ is statistically more influential on positive attitudes towards FAR. However, ‘easy to use’ factor was more influential on ‘the intention to use technology’ as well as ‘purchase intention’. Third, ‘social relations’ were identified as an important factor affecting ‘consumer attitudes’, ‘intention to use technology’ and ‘purchase intention’ which are not well covered in fashion technology research. In addition, ‘the intention to use technology’ was found to be influential on ‘purchase intention’ and indicated the importance of easiness of FAR to enhance purchase intention.
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