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줄기세포 전달을 위한 생분해성 마이크로로봇의 대량 제작
노승민(Seungmin Noh),전성웅(Sungwoong Jeon),김은희(Eunhee Kim),김진영(Jin-young Kim),최홍수(Hongsoo Choi) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Microrobots have shown various clinical applications, from drug delivery to stem cell delivery. However, long fabrication time and nonbiodegradable materials were disadvantages of microrobot fabrication. Here, we introduce the mass-producible fabrication process of microrobot composed of gelatin methacrylate (GelMA), photoresist, and magnetic nanoparticles. Due to the fabrication characteristics of droplet generation, around 120 microrobots could be made within a minute. The stem cell attachment to the surface of the GelMA microrobot was observed 24h after the coculture. The cell-loaded microrobot could be actuated by the external magnetic field generated from the magnetic actuation system. As the GelMA is a biodegradable hydrogel, the microrobot could be degraded by the enzyme, and the released stem cells from the cell-loaded microrobot could be attached to the substrate. The introduced biodegradable microrobot could make a breakthrough in stem cell therapy.