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중이염 치료용 암피실린 - 폴리락트산 필름의 약물방출조건
지웅길,나성범,정서영,박기동,전성균,구현철,양승은 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.1
A new local drug delivery device to treat otitis media (OM) has been developed. This device consists of a biodegradable poly(L-lactic acid) (PLLA) film containing antibiotic (ampicillin, AMP), which can be placed into the middle ear cavity and release the therapeutic concentration of AMP for prolonged period. Biodegradable films containing AMP (10 w/w%) were prepared by solution casting method using a suspension of the drug in a PLLA/CH₂Cl₂ solution (molecular weight of PLLA, 100,000 (100 K) and 300,000 (300 K), respectively). PLLA-AMP films were characterized by FTIR, DSC, and SEM. In vitro release of AMP from AMP-PLLA films were examined. The release pattern of AMP from AMP-PLLA films remained consistent from 1 day to 14 days, and the release rates of AMP from AMP-l00K-PLLA film and AMP-300K-PLLA film were 0.7384 ㎍/㎖/day, 0.4107 ㎍/㎖/day, respectively.