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미니피그에서 임플란트 주위의 골결손부에 대한 I형 콜라겐, 조골세포 및 PTH의 골형성 효과
이준 ( Jun Lee ),장재덕 ( Jae Deog Jang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Effect of type I collagen, osteoblast and PTH mixture on bone formation of the bony defects around implant in minipigs. Mesenchymal stem cells derived from adult bone marrow are multipotent cells capable of differentiating along several lineage pathways. Cell-driven approaches, especially the biophysical stimulation of the host cell population surrounded by the bone defect, are common treatment methods in maxillofacial surgery. Others, such as autogenous cell implantation, have now gained acceptance for clinical trials. All of the cell-driven repair strategies are under intensive investigation in an effort to provide surgeons with a limitless supply of tissue for bone repair and reconstruction in future procedures. An overview of the basic biological aspects as well as the inherent constraints of different cell-based approaches are given in this paper. The aim of this study was to evaluate the bone formation effects of mesenchymal stem cells & PTH as a cytokine in bone defects around implants in Minipig models. Ten minipigs were divided into 4 groups. We made 4 wall-defects(10 mm in diameter, 8 mm in height) on the lower jaw, and the following materials were applied: fibrin glue as control and type I collagen, type I collagen + osteoblast, and type I collagen + osteoblast + PTH as experimental groups. Each defects were implanted with 3 mm wide and 8 mm long implants in center. Experimental minipigs were sacrificed at 1, 2, 4, 8 and 12 weeks after operation. We evaluated the defects clinically, histologically and histomorphologically(bone implant contact). The results were as follows; (1) Osteogenesis in Type I collagen mixed with osteoblast and osteoblast with PTH groups was more active than control group. (2) Most experimental groups, especially the PTH group, at 4 weeks to 8 weeks, showed larger amount of bone implant contact increase than control group.
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토끼 전완부 요골 결손 부위에 자가 이식된 골모세포의 골형성능
김석중(Seok-Jung Kim),장정호(Cheong-Ho Chang),장재덕(Jae-Deog Jang),이승구(Seung-Koo Lee),박원종(Won-Jong Bahk),인용(Yong-In),윤형문(Hyung-Moon Yoon) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.1
목적: 골모세포를 해면골과 골수에서 분리한 후, 이를 다량으로 배양하여 골 결손부위에 이식하였을 때, 이 부위에 안정성을 부여해 줄 수 있는 골조직을 형성하는가를 보고자 하였다. 대상 및 방법: 뉴질랜드 백색 토끼 20마리의 전완부의 요골 간부에 15 ㎜ 정도의 골결손 부위를 만들었다. 실험군 10마리는 토끼의 장골에서 해면골과 골수을 채취하여 여기서 골모세포를 분리한 후 배양하여, 이를 골결손을 만든 후 3주째에 결손 부위에 주사기로 주입하였다. 대조군 10마리는 토끼의 장골에서 해면골을 얻어 이를 골결손 부위에 이식하였다. 실험 후 3주, 6주 및 9주에 방사선 촬영을 하였고, 9주에 토끼를 희생시켜 조직을 얻었다. 결과: 실험군에서 정상 골조직의 형성을 보이고 있으며 방사선 검사상 골결손 부위에 골형성이 관찰되었다. 대조군과 비교하여 비슷한 골형성의 시기 및 유합속도를 보였으며 조직 검사상 비슷한 정도의 골형성이 관찰되었다. 결론: 골결손 부위에 자가 이식 된 골모세포는 골화를 유도함을 확인 하였다. 향후 골이식이 필요한 여러 상황에 적용할 수 있을 것이라 기대된다. Purpose: To evaluate the osteogenic potential of an autologous cultured osteoblast transplant to the bone defects. Materials and Methods: Radial bone defects over 15 ㎜ were made in 20 New Zealand white rabbits using the anterior approach. There were 10 rabbits in the control group, which underwent an iliac bone graft to the preformed bone defect 3 weeks from the initial operation. There were 10 rabbits in the experimental group that underwent an autologous cultured osteoblasts injection. After 9 weeks, both groups were compared radiologically and histologically. Results: The osteogenesis in both groups were progressed similarly and there was no difference in terms of the amount of bone formation and the duration of the bone union. Conclusion: An autologous cultured osteoblast transplant to the bone defect produces bone efficiently. In addition, it can be applied to a wide field, which requires a bone grafting operation.
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가토에서 자가유래 골아줄기세포를 이용한 상악동 골 이식술시 비계체로서 Bio-Oss의 효과에 관한 연구
이준(Jun Lee),성대혁(Dae-Hyuk Sung),최재영(Jae-Young Choi),최성림(Sung-Rym Choi),차수련(Su-Ryun Cha),장재덕(Jae-Deog Jang),김은철(Eun-Chul Kim) 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.5
Mesenchymal stem cells (MSCs) have been though to be multipotent cells that can replicate that have the potential to differentiate into lineages of mesenchymal tissue including the bone, cartilage, fat, tendon, muscle, and marrow stroma. Especially, scaffolds to support cell-based tissue engineering are critical determinants of clinical efforts to regenerate and repair the body. Selection of a matrix carrier imvolves consideration of the matrix’s role as a scaffold for physical support and host tissue integration as well as its ability to support of synergize the osteoinductive program of the implanted mesenchymal stem cell. The aim of this study is to evaluate the effect of autobone and Bio-Oss to adherent mesenchymal stem cells as scaffolds on sinus augmentation with fibrin glue mixture in a rabbit model. 16 New Zealand White rabbits were divided randomly into 4 groups based on their time of sacrifice (1, 2, 4 and 8 weeks). First, mesenchymal stem cells were isolated from iliac crest marrow of rabbits and expanded in vitro. Cell culture was performed in accordance with the technique described by Tsutsumi et al. In the present study, the animals were sacrificed at 1, 2, 4 and 8 weeks after transplantation, and the bone formation ability of each sides was evaluated clinically, radiologically, histologically and histomorphologically. According to the histological observations, autobone scaffolds group showed integrated graft bone with host bone from sinus wall. At 2 and 4 weeks, it showed active newly formed bone and neovascularization. At 8 weeks, lamellae bone was observed in sinus graft material area. Radiologically, autobone with stem cell showed more radiopaque than Bio-Oss scaffolds group. there were significant differences in bone volume between 4 and 8 weeks (p<0.05).
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