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한국인 건선 환자에서 narrow band UVB 에 의한 최소홍반량
임종현(Jong Hyun Rim),최용범(Yong Beom Choe),윤재일(Jai Il Youn) 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.8
N/A Background: In planning narrow band UVB (NBUVB) phototherapy protocol, assessing a minimal erythema dose (MED) of NBUVB may be essential to gain optimal therapeutic results. However, there are few data regarding to the MED of NBUVB in Koreans and the results are variable according to skin types and photosensors. Objective: We assessed MED of NBUVB in psoriasis patients by a photometer designed for NBUVB phototesting, the relationship of skin type and ultraviolet responses. Methods: Forty psoriasis patients were phototested on their backs with newly developed Waldmann UV meter(Waldmann Co. Germany) for NBUVB phototesting. The MED was investigated by irradiating several NBUVB doses ranging from 200 mJ/cm to 1500 mJ/cm' and then was judged visually 24 hours after. Results 1. The median and mode value of MED of NBUVB in Korean psoriasis patients were 950 mJ/cm²(35%). 2. Skin type was well correlated with the MED. Conclusion: The MED value of NBUVB in our study may be useful data to set the phototherapy protocol. Skin types are related with MED value and the study is more required to know the exact relationship. (Korean J Dermatol 2001;39(8) . 883-886)
Narrow Band UVB 를 이용한 건선의 광치료에서 광량 증가방법에 관한 연구
최용범(Yong Beom Choe),임종현(Jong Hyun Rim),윤재일(Jai Il Youn) 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.6
N/A Background: Narrow-band UVB phototherapy using 311+2nm wavelength is in widespread use due to its greater efficacy and, possibly, safety compared with broad-band UVB sources. However, its optimal dose increment regimen is not determined. Objective: We performed narrow-band UVB(NBUVB) phototherapy to compare clinical efficacy between fixed and 20% incremental regimen in Korean psoriasis patients. Methods: Twenty four psoriasis patients received narrow-band UVB phototherapy. Among them, fifteen patients received fixed regimen and nine patients, 20% incremental regimen. We categorized each patient into clearing, improvement, or failure groups based on the therapeutic efficacy, measured the PASI score every two weeks and calculated cumulative dose of narrow-band UVB. Results : We found no statistically significant difference between two regimen. However, there is a tendency that irradiation number and duration of treatment are smaller in 20% incremental regimen but, in terms of cumulative dose, fixed incremental regimen is better than 20%. Conclusion : These results suggests that 20% incremental regimen may clear psoriasis faster than fixed but that the latter regimen may be equally effective as it requires slighty more treatment sessions at a lower cumulative dose. (Korean J Dermatol 2001;39(6): 671~675)
애완동물로부터 감염된 환자 및 애완동물에서 분리된 T. mentagrophytes 의 internal transcribed spacer 1 ( ITS1 ) 염기서열 분석
김정애(Jeong Aee Kim),임종현(Jong Hyun Rim),문상은(Sang Eun Moon),김규한(Kyu Han Kim),조광현(Kwang Hyun Cho) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.10
N/A Background: Trichophyton mentagrophytes is a complex species and 3 perfect states, Arthroderma benhamiae, A. vanbreuseghemii, and A. simii have been described. In Korea and Japan, all of the isolates of T. mentagrophytes of which the perfect states determined were known as A. vanbreuseghemii till recently. However, in Japan, one isolate from a monkey was reported as A. simii and several strains from rabbits or patients were A. benhamiae. Therefore, it is necessary to confirm the existence of A. simii or A. benhamiae in Korea. Objectives: We performed this study to determine the teleomorphs of 19 strains of T. mentagrophytes isolated from Korean patients infected from pets and 4 from the skin lesions of rabbits. Metbods: DNA sequences of internal transcribed spacer 1 (ITS1) area of the 23 isolates and 3 reference strains were determined and matched with the data registered in GenBank nucleotide sequence database. Results: The sequencing data of 22 isolates were very similar to those of A. vanbreuseghemii and 1 to T, mentagrophytes var. interdigitale respectively. Conclusion '. Although all of the clinical isolates were related with A. vanbreuseghemii in this study, the possibility of the existence of A. simii and A. benhamiae in Korea is still high and further study is needed. (Korean J Dermatol 2001;39(8): 1086-1093)
뇌경색으로 인한 편측 마비 후 마비 부위에서 호전된 건선 1 예
윤재일,최용범,임종현 대한피부과학회 2001 대한피부과학회지 Vol.39 No.1
The role of the nervous system in the pathogenesis of psoriasis has been receiving increasing attention. We report a case of improvement of psoriasis after hemiparesis following cerebrovascular accident. This case is worthy in that it supports the neurogenic origin of psoriasis.