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이하늬,김택현 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
Amines are highly versatile building blocks in natural products, pharmaceuticals, and agrochemicals. Reductive amination is one of the most powerful used methods for accessing different kinds of amines, in particular, when the carbonyl component is reacted directly with the amine and reducing agent, avoiding isolation of the imine intermediate. Isothiouronium salts have been explored recently as a new class of hydrogen-bonding subunit as thiourea. Isothiouronium group has more advantages: it enhances the NH acidity compared to the corresponding thiourea. Herein, we will discuss the effect of S-benzyl isothiouronium salts as an activator in the reductive amination of aldehydes from the viewpoint of the reaction rate depending on the counter anion of these salts.
이하늬,박정숙,Lee, Ha-Nui,Park, Jeong-Sook 한국콘텐츠학회 2022 한국콘텐츠학회논문지 Vol.22 No.10
The purpose of this study was to develop evidence-based practice guideline for rapid response to acute deterioration of hospitalized patients. The guideline was developed according to the Clinical Practice Guideline Adaptation Manual. and evaluated using AGREE II tool. The guidelines were checked content validation by an expert group, final 130 recommendations in 5 sections including management, recognition, activation, response, and evaluation. The average of the overall practical application to the guidelines was 4.41±0.78 out of 5, which showed high applicability in clinical work.