Sulfa 劑 投與가 白鼠營養에 미치는 影響

李載瓚 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.1

Sulfa 劑 投與가 白鼠營養에 미치는 影響 : 體成分 變動에 對하여

李載瓚,黃祐翊 우석대학교 의과대학 1971 우석의대잡지 Vol.8 No.1

This study was carried out to observe some of the nutritional effect by feeding sulfadimethoxine with or without thiamine supplement in rats. The male albino rats from a pure strain, weighing 205-246g, were used for the experimental animals. They were divided into three diet groups; the standard, the high carbohydrate and the high protein diet group. A half part of the each group of the animals was fed with sulfa drug, 150㎎/㎏ sulfadimethoxine, prior to feeding each morning meal once a day, whereas therest of them was fed with same amount of the sulfa drug supplemented with 1.5㎎/㎏ of thiamine HCl. The animals maintained with above-mentioned dietary conditions were sacrificed on the 4th hour. 1st, 3rd, 7th and 15th day after feeding. The nitrogen, lipid and cholesterol contents in the liver, kidney, small intestine and blood, and the hemoglobin and hematocrit values in the blood were measured. The results obtained are summarized as follows; Ⅰ. The effect of dietary difference: 1. The nitrogen content in the kidney was increased by feeding the high carbohydrate and the high protein diet compared with the standard diet. 2. The lipid contents in the liver and the plasma were increased by feeding the high carbohydrate and the high protein diet compared with the standard diet, whereas the lipid contents in the kidney and the small intestine were decreased during feeding the high carbohydrate diet. 3. The cholesterol contents in the liver and the plasma were more increased by feeding the high carbohydrate diet than the standard diet. Ⅱ. The effect of feeding the sulfa drug. 1. The nitrogen content in the kidney was more increased by feeding the standard diet with the sulfa drug than the control group, whereas the animals fed the high carbohydrate diet with the sulfa drug showed decreasing tendency from 3 to 15 days after feeding. 2. The lipid contents in each organ were significantly increased on 4th hour after feeding the standard diet with the sulfa drug, compared with their control group, and the content in each organ was generally increased by feeding the high carbohydrate with the sulfa drug. 3. The cholesterol contents in the small intestine and the plasma were generally increased by feeding each diet with the sulfa drug, compared with their control group. 4. The changing of the hemoglobin and hematocrit value were shown similar tendency by feeding the sulfa drug compared with their control group. Ⅲ. The effect of feeding the sulfa drug with thiamine HCl. 1. The lipid contents in the liver and the plasma were generally increased by administering the sulfa drug with thiamine HCl, compared with their control group, whereas the content in the kidney was decreased. 2. The cholesterol content in the kidney was shown increasing tendency by administering the sulfa drug with thiamine HCl, compared with their control group, whereas the content in the plasma showed increasing tendency. As above results, dietary conditions and administration of the sulfa drug had shown significant influence on the change of the chemical composition of some abdominal organs, while simultaneous administration of the sulfa drug supplemented with thiamine HCl had shown less effect on them.

(Pb, Ba) (Zr, Ti)O3계의 확산된 상전이에 있어서 Strain Energy의 역할

이재찬,주웅길 한국세라믹학회 1987 한국세라믹학회지 Vol.24 No.6

The role of the strain energy and phase stability in the diffuse phase transition have been investigated in the highly disordered solid solution, (Pb1-xBax)(Zr0.4Ti0.6)O3 (0.2 x 0.4). X-ray diffraction analysis indicates that tetragonality (c/a) decreases with the increasing Ba content. Also as the Ba content increases, phase transition becomes more diffuse and at the same time dielectric relaxation as a function of measured frequencies in the 1KHz-10MHz range occurs very pronouncedly. In the Ba content range, 0.2 x 0.35, hysteresis loops are routinely observed and the loop is observed to narrow shape as the Ba content increases but becomes very slim at 40mol% Ba content. Moreover thermal analysis shows that there is no abrupt change in the thermal expansion coefficient below the apparent transition temperature at which dielectric constant becomes maximum. From the above results, it has been concluded that creation of the strain energy due to the distorthion that occurred during the phase transition suppresses diffuse phase transition.

발효 및 효소반응을 통한 DFAIII의 생산 및 회수

이재찬,이기영,송기방,이용복,Lee, Jae-Chan,Lee, Gi-Yeong,Song, Gi-Bang,Lee, Yong-Bok 한국생물공학회 1999 KSBB Journal Vol.14 No.5

의 대량생산과 분리.정제 기술의 개발을 위해 Arthrobacter ureafaciens KCTC 3387 균주를 이용한 발효 및 분리정제된 효소반응을 통한 DFAIII의 생산과 회수에 대하여 조사하였다. 첫 번째 방법으로는 Arthrobacter ureafaciens 균주를 발효배양하여 DFAIII 양이 최고가 되는 시점에서 발효정지 시킨후 silica gel를 통해 gel filtration을 분리하였고, 두 번째 방법으로는 정제된 효소로 반응시킨 다음 silica gel을 통해 gel filtration을 하여 분리하였으며, 세 번째 방법으로는 발효배양상등액에 에탄올을 첨가하여 생산물을 침전시켜 DFAIII를 분리하였다. 25 g/L의 초기 inulin 농도로부터 각각 1.57, 4.40, 0.34 g/L 의 정제분말이 얻어져 각각 6.3, 17.6, 1.4%의 수율로 회수되었고, 81, 97, 87%의 순도를 각각 나타내었다. 효소반응을 통한 DFAIII 생산 및 회수가 가장 높은 수율과 순도로 회수되었으며, 발효배양을 통한 DFAIII의 생산은 초기기질농도 25 g/L의 50%에 해당하는 DFAIII가 생산되었으나 효소반응에 의한 생산보다는 낮은 수율로 회수되었고 순도는 세 가지 방법 중 가장 낮았으며, 에탄올 침전반응은 가장 낮은 수율을 나타내었다. For the mass production of DFAIII and for the development of techniques of separation and purification of it, the methods of production of DFAIII and its recovery was investigated by fermentation with the strain of Arthrobacter ureafaciens KCTC 3387 and by enzyme reaction. In the first method, DFAIII was produced by fermentation with the strain of Arthrobacter ureafaciens KCTC 3387 and recovered from culture supernatant with silica gel gy filtration, in the second method, it was produced by enzyme reaction and recoverd with the same method of the first, and in third method it was produced by fermentation and recovered by addition of ethanol to the culture supernatnat.Against 25g/L of initial concentration of inulin, 1.57, 4.40, 0.34 g/L of powder of DFAIII was recovered respectively and the rate of recovery was 6.3, 17.6 1.4% and the purity was estimated at 81, 97, 87% respectively. For the production of DFAIII and its recovery, enzyme reaction method was the highest in the rate of recovery and its purity. By fermentation method, DFAIII was produced with 50% fo initial concentration of substrate but th rate of recovery was lower than enzyme reaction method and purity was lowest among the three methods. Ethanol pricipitation method showed the lowest rate of recovery.

세계경제통합으로 인한 새로운 위험관리체제수립의 필요성에 대한 연구

이재찬 한독사회과학회 2009 한독사회과학논총 Vol.19 No.2

세계경제의 통합으로 국가 간 교역에 대한 규제가 점차 사라지면서 세계가 단일시장체재로 전환되고 상품교역이 점차 증가하고 있다. 그러나 미국의 서브프라임모기지 사태로 시작된 미국의 금융위기가 전 세계적으로 급속히 확산되면서 글로벌금융위기상황으로 진전되고 급기야 실물경제의 추락으로 까지 전이되어 글로벌시장에서 상품 제조ㆍ판매활동을 하는 글로벌기업들이 대거 퇴출되는 위기상황을 유발시켰다. 즉, 세계시장의 글로벌화와 더불어 국가 간의 상호의존도가 더욱 증가되면서 글로벌시장의 한 국가에서 발생한 위기상황이 세계시장의 실물경제에 즉각적으로 영향을 주게 된 것이다.이와 같은 글로벌위기의 파급은 글로벌시장의 구조적인 문제에 그 원인이 있다. 첫째로, 과거와는 달리 WTO 및 FTA 등으로 글로벌시장에서 국가 간 상품 및 자본의 자유로운 이동으로 한 지역에서 발생한 위기는 전 세계로 확대/증폭되어 확산되고 모든 글로벌기업은 위기를 피할 수 없이 큰 손실을 입게 된다. 둘째로, 급속한 정보통신기술의 발달로 글로벌상품시장은 “완전경쟁”에 가까운 경쟁시장으로 변하게 되고 기업들은 더 높은 시장점유율을 우선적으로 확보하기 위해 치열한 경쟁을 하게 된다. 그 결과, 생소한 환경의 글로벌시장에서 기업 간의 경쟁이 점차 격해 지고, 기업에게 지속적인 활동에 대한 불안감이 확산되면서 미래에 대한 불확실성이 증가하게 된다. 이와 같은 글로벌시장에 진출하여 제조・판매활동을 해야 하는 기업은 과거 보호무역 하에서와는 전혀 다른 형태의 복합적인 위기상황에 노출되고 있다. 따라서 기업들은 글로벌 환경에 적합한 위험관리(risk management)를 기업의 전략수립에 도입하여 전사적인 위험관리를 실행하여야, 기업이 글로벌위기상황 속에서 위기를 극복하고 기업 가치를 증대시키는데 기여를 할 수 있을 것이다 Mit der Integration der Weltwirtschaft reduzierten sich allmählich die Handelsbarrieren zwischen Ländern und der Weltmarkt wandeltete sich sukzessive sich zu einem freien Einheitsmarkt (e.g. single market). Folglich, hat sich der Warenhandel in der Weltwirtschaft entsprechend vermehrt. Aber die unerwartete Finanzkrise ereignete sich in USA wegen der Subprime-Krise und weitete sich sehr schnell im Globalmarkt aus und stűrzte die Welt in die Welwirtschaftskrise. Viele Unternehmen, die im Globalmarkt tätig waren, haben wegen der wirtschaftlichen Krise den Markt verlassen műssen. Das bedeutet, dass Länder im Globalisierungsprozeβ der Weltwirtschaft wirtschaftlich miteinander eng verbunden sind und von einem Ereignis des Nachbarlandes gleich beeinfluβt werden. Das Vorkommen solcher Weltwirtschaftskrise liegt in der Stuktur des Globalmarktes. Erstens, anders als in der Vergangenheit wird der Transfer der Waren und des Kapitals zwischen Ländern mit der Grűndung der Welthandelsorganization (WTO) und dem Freihandelsabkommen (FTA) zunehmend liberalisiert und vergrőβert. Folglich, ist die Wirtschaft eines einzelnen Landes von der Wirtschaft anderer Länder so abhängig goworden, dass sich eine wirtschaftliche Krise eines Landes im Globalmarkt gleich anderen Ländern űberträgt. Auch erleiden Unternehmen, die im Globalmarkt tätig sind, gleichzeitig einen wirtschaftlichen Schaden. Im Globalisierungsprozeβ kőnnen Unternehmen aufgrund der wirtschaftlichen Verbundenheit solchen wirtschaftlichen Schaden nicht umgehen. Zweitens, hat die drastische Entwicklung der Telekommunikationstechnik den Weltwarenmarkt in einen vollkommenen Markt umgewandelt. Damit werden die Unternehmen, die einer verstärkten Konkurrenzsituation im Markt unterliegen, fűhlen sich unsicher bezűglich zukűnftiger Entwicklung der Marktsituation. Die Entwicklung der Telekommunikationstechnik und der Abbau der Handelbarrieren verursachen im Vergleich mit der Vergangenheit vőllig neuartige, kompliziete und komplexe Krisen. Die Unternehmen kőnnen sich nicht mit dem traditionellen Riskmanagement gegen die komplexen Krisen schűtzen. Deshalb műssen die Unternehmen das an neue Marktsituation angepβte Riskmanagementsystem in die Aufstellung ihrer Unternehmensstrategie einfűhren und anwenden um die Krise zu űberwinden und den hőhren Firmenwert zu erzielen.

Industrial Internet of Things (IIoT) 환경에서 Risk-Level 기반 AoI를 고려한 효율적인 전송 기법

이재찬,정재현,박예본 한국혁신산업학회 2023 혁신산업기술논문지 Vol.1 No.1

不眞正連帶債務者 중 1人이 한 相計의 다른 債務者에 대한 效力

이재찬 민사판례연구회 2012 民事判例硏究 Vol.- No.34

The Supreme Court of Korea ruled in the decision 88daka4994 delivered on March 28, 1989 that a setoff done by an untrue joint and severable debtor does not effect on another debtor. And the Supreme Court has maintained that opinion since the decision above. But there has been a lot of criticism on it. But The Supreme Court changed its opinion in the decision 2008da97218 delivered on September 16, 2010 that a setoff done by an untrue joint and severable debtor also extinguishes another debtor's debt. The author fully supports the new decision of The Supreme Court because of the reasons below. ① A setoff satisfies a credit legally and economically. ② When the absolute effect of a setoff is denied, a creditor comes to get double satisfaction of a credit. This result is against the rule of Korean Civil Law that a creditor cannot get compensation more than damages he suffered. ③ When the absolute effect of a setoff is denied, an untrue joint and severable debtor who did a setoff cannot ask contribution to another debtor. And if an untrue joint and severable debtor who paid actually can ask compensation to another debtor who did a setoff, the another debtor gets damages, or if the debtor who paid actually cannot, the debtor gets damaged. These results are unjustified from the view of economy and fairness. ④ In the case of a setoff contract, it's reasonable that we assume a creditor's intention is to extinguishes his debt to an untrue joint and severable debtor in exchange for his credit to all debtors after consideration of various factors. 대법원은 대법원 1989. 3. 28. 선고 88다카4994 판결 이후 계속하여 부진정연대채무관계에서 채무자 1인이 한 상계는 다른 채무자에게 효력이 미치지 않는다는 입장을 취해왔는데, 이러한 판례의 태도는 많은 비판을 받아왔다. 그런데 대상판결인 대법원 2010. 9. 16. 선고 2008다97218 전원합의체 판결에서 기존의 태도를 바꾸어 부진정연대채무관계에서 채무자 1인이 한 상계는 다른 채무자에게 효력이 미친다고 판시하였다. 대상판결은 다음과 같은 이유로 지극히 타당하다. ① 상계는 경제적으로나 법률적으로나 채권을 현실적으로 만족시키는 사유이다. ② 부진정연대채무에서 상계의 절대적 효력을 부정한다면 필연적으로 채권자는 이중으로 채권의 만족을 받게 된다. 이는 채무불이행이나 불법행위에 기한 손해배상에서 채권자는 자신이 입은 손해 이상의 배상을 받을 수 없다는 우리 법체제의 손해배상에 관한 대원칙에 위배된다. ③ 부진정연대채무관계에서 상계의 절대적 효력을 부정하는 견해에 따르면, 상계를 한 부진정연대채무자는 다른 채무자에 대하여 구상권을 행사할 수 없다. 또한 현실변제를 한 채무자가 상계를 한 채무자에게 구상권을 행사할 수 있다고 하면 상계를 한 채무자가 불이익을 입게 되고, 구상권을 행사할 수 없다고 하면 현실변제를 한 채무자가 불이익을 입게 되는 문제가 있다. 이는 경제적으로나 공평의 관념에서 볼 때 부당하다. ④ 대상판결과 같은 상계계약의 경우에는, 채권자의 의사는 여러 가지 이익을 형량하여 채무자 1인과 상계계약을 통해 부진정연대채무자들 모두에 대한 부진정연대채권을 잃는 대신 자신의 채무자 1인에 대한 반대채무도 소멸시키는 것이라고 봄이 합리적이다.

Optimization of Indole-3-acetic Acid (IAA) Production by Bacillus megaterium BM5

이재찬,황경숙 한국토양비료학회 2016 한국토양비료학회지 Vol.50 No.4

One of the important phytohormones produced by plant growth promoting bacteria is the auxin; indole-3-acetic acid (IAA), with L-tryptophan as the precursor. In this study, we focused on the investigation of optimal conditions for the production of IAA by Bacillus megaterium BM5. We investigated culturing conditions, such as incubation temperature, pH of the culture medium and incubation period, with varying media components such as inoculation volume, tryptophan concentration and carbon and nitrogen source. Besides, optimization study intended for high IAA production was carried out with fermentation parameters such as rpm and aeration. The initial yield of 42 μg IAA ml-1 after 24 hr increased to 85 μg ml-1 when 5% (v/v) of L-tryptophan was used in the culture broth. The maximum yield of 320 μg IAA ml-1 was observed in trypticase soy broth (TSB) supplemented with starch and soybean meal as C and N sources with a C/N ratio of 3:1 (v/v) at 30°C, pH 8.0 for 48 hrs with 1.0 vvm and 250 rpm in 5 L working volume using 10 L scale fermenter. The bacterial auxin extracted from the culture broth was confirmed by thin layer chromatography and high-performance liquid chromatography and effect on plant growth was confirmed by root elongation test.

해사법원 설치에 관한 연구

이재찬 사법정책연구원 2021 현안보고서 Vol.2021 No.1

Sulfa 제 투여가 백서 영양에 미치는 영향 : 특히 체성분 변동에 대하여

이재찬 생화학분자생물학회 1973 BMB Reports Vol.3 No.1