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Halothane 마취후 발생한 간괴사 13예의 임상적 고찰
이용구(Y K Lee),김학철(H C Kim),조원섭(W S Cho),조정구(C G Cho) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A There were many controversies concerning halothane-induced hepatitis, but a few cases suggest there was clinical, historical, biochemical, immunologial and epidermiological evidence to support theory of halothane induced hepatitis. We described 13 cases who had otherwise unexplained hepatitis after halothane anesthesia. The clinical features and complications were similar to those of any other severe hepatitis, but some differences were noticed. We obtained the results as followings; 1) The most common clinical symptom was high fever, which was noticed in 12 of the 13 cases, and it occurred between the 4th to 16th postoperative day, and its duration was variable, but ranging from 3 to 10 days. 2) The other clinical symptoms were non-specific G-I symptoms, myalgia, headache, easy fatigue and jaundice. And constitiutional prodromal symptoms were developed during or after the post-febrile period, but gradually subsided after the onset of clinical jaundice. 3) Abnormal laboratory findings, espicially AST and ALT, showed a variable increase during the onset of the febrile period or at its conclusion. The peak levels of serum aminotransferases were noticed at the end of febrile period, or the post-febrile period and they gradually normalized after 3 to 6 weeks in the most of the cases. 4) The relative frequency of the unexplained hepatitis was observed as follows; in the 13 cases; above the umbilicus of the operaive site (9), hypotension during operation (8), previous history of surgery under general anesthesia (4), obesity (5). And the fatality rate was 15.1% (2), these two cases showed a prolongation of the prothrombin time 8 seconds over the normal control time.
김기윤(G.Y. Kim),김보현(B.H. Kim),김윤년(Y.N. Kim),이용구(Y.G. Lee),허윤석(Y.S.Heo) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Aortic dissection is the most dangerousheart disease. It can cause aortic rupture in any time with treatment or without treatment. Thus patients must manage therisk factors. To control the factor like blood pressure, we need to set a threshold value for the safe zone for each patient.This important threshold can be obtained from analysis of blood flow. In this study, the clinical data was used to obtainthe 3D model of aortic dissection. The fluid flow simulation was done by using comsol multiphysics. We have preformed analysisin laminar fluid condition with inlet pressure. Velocity was analyzed along the 3d model. As we have expected, the velocitywas increased in the point of dissection was occurred. However, the increment of velocity was very large in the criticalarea.
김민영(M.Y. Kim),이용구(Y.G Lee),김윤년(Y.N. Kim),남창욱(C.W Nam),허윤석(Y.S.Heo) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Aortic dissection is a medical emergency situation requiring quick and proper treatments, otherwise patient can suddenly lead to death as a result of rupture of the aorta. The rupture can be triggered by many factors such as blood pressure, velocity, viscosity etc. and it is critical for patients to manage the internal and external factors acting on the blood vessels before the rupture begins. To control the factor like blood pressure, we need to set a threshold value for the safe zone for each patient to provide proper treatment guidelines. This important threshold can be obtained from the analysis of blood flow in the 3D model of aortic dissection. In this study, we analyzed CT images obtained from three patients who had three different type of the aortic dissection, respectively. The fluid flow simulations were done by using COMSOL Multiphysics. The results from the computational simulation are able to explain the blood flow characteristics and are well accordance with the expectation from the patient’s condition and types of aortic dissection.
이임식,이용구,전병세 慶南大學校 附設 工業技術硏究所 1994 硏究論文集 Vol.12 No.-
α-alumina와 Mg acetate[Mg(C₂H₃O₂)₂+4H₂O] 및 Na₂CO₃를 사용하여 in-situ 반응소결에 의해 침상의 ??-alumina를α-alumina 기지상에 균일하게 분포시킴으로써 이론밀도까지 소결이 가능하였고, 또한 고강도, 고인성의 알루미나 세라믹스를 만들 수 있었다. ??-alumina에 의한 알루미나의 강화기구는 균열굴절기구 뿐만 아니라 상경계와 입계 미끄러짐의 방해에 의해서α-alumina 기지상의 입자성장이 억제되었기 때문이라고 판단된다. Alumina ceramics were reinforced by in-situ formation of needle-shaped ??-alumina in α-alumina matrix. The tentative answer to the question why α/??-alumina composite is stronger than α-alumina can be explained by two aspect. One point is that, when ??-alumina is formed in α-alumina matrix, grain growth of α-alumina is hampered because needle-shaped ??-alumina can inhibit the grain boundary sliding of α-alumina during sintering or ??-alumina acts as phase boundary which makes the diffusion path longer. Secondly, when crack tip meets the ??-alumina, it deflects and has a longer crack path. Thus, the introduction of needle-shaped ??-alumina in α-alumina matrix through reaction sintering makes the alumina ceramics stronger and tougher.