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한국산 생약제로부터 항암성분의 추출 및 그의 항암성활성 측정에 관한 연구
황우익,차승만,이세영 ( Woo Ik Hwang,S . Cha,Se Young Lee ) 생화학분자생물학회 1980 BMB Reports Vol.13 No.1
The number of patient with tumor is rapidly getting increase year by year, but antitumor agent has not been much developed. Therefore the studies on the development of anticancer drug is one of the most important task in the medical field. The Chinese medicinal botany in Korea have been well developed since Korea Dynasty and $quot;Dong-Eui-Bo-Gam$quot;, famous classic handbook of Korean traditional medicine, written by Huh Jun and published in 1913. In addition some medicinal plants have been used for the treatment of tumor patient. Two hundreds and nintythree kinds of medicinal herbs, which have been used in Korea, are classified according to the pharmacological effects by Hong and 10 herbs of those were to be used as anticancer agents by Cha. In this study I have attemped to obtain basic materials for the development of anticancer drugs from Korean medicinal herbs. The experimental results obtained are summarized as follows; 1. Each water-extract of Scirpus maritimus, Foeniculum vulgare, Curcuma zedoaria, Raphanus sativus and Rheum undulatum inhibited the growth of leukemia cell and the inhibitory activity was parallel to the concentration of the extract. 2. Water-extracts of Euphorbia kansui, Croton tiglium, Galarhaeus pekinensis and Daphne pseudogenkwa also inhibited the cell growth. However the effect was not proportional to the concentration, and the inhibitory effect appeared only at above of a given concentration. 3. The inhibitory effects of alcohol extracts of Scirpus maritimus, Foeniculum vulgare, Curuma zedoria and Raphanus sativus were not significant. 4. Alcohol extracts of Euphorbia kansui, Croton tiglium, Galarhaeus pekinensis and Daphne pseudogenkwa showed the similar tendency with (effect of the waterextracts. 5. No inhibitory effect was observed in petroleum ether extracts of all herbs (except Euphorbia kansui). From the above results it was found that the effective antitumor component is more extractable with water than organic solvents, and the water-soluble components of Scirpus maritimus, Foeniculum vulgare, Curcuma zedoaria and Raphanus Sativus are heat-stable and less toxic. Hence it is conclusive from the present study that further experimental studies on the anticancer effect of the water-soluble components of thE: above 4 kinds of herbs are promising.
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한국산 생약제로부터 항암성분의 추출 및 그의 항암성활성 측정에 관한 연구
황우익,차승만,이세영,Hwang, Woo-Ik,Cha, S.,Lee, Se-Young 생화학분자생물학회 1980 한국생화학회지 Vol.13 No.1
우리나라 한방에서 암치료제로 가장 많이 처방되고 있는 10종의 생약제 즉 삼능, 회향, 아술, 나복자, 대황, 도인 감수 파두 대극 및 원화등을 물, 알콜 및 석유에텔로 각각 추출하여 암세포의 일종인 L5178Y cell을 대상으로 in vitro 에서 각추출물의 항암활성을 측정 하였다. 이결과 수용성 추출물에서 삼능, 회향, 아술, 나복자 및 대황 등의 것은 첨가량의 증가에 비례하여 암세포의 증식이 점차적으로 억제 되었으나 감수 파두 대극 및 원화 등의 것은 첨가량의 농도에 비례하지 않고 어느 농도 이상에서는 증식이 크게 억제되고 그농도 이하에서는 억제효과가 없었다. 알콜추출물에서 상능, 회향, 아술 및 나복자 등의 것은 암세포 증식억제 효과가 없었으나 대황 감수 파두 대극 및 원화등의 것은 수용성 추출물의 활성과 같은 경향을 보였다. 석유에텔 추출물에서는 각생약제 모두 항암활성이 무시할 정도로 미약 하였다. 이상의 결과로 보아 삼능 회향 아술 및 나복자 등의 수용성 추출물중에 열에도 안정하고 비교적 독성이 적은 항암성분이 존재할 가능성이 있을 것으로 예상 된다. The number of patient with tumor is rapidly getting increase year by year, but antitumor agent has not been much developed. Therefore the studies on the development of anticancer drug is one of the most important task in the medical field. The chinese medicinal botany in Korea have been well developed since Korea Dynasty and "Dong-Eui-Bo-Gam", famous classic handbook of Korean traditional medicine, written by Huh Jun and published in 1913. In addition some medicinal plants have been used for the treatment of tumor patient. Two hundreds and nintythree kinds of medicinal herbs, which have been used in Korea, are classified according to the pharmacological effects by Hong and 10 herbs of those were to be used as anticancer agents by Cha. In this study I have attemped to obtain basic materials for the development of anticancer drugs from Korean medicinal herbs. The experimental results obtained are summarized as follows; 1. Each water-extract of Scirpus maritimus, Foeniculum vulgare, Curcuma zedoaria, Raphanus sativus and Rheum undulatum inhibited the growth of leukemia cell and the inhibitory activity was parallel to the concentration of the extract. 2. Water-extracts of Euphorbia kansui, Croton tiglium, Galarhaeus pekinensis and Daphne pseudogenkwa also inhibited the cell growth. However the effect was not proportional to the concentration, and the inhibitory effect appeared only at above of a given concentration. 3. The inhibitory effects of alcohol extracts of Scirpus maritimus, Foeniculum vulgare, Curuma zedoria and Raphanus sativus were not significant. 4. Alcohol extracts of Euphorbia kansui, Croton tiglium, Galarhaeus pekinensis and Daphne pseudogenkwa showed the similar tendency with effect of the water-extracts. 5. No inhibitory effect was observed in petroleum ether extracts of all herbs (except Euphorbia kansui). From the above results it was found that the effective antitumor component is more extractable with water than organic solvents, and the water-soluble components of Scirpus maritimus, Foeniculum vulgare, Curcuma zedoaria and Raphanus Sativus are heat-stable and less toxic. Hence it is conclusive from the present study that further experimental studies on the anticancer effect of the water-soluble components of the above 4 kinds of herbs are promising.
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