산후우울증 환자에서 혈중 Nitric Oxide Metabolites의 혈장 농도의 변화

이분희,김계현,신영철,김정범,김용구,Lee, Bun-Hee,Kim, Kye Hyun,Shin, Young Chul,Kim, Jung Bum,Kim, Yong-Ku 대한생물정신의학회 2006 생물정신의학 Vol.13 No.1

Background : Some reports have suggested that decreased nitric oxide metabolites($NO_x$) and activity of nitric oxide synthase could be related to the pathophysiology of depression. We evaluated plasma levels of $NO_x$ in pregnant women with and without postpartum depression at prenatal and postnatal period. Methods : The plasma concentrations of $NO_x$ were measured in 104 pregnant women in the third trimester and at 6 weeks postpartum and in 64 normal controls. The severity of depression and anxiety was measured with the Edinburgh Postnatal Depression Scale(EPDS), Beck Depression Inventory(BDI), and Beck Anxiety Scale(BAI). Results : Plasma $NO_x$ levels at 6 weeks postpartum were significantly lower in cases of postpartum major depression(EDPS scores${\geq}$13 points) than in cases without depression(EDPS scores${\leq}$9 points). Plasma $NO_x$ levels had significantly negative correlation with EPDS scores at 6 weeks postpartum. Conclusion : We demonstrate that decreased plasma $NO_x$ is associated with postpartum depression. Further studies are required to determine whether individual serum concentration of plasma $NO_x$ alone could predict maternal depression.

리스페리돈을 복용한 여성 환자에서 유발된 무월경의 치료

이분희,김용구,한창수,고영훈,Lee, Bun-Hee,Kim, Yong-Ku,Han, Chang-Su,Ko, Young-Hoon 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2

Objective:To find out the optimal assessment that can relieve amenorrhea associated with risperidone. Methods:Sixteen female outpatients who have taken risperidone for more than 3 months reported voluntarily amenorrhea during Nov 2001 to May 2002. Since the reports of the amenorrhea, the resolution of amenorrhea has been prospectively followed during the next six months. The dosage of risperidone was reduced or discontinued in nine of sixteen patients, while risperidone was switched to olanzapine or quetiapine in other 7 patients according to the clinician's decision. Results:Fourteen of 16 patients showed higher levels of prolactin than normal level. Five patients of the risperidone-reduction group recovered from the amenorrhea while all subjects of the drug-switch group recovered. The resolved patients of the former group recovered from amenorrhea in the dosage below 3mg per day of risperidone. Two patients of the risperidone-reduction group were dropped out during the reduction. Conclusion:These findings suggest that risperidone-induced amenorrhea may be alleviated by reducing dosage to less 3mg per day(including discontinuation) or by switching to other antipsychotic drugs. Whether we would choose which method depends on patient's clinical status, diagnosis, and dose of medication and so on.

양양 낙산사 원통보전 건칠관음보살상 연구

이분희 한국불교미술사학회 2023 강좌미술사 Vol.61 No.-

The Statue of Avalokitesvara Bodhisattva in Naksansa Temple had been enshrined in the main dharma hall of the temple ever since it was founded by the great Silla monk Uisang. However, the statue disappeared from the temple and was not retrieved until recently, when it was discovered at the nearby Yeonghyeolsa Temple, which is closely related with the worship of Avalokitesvara. As one of the dry-lacquered Buddhist statues produced between late Goryeo and early Joseon, the Statue of Avalokitesvara Bodhisattva in Naksansa Temple features a bejeweled headdress, lavishly decorated garments, elaborate finishing touches with a gold-painted interior, and the use of outstanding carving techniques. These aesthetic elements were much cherished by the royal family and nobility of both Goryeo and Joseon, suggesting that the statue was patronized by the royal family. The Statue of Avalokitesvara Bodhisattva is also marked by an imposing, proportional body sitting in the lotus position, suggesting that it was created as the principal Buddhist figure to be enshrined in Wontongjeon Hall. The Statue of Avalokitesvara Bodhisattva enshrined in Naksansa Temple is comparable in terms of it sculptural style with the gilt-bronze statue of Avalokitesvara and Ksitigarbhah enshrined in Daejeokgwangjeon Hall of Haeinsa Temple. The fact that the latter two were produced in 1351 suggests that the statue of Avalokitesvara might date back to the late fourteenth century. The elegant, well-defined face, well-built body with a voluminous chest, waist-band with a delightfully simple knot, and Ω-shaped fold in the robe on the left arm are all features that can be seen in statues of bodhisattvas dating back to the late Goryeo and early Joseon periods. Furthermore, the pedestal covered with the bodhisattva’s lower garment is a characteristic feature of the Buddhist statues made during late Goryeo under the influence of Buddhist sculpture of the Chinese Yuan dynasty.

奉恩寺 三世佛像의 硏究

이분희 한국불교문화학회 2004 불교문화연구 Vol.3 No.-

정신분열병 환자에서 자살시도, 우울증상 및 혈장 콜레스테롤 농도와의 관련성 /

이분희,김용구 대한정신분열병학회 2006 대한조현병학회지 Vol.9 No.1

불순도 기반 딥러닝 CNN 모델 최적 가지치기 레이어 검출 방법

박규도(Gyu-Do Park),김근수(Geun-Su Kim),강수혁(Soo-Hyeok Kang) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

金山寺 五層石塔 舍利莊嚴具 硏究

이분희 중앙승가대학교 불교학연구원 2016 불교와 사회 Vol.8 No.-

금산사 오층석탑을 해체하여 수리할 때 탑안에서 <母嶽山金山寺五層石塔重創記>와 각종의 사리구가 발견되었다. 발견된 중창기에는 금산사 오층석탑의 조성시기와 중창불사 현황과 관련 인물 등을 소상하게 알려주는 내용이 실려 있다. 이는 단절된 조선 전기 금산사에 대한 역사를 이어줄 수 있는 중요한 자료이다. 뿐만아니라 동제사리합과 작은 합 2점, 청동오층탑과 엽전 7점, 그리고 불상 8구와 동자상 1구 등 일체의 금산사 오층석탑 사리장엄구는 조선 초 사리장엄구의 구성과 특징을 이해할 수 있는 미술사에서 매우 중요한 자료이다. 금산사 오층석탑 중창기에는 금산사 오층석탑의 해체과정, 사리장엄구의 발견, 그리고 탑 안에 다시 사리장엄구를 봉안하는 과정까지 묘사되어 있다. 뿐만아니라 덕원군을 대공덕주로 한 왕실의 지원에 힘입어, 이 지역의 지방관료, 그리고 스님들이 대거 참여하였음을 알 수 있다. 탑에 봉안된 사리장엄구는 탑의 조성시와 중창당시에 매납된 것으로 나눌 수 있는데, 각 시기별 특징을 담고 있다. 특히, 탑내 봉안된 불상들은 1492년 탑을 중창할 당시 조성하여 스님들이 모셨던 원불로, 16세기 전후의 불교조각사 양식을 이해하는데 단서가 되는 불상들이다. 이렇게 불상을 탑에 봉안하는 것과 봉안한 불상에 불복장과 사리를 넣는 사리장엄구의 독특한 특징은 매우 흥미롭다. 금산사 탑에 불상을 봉안하였던 이유는 불상 신앙이 고조되면서, 개인의 소원을 비는 구복적 원불신앙의 유행에 기인한 듯 하다. 즉, 법당에 불상을 봉안하듯이 탑에 불상을 봉안하였던 당시 신앙경향을 살펴볼 수 있다. In dismantling and repairing Geumsansa Temple’s Five-story Stone Pagoda, discovered from within the pagoda were sarira receptacles and Moaksan geumsansa ocheungseoktap jungchanggi (Construction Records on Moaksan Geumsansa Temple’s Five-story Stone Pagoda). The records give a detailed description of Geumsansa Temple’s Fivestory Stone Pagoda construction time, reconstruction situation, and related personnel, making them an important material in learning about the history of Geumsansa Temple in the first half period of the Joseon. Likewise, items contained in the Five-story Stone Pagoda Sarira Reliquaries -- such as a copper sarira bowl and two small bowls, a Five-story Bronze Pagoda and seven coins, eight Buddha images, and one cherub figure -- are very important materials in understanding the composition and characteristics of early-time Joseon Sarira Reliquaries in the history of arts. The reconstruction records describe the process of demolishing the pagoda, the discovery of Sarira Reliquaries, and the process of enshrining Sarira Reliquaries in the pagoda. It was also revealed that, with the support of the royal household with Prince Deogwongun as the biggest sponsor, a large number of the region’s local officials and monks participated in Buddhist affairs. The local governor, too, encouraged the Hyangdo community to allow many worshippers to participate in Buddhist affairs. The Sarira Reliquaries enshrined inside the pagoda were provided during the construction and reconstruction of the pagoda and are characterized according to the times. In particular, Buddhas enshrined inside the pagoda were created in 1492 when the pagoda was constructed and were served by monks. They are very important in understanding the Buddhist sculpture styles around the 16th century. It is very interesting to enshrine Buddhas inside the pagoda and to install Sarira Reliquaries containing statues inside which sariras are put, without using other apparatuses. Buddhas were enshrined in the Geumsansa Temple Pagoda presumably because, with devotion to the Buddha image being heightened, individuals’ faith of seeking blessings was popular. In other words, as Buddha images were enshrined in worship halls, they were also enshrined in pagodas, a new faith trend at the time.

조각승 승일파 불상조각의 연구

이분희 한국불교미술사학회 2006 강좌미술사 Vol.26 No.2

항정신병 약물에 의한 혈중 프로락틴 변화와 도파민 전달체 유전자 다형성

이분희,김용구,서광윤,Lee, Bun-Hee,Kim, Yong-Ku,Suh, Kwang-Yoon 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2

Object:We investigated the relationship between prolactin response to antipsychotics and clinical courses of psychotic symptoms and DAT gene polymorphisms. Method:Twenty-four acute psychotic inpatients completed the 12-week trial of risperidone. Serum prolactin, BPRS, ESRS and hyperprolactinemia-related symptoms were measured at baseline, 2, 4, 8 and 12 weeks after medication. The DAT gene polymorphisms were analyzed. Results:The serum prolactin was significantly increased over time. According to the prolactin level at 2-week, the subjects were divided into the severe group(serum prolactin>60ng/mL, N=15) and the mild group (serum prolactin<60ng/mL, N=9). The prolactin levels of the mild group didn't increase beyond 60ng/mL throughout 12 weeks. Severe group had slower decrement of BPRS scores than those of mild group. Six females in severe group complained of irregular menstruations, but no female in mild group. Most patients had 10 allele of DAT gene. Conclusion:This study suggests that the magnitude of prolactin elevation at the 2-week of risperidone medication is correlated with severity of hyperprolactinemia throughout treatments. Our results did not show the relationship between prolactin responses and DAT gene polymorphisms.

정신과에 의뢰된 환자 중 수면장애에 대한 ICSD와 DSM-Ⅳ 진단 비교

이분희,김린,서광윤,Lee, Bun-Hee,Kim, Leen,Suh, Kwang-Yoon 대한수면의학회 2001 수면·정신생리 Vol.8 No.1

Background: Sleep disorders are prevalent in the general population and in medical practice. Three diagnostic classifications for sleep disorders have been developed recently: The International Classification of Sleep Disorders (ICSD), The Diagnostic and Statistical Manual, 4th edition (DSM-IV) and The International Classification of Diseases, 10th edition (ICD-10). Few data have yet been published regarding how the diagnostic systems are related to each other. To address these issues, we evaluated the frequency of sleep disorder diagnoses by DSM-IV and ICSD and compared the DSM-IV with the ICSD diagnoses. Method: Two interviewers assessed 284 inpatients who had been referred for sleep problems in general units of Anam Hospital, holding an unstructured clinical interview with each patient and assigning clinical diagnoses using ICSD and DSM-IV classifications. Results: The most frequent DSM-IV primary diagnoses were "insomnia related to another mental disorder (61.1% of cases)" and "delirium due to general medical condition (26.8%)". "Sleep disorder associated with neurologic disorder (38.4% of cases)" was the most frequent ICSD primary diagnosis, followed by "sleep disorder associated with mental disorder (33.1%)". In comparing the DSM-IV diagnoses with the ICSD diagnoses, sleep disorder unrelated with general medical condition or another mental disorder in DSM-IV categories corresponded with these in ICSD categories. But DSM-IV "primary insomnia" fell into two major categories of ICSD, "psychophysiologic insomni" and "inadequate sleep hygiene". Of 269 subjects, 62 diagnosed with DSM-IV sleep disorder related to general medical condition or another mental disorder disagreed with ICSD diagnoses, which were sleep disorders not associated with general medical condition or mental disorder, i. e., "inadequate sleep hygiene", "environmental sleep disorder", "adjustment sleep disorder" and "insufficient sleep disorder". Conclusion: In this study, we found not only a similar pattern between DSM-IV and ICSD diagnoses but also disagreements, which should not be overlooked by clinicians and resulted from various degrees of understanding of the pathophysiology of the sleep disorders among clinicians. Non-diagnosis or mis-diagnosis leas to inappropriate treatment, therefore the clinicians' understanding of the classification and pathophysiology of sleep disorders is important. 목 적 : 최근 수면장애에 대한 3가지 진단 분류 체계가 발달하였다. 즉 국제 수면장애 분류(the International Classification of Sleep Disorder, ICSD), 정신장애의 진단 및 통계 편람 제 4 판(the Diagnostic and Statistical Manual, 4th edition, DSM-IV) 그리고 국제 질병 분류 제 10 판(the International Classification of Diseases, 10th edition, ICD-10)이다. 국내에는 이들 진단 체계간의 비교에 대한 자료가 거의 없다. 본 저자들은 수면 문제로 정신과에 의뢰된 환자를 DSM-IV와 ICSD에 따라 진단하고 이를 비교하여 그 차이를 비교하고자 하였다. 방 법 : 고려대학부속 안암병원에 입원 환자 중 수면장애로 정신과에 의뢰된 284명의 환자를 대상으로 ICSD를 숙수면장애에 대한 ICSD와 DSM-IV 진단 비교 44지하지 않은 정신과 전공의와 ICSD를 숙지한 정신과 전공의가 비구조화된 면담을 시행하고, DSM-IV와 ICSD의 진단 기준에 따라 임상적 진단을 하여 그 차이를 비교하였다. 결 과 : DSM-IV 진단 분류에는 "기타 정신장애 관련 불면증"(전체의 61.1%)과 "일반적인 의학적 상태로 인한 섬망"(26.8%)이 빈도가 가장 높았다. ICSD에서는 "신경과적 장애가 동반된 수면장애" (38.4%)와 "정신과적 장애가 동반된 수면장애" (33.1%)의 빈도가 가장 높았다. DSM-IV와 ICSD의 비교에서, DSM-IV에서 신체적 질환이나 정신과적 질환과 무관한 수면장애로 진단된 환자군은 대부분 ICSD와 일치하였고, 이들 중 DSM-IV의 "일차적 불면증"은 ICSD의 "정신생리적 불면증"과 "부적수면위생"으로 구분되었다. DSM-IV에서 신체적 질환이나 정신과적 질환에 의한 수면장애를 가진 269명 중 62명(23%)이 ICSD와 불일치하였고 이들 중 대부분이 ICSD에서 신체적 질환이나 정신과적 질환과 무관한 수면장애인 "부적수면위생", "환경성 수면장애", "적응성 수면장애" 그리고 "수면결핍장애" 등이었다. 결 론 : 본 연구에서 DSM-IV와 ICSD의 진단 체계가 많은 부분 일치하였으나, 간과할 수 없는 차이를 가지고 있음을 확인하였다. 이 차이는 수면장애에 대한 임상의의 태도를 반영한다. 즉, 수면장애에 대한 개념화와 원인에 대한 임상의의 이해 정도에 따라, 수면장애를 진단하지 못하거나 적절한 치료를 할 수 없다. 따라서 본 연구에서 나타난 DSM-IV와 ICSD에 대한 임상의의 이해 정도는 중요하다고 할 수 있다.