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Infliximab 치료 후 호전된 난치성 포도막염을 동반한 베체트병
최정우 ( Jeong Woo Choi ),최용준 ( Yong Joon Choi ),예영민 ( Young Min Ye ),김상하 ( Sang Ha Kim ),남동호 ( Dong Ho Nam ),박해심 ( Hae Sim Park ),이마빈 ( Ma Bin Lee ),유호민 ( Ho Min Yoo ),서창희 ( Chang Hee Suh ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.4
Behcet`s disease is a multisystemic, chronic relapsing inflammatory disease characterized by vasculitides, mucocutaneous lesions, thrombophlebitis, arthritis. Among them, the ocular involvement is usual (50∼70%) and the most serious morbidity is blindness (20∼25% of those of affected). Immunosuppressive treatment is currently the main therapy in chronic relapsing uveitis, but many patients experience recurrent sight-threatening uveitis. T lymphocytes play an important role in the pathogenesis of uveitis by releasing cytokines such as tumor necrosis factor (TNF) α. There are some reports that the anti-TNFα treatment is effective in refractory Behcet`s uveitis, but it has not been reported in Korea. We report a case of refractory uveitis in Behcet`s disease which is improved after anti-TNFα therapy.