성인 집먼지진드기 알레르기 환자에서 특이 IgE 결합 성분 항원 비교

진현정 ( Hyun Jung Jin ),윤문경 ( Moon-gyung Yoon ),남영희 ( Young-hee Nam ),안준홍 ( June Hong Ahn ),박해심 ( Hae-sim Park ),정진홍 ( Jin Hong Chung ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.3

Purpose: This study investigated the differences in the profile of IgE-binding components between Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farina (Df) in respiratory allergic patients sensitized to Dp/Df. Methods: Eighteen patients with respiratory allergic diseases having higher levels of serum specific IgE to Df compared to those to Dp (>twice) were enrolled. IgE-immunoblot analysis using Dp and Df extracts were used to compare the IgE binding components. Study subjects were classified into 2 groups according to the results of IgE-immunoblot analysis: 6 subjects having IgE-binding components to group 1 and 2 allergens (group B) and 12 subjects not having them (group A). Results: Group A subjects were older (47.92±8.51 vs. 35.50±11.10, P=0.039) and males were dominant (75% vs. 0% P=0.009). IgE-immunoblot analysis demonstrated that all the group B subjects had IgE bindings to 2 major components, 14 and 25 kDa, while group A subjects had IgE bindings to high-molecular weight components ranging from 60.98 kDa. The enzyme-linked immunosorbent assay inhibition test showed a significant inhibition with additions of Df, not with Dp in group B subjects. Serum specific IgE levels to Dp and Df were significantly higher in group B than in group A, while its ratio (Df to Dp) was significantly higher in group A. No differences were noted in clinical parameters, total IgE, or eosinophil cationic protein levels. Conclusion: Heterogeneity of IgE binding patterns to Dp and Df extracts was noted according to the ratio of serum specific IgE (Df/Dp). (Allergy Asthma Respir Dis 2016;4:199-204)

돼지풀과 쑥 화분의 주 알레르겐에 대한 IgE 결합 성분의 규명

윤문경 ( Moon Gyung Yoon ),김미애 ( Mi Ae Kim ),진현정 ( Hyun Jung Jin ),신유섭 ( Yoo Seob Shin ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.5

Purpose: Ragweed and mugwort pollens are the major weed allergens that cause pollinosis in Korea. The IgE-binding components to these 2 pollens and their cross-reactivity have not been reported in Korea, while several reports had been made in Western countries. We investigated IgE-binding components to ragweed and mugwort pollens and their allergenic relationship in patients sensitive to the 2 pollens. Methods: We enrolled 33 allergic rhinitis patients with typical seasonal pollinosis symptoms in autumn and elevated serum specific IgE levels to ragweed and/or mugwort pollens (>10 kU/L by ImmunoCAP). The protein bands of the 2 pollen extracts were determined using sodium dodecyl sulphate-polyacrylamide gel electrophoresis, and IgE immunoblot analysis was performed to determine the IgE-binding components of each pollen extract. Enzyme-linked immunosorbent assay (ELISA) inhibition and immunoblot inhibition tests were performed to evaluate the cross-reactivity between ragweed and mugwort pollen extracts. Results: Eight IgE-binding components (9, 10, 11, 12, 27, 30, 38, and 80 kDa) were found in ragweed pollen extracts, of which 4 (38, 11, 27, and 80 kDa) were major IgE-binding components. Eight IgE-binding components (10, 14, 16, 20-24, 26-30, 42, 60-66, and 80-90 kDa) were found in mugwort pollen extracts, of which 2 components (26-30 and 20-24 kDa) were major IgE-binding components. No significant inhibitions were noted between ragweed and mugwort pollen extracts by the ELISA inhibition test. No significant changes were noted in IgE immunoblot inhibition analysis. Conclusion: We identified 4 major IgE-binding components (38, 11, 35, 27, and 80 kDa) in ragweed pollens and 2 major IgE-binding components (26-30 and 20-24 kDa) in mugwort pollens. No cross-reactivity was found between ragweed and mugwort pollens.(Allergy Asthma Respir Dis 2014;2:337-343)

자작나무와 오리나무 화분의 주 알레르겐에 대한 immunoglobulin E 결합 성분의 규명

윤문경 ( Moon Gyung Yoon ),김미애 ( Mi Ae Kim ),진현정 ( Hyun Jung Jin ),신유섭 ( Yoo Seob Shin ),박해심 ( Hae Sim Park ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3

Purpose: Pollinosis is one of the major allergic diseases caused by airborne pollens. Alder and birch pollens are the major sensitizing tree pollens in this country. The immunoglobulin E (IgE) reactivity to each pollen allergen is known to be variable according to the region. We determined the major IgE binding components of these tree pollens in sera of adult patients with allergic rhinitis. Methods: Allergic rhinitis patients, of whom specific IgE level to birch and/or alder pollens (>10 kU/L by ImmunoCAP) were included. The protein bands of two pollen extracts were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, and their IgE-binding components were identified by IgE immunoblot analysis. The binding specificity and cross-reactivity between two pollens were evaluated by IgE enzyme linked immunosorbent assay (ELISA) inhibition test. Results: Six IgE binding components were found in birch pollens in which two (14 kDa and 17 kDa) were major components. Two IgE binding components were found in alder pollens in which the 17 kDa was a major component. The IgE binding component to the major allergen component of 17 kDa was observed in 90.3% of the study subjects sensitive to alder pollens and 72.7% of them sensitive to birch pollens. The ELISA inhibition tests showed significant inhibitions with additions of birch/alder pollen extracts. Conclusion: We identified two major IgE binding components (17 kDa and 14 kDa) from birch pollens and one component (17 kDa) from alder pollens. Significant cross reactivity was noted between these two pollens. (Allergy Asthma Respir Dis 2013;1:216-220)

자작나무와 오리나무 화분의 주 알레르겐에 대한 immunoglobulin E 결합 성분의 규명

윤문경 ( Moon Gyung Yoon ),김미애 ( Mi Ae Kim ),진현정 ( Hyun Jung Jin ),신유섭 ( Yoo Seob Shin ),박해심 ( Hae Sim Park ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: Pollinosis is one of the major allergic diseases caused by airborne pollens. Alder and birch pollens are the major sensitizing tree pollens in this country. The immunoglobulin E (IgE) reactivity to each pollen allergen is known to be variable according to the region. We determined the major IgE binding components of these tree pollens in sera of adult patients with allergic rhinitis. Methods: Allergic rhinitis patients, of whom specific IgE level to birch and/or alder pollens (>10 kU/L by ImmunoCAP) were included. The protein bands of two pollen extracts were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, and their IgE-binding components were identified by IgE immunoblot analysis. The binding specificity and cross-reactivity between two pollens were evaluated by IgE enzyme linked immunosorbent assay (ELISA) inhibition test. Results: Six IgE binding components were found in birch pollens in which two (14 kDa and 17 kDa) were major components. Two IgE binding components were found in alder pollens in which the 17 kDa was a major component. The IgE binding component to the major allergen component of 17 kDa was observed in 90.3% of the study subjects sensitive to alder pollens and 72.7% of them sensitive to birch pollens. The ELISA inhibition tests showed significant inhibitions with additions of birch/alder pollen extracts. Conclusion: We identified two major IgE binding components (17 kDa and 14 kDa) from birch pollens and one component (17 kDa) from alder pollens. Significant cross reactivity was noted between these two pollens. (Allergy Asthma Respir Dis 2013;1:216-220)

문화재 (pagoda) 복원을 위한 GAN 알고리즘 연구

윤진현(Jin-Hyun Yoon),이병권(Byong-Kwon Lee),김병완(Byung-Wan Kim) 한국컴퓨터정보학회 2021 韓國컴퓨터情報學會論文誌 Vol.26 No.1

오늘날 문화재 복원은, 기존 자료와 전문가에 의존하는 것과 더불어 최신 IT 기술을 적용하여 복원하고 있다. 하지만 새로운 자료가 나와서 기존 복원이 틀리게 되는 경우, 복원하는데 너무 오랜 시간이 걸릴 때도 있다. 그리고 예상과 다른 결과가 나올 가능성도 있다. 이에 우리는 중요 문화재의 복원을 인공지능을 이용하여 빠르게 복원을 해 보고자 한다. 최근에 Generative Adversarial Networks(GANs) 알고리즘에서 DcGAN[2] 알고리즘이 나오면서 이미지 생성, 복원 분야가 지속해서 발전하고 있다. 이에 본 연구에서는 다양한 GAN 알고리즘을 문화재 복원에 GAN 알고리즘을 적용해 보았다. DcGAN과 StyleGAN을 적용하였으며, 유의미한 결과를 얻었다. GAN 알고리즘 중 DCGAN과 Style GAN 알고리즘을 실험한 결과 DCGAN 알고리즘은 학습이 진행되었으며, 낮은 해상도로 탑 이미지가 생성되는 것을 확인했다. 그리고 Style GAN 알고리즘에서도 역시 학습이 진행 되었으며, 탑 이미지가 생성되었다. 결론적으로 GAN 알고리즘을 사용하여 높은 해상도의 탑 이미지를 구할 수 있게 되었다. Today, the restoration of cultural properties is done by applying the latest IT technology from relying on existing data and experts. However, there are cases where new data are released and the original restoration is incorrect. Also, sometimes it takes too long to restore. And there is a possibility that the results will be different than expected. Therefore, we aim to quickly restore cultural properties using DeepLearning. Recently, so the algorithm DcGAN made in GANs algorithm, and image creation, restoring sectors are constantly evolving. We try to find the optimal GAN algorithm for the restoration of cultural properties among various GAN algorithms. Because the GAN algorithm is used in various fields. In the field of restoring cultural properties, it will show that it can be applied in practice by obtaining meaningful results. As a result of experimenting with the DCGAN and Style GAN algorithms among the GAN algorithms, it was confirmed that the DCGAN algorithm generates a top image with a low resolution.

한랭지역 철도역사 분석을 통한 건설기준 개선연구

정상필(Sang Pil Jung),김진욱(Jin Wook Kim),류경신(Kyung Shin Ryu),윤진현(Jin Hyun Yoon),노병국(Byoung Kuck Roh),박종원(Jong Won Park),고세원(Sae Won Go) 한국철도학회 2020 한국철도학회 학술발표대회논문집 Vol.2020 No.7

일본 한랭지역의 철도역사 현장답사를 위한 기초사례조사 연구

정상필(Sang Pil Jung),김진욱(Jin Wook Kim),류경신(Kyung Shin Ryu),윤진현(Jin Hyun Yoon) 한국철도학회 2020 한국철도학회 학술발표대회논문집 Vol.2020 No.7