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양동균,윤진상,이형영 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.2
Chronic antipsychotic treatment can induce tardive dyskinesia and supersensitivity psychosis, and these may be explained by supersensitivity phenomena of the dopamine receptor in the brain. This study was conducted to compare the clinical characteristics between tardive dyskinesia and supersensitivity psychosis in schizophrenia. The subjects of the study were composed of 8 schizophrenics with tardive dyskinesia(TD ), 10 schizophrenics with supersensitivity psychosis(SP), and 5 schizophrenics with both syndromes(TD with SP). They all had been treated with antipsychotics. We compared the difference in general and antipsychoti-related characteristics among the three groups. The results are as follows : 1) In the comparison of general characteristics ; There was a significant difference in the number of hospitalizations among the three groups. The number of hospitalizations was most frequent in SP group, and this was followed by TD with SP group(P<0.05). There was also a significant difference in the length of hospitalization : the longest in SP group and the shortest in TD group. Among the schizophrenic subtypes by Andreason-0lsen's criteria, the number of positive schizophrenics were significantly greater in SP and TD with SP group than in TD group(P<O.05) . 2) In the comparison of antipsychotic-related characteristics : There was a significant difference in the current antipsychotic dose among the three groups. The current antipsychotic dose was highest in SP group and this was followed by TD with SP group(P<0.05). The therapeutic response to antipsychotics was significantly better in SP group than in TD group, and the serum prolactin level was significantly higher in SP group than in TD group, and the serum prolactin level was significantly higher in SP group than in TD group(P<0.05; respectively) 3) Regardless TD, if SP was present, the serum prolactin level was significantly correlated to the current antipsychotic dose(P<0.05). 4) But, there was no significant difference in mean age, age of onset, duration, schizophrenic subtype by DSM-Ⅲ criteria, duration of antipsychotic treatment, prognosis, and antipsychotic potency among the three group.
Glycyrrhizince acid에 의해 유발된 Mineralocorticoid Excess Syndrome 1례
이종호,박동균,김태석,양동경,김득조,장호열,오수용 대한신장학회 1996 Kidney Research and Clinical Practice Vol.15 No.4
Glycyrrhizinic acid is an extract of licorice which is known to have mineralocorticoid effect by inhibiting lll3-hydroxysteroid dehydrogenase and allo- wing endogenous cortisol to bind mineralocorticoid receptor in kidney. We report a 59-year old female patient who had ingested 150mg of glycyrrhizinic acid daily for 3 months. She was found to have hypertension, hypokalemia(K: 1.8mEq/L), metabolic alkalosis and suppressed renin-aldosterone level. After stopping ingestion of glycyrrhizinic acid, her serum potassium level increased spontaneously in 5 days, but low renin-aldosterone level was persisted until discharge from hospital. We conclude that history of licorice(glycyrrhizinic acid) ingestion should be obtained in patients manifesting hypokalemia with metabolic alkalosis and hypertension.
안동규,남경흠,양동열,정찬균 한국정밀공학회 2009 International Journal of Precision Engineering and Vol.10 No.5
The deformation behavior and stress-strain relationships for a lightweight sandwich plate in the elastic regions are mainly dependent on the elastic properties of the core in the sandwich plate. The aim of this paper is to determine experimentally the elastic properties of a core in a thin sandwich plate with a metallic truss core. Threepoints bending experiments were performed to obtain a linear relationship between compliance per span length and the square of the span length for the designed sandwich plate. The specimen was manufactured from the continuous multi-points resistance welding of SUS 3O4H sheets and crimped metallic truss cores. The elastic and shear moduli of the core were estimated by the slopes and the intercepts of the linear relationship, respectively. Through the comparison of the shear moduli and force-deflection considering the core stiffness with those disregarding the core stiffness, it was shown that the core stiffness should be considered to estimate accurately the elastic and shear moduli of a core as well as the force-deflection curves of a thin sandwich plate with a metallic truss core. The contribution ratios of the bending and shear deflections of the thin sandwich plate to the total deflection were investigated. In addition, the influence of the crimping angle on the elastic properties, the forcedeflection curves, and the contribution ratios of both bending and shear deflections to the total deflection was examined.