http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Candida Albicans 와 Carcinogen 의 경구투여에 의한 Mouse 의 위점막 변화
정정명(Jung Myung Jung),김을수(Eul Soo Kim),오형석(Hyung Seok Oh),최경해(Kyung Hae Choi),이부경(Boo Kyung Lee),설상영(Sang Yung Sul),최하진(Ha Jin Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A 1) In the group of the subject mice administered with candida albicans only, all of 6 mice had an inflammatory change both in stomach antrum and body at the 1 month-interval check. At the 3 month interval check, an inflammation in stomach antrum occurred in all of 6 mice; however, in stomach body 5 mice had an inflammation and 1 mice a mocosal atrophy, At the 6 month-interval check, all of 8 mice had an inflammatory change in stomach antrum, while 4 of them got a mucosal atrophy in stomach body. 2) In the group of the mice with a carcinogen alone administered, 2 of 4 mice in the 6 month-group, and 5 of 8 mice in the 9 month-group revealed a mucosal dysplasia with no appearance of cancer. But the degree of dysplasia was one mouse in grade A and another one mouse in grade B, respectively, at the 6 month-interval check, while 2 mice in grade B, and 3 mice in grade C, respectively, at the 9 month-interval check. 3) In the group of mice administered both with carcinogen and candida albicans, 2 of 4 mice showed no cancer but mucosal dysplasia of grade B at the 6 month-interval check, while at the 9 month-interval check, 6 of 8 mice had a squamous cell cancer (especially 3 having been grossly examined) and the other two had mucosal dysplasia of grade C. 4) The findings in the liver tissue of the mice adminstered with the carcinogen for more than 8 months revealed a severe liver cell dysplasia with no evidence of hepatoma. 5) The results from this experimental study suggested that in case of provoking a stomach cancer due to a carcinogen administered in the mice, gastrointestinal infection of pathogenic organism such as candida does play a promoting role. However, whether a suggestion from this experimental study will be applicable to human beings as well or not will have to await a lot of further researches thereafter in the field, There have been reported many experimental researches on the oncogenic effects of various nitroso-compounds since Barnes and Magee, in 1956, concluded the acute hepatotoxicity and oncogenic action of dimethylnitrosamine in a number of experimental animals. Thereafter these nitroso-compounds have been assumed to be an environmental carcinogen in human beings as well as a potent carcinogen in animals. Much attention has been paid particulary on the relation of stomach cancer and nitrosamine since the nitrosamine synthesis in human gastric juice was known to be available. However. at present, it seems so hard to confirm nitrosamine as a vital factor of human cancer that far more information is demanded to identify it accurately. Recent reports, including ours, show a high frequency of candida albicans infection in gastrointestinal tract by various environmental factors. But the influence of candida multiplication on gastric ulcer or stomach cancer has scarcely been known. In this research we made a study of possible effects of candida infection on the gastric mucosa injury as well as on stomach cancer.
박경태,김을수,최영길,정정명,이부경,설상영,김기현 대한내과학회 1988 대한내과학회지 Vol.34 No.3
We had experienced a 34-year-old female patient with phlegmonous gastritis which was confirmed by radiologic studies and operation. Enterobacter aerogenes, E-Coli and Morganella morganii were cultured from the specimen of necrotic stomach tissue which was obtained by operation. The operation findings were revealed necrosis of total wall on the lower esophagus, stomach, duodenum and proximal portion of jejunum. The patient was rapidly deteriorated with downhill course and expired on 3rd hospital day.