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소화성궤양의 치료에 관한 연구 : 공격인자 억제제와 방어인자 항진제의 합병투여의 효과
박영태,이종철,송인성,최규완 ( Young Tae Bak,Jong Chull Rhee,In Sung Song,Kyoo Wan Choi ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1
The purpose of this study was to evaluate the therapeutic effect of defensive factor promotors in combination with H, receptor antagonist in peptic ulcer treatment. A prospective study was conducted on the open trial basis with consecutive method of medication. Diagnoses of total 58 patients(gastric ulcer: 36, duodenal ulcer: 22) were confirmed by gastroduodenoscopy. The patients were assigned to one of the following 3 treatment groups. Group A: 25 cases, Antacids+Cimetidine+Cetraxate, Group B: 18 cases, Antacids+Cimetidine+Sucralfate, Group C: 15 cases, Antacids Cimetidine. Each patient was followed up at 6 th week of treatment, and the therapeutic effect was evaluated. The results were as follows: Healing rates of gastric ulcers were Group A: 58. 3%, Group B: 50. 0%, Group C: 58. 3% ,,nd Total: 55. 6fc. There was no significant difference of healing rates among the groups. 2) Healing rates of duodenal ulcers were Group A: 92.3%, Group B: lpp 0%, Group C: 100. O>o and Total: 95. 5%. There was no significant difference of healing rates among the groups. But there was significant difference between gastric ulcers and duodenal ulcers. Alove results and those of previous study were compared together, and they revealed that there svas no significant difference of healing rates among the following G therapeutic groups: Antacids Cimetidine, Antacids+Cetraxate, Antacids+Sucralfate, Antacids TECA, Antacids+ Cimetidine+ Cetraxate, anrl Antacids+ Cimetidine+ Sucralfate.
B 형 간염 바이러스에 의한 간질환에서 혈청 B 형 간염 바이러스 DNA 의 검출 양상
박영태(Young Tae Bak),이창홍(Chang Hong Lee),유혜경(Hae Kyoung Yoo),문해란(Hae Ran Moon),최규완(Kyoo Wan Choi),김경호(Kyong Ho Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.3
N/A Serum HBV-DNA was measured by spot hybridization technique in 189 cases with HBsAg positive acute and chronic liver diseases, HBV-DNA was detected in 62% (68/110) of HBeAg positive, in 16% (10f62) of anti-HBe positive, and in 18% (3/17) of both HBeAg and anti-HBe negative patients. Cases with higher levels of HBV-DNA among HBeAg positive patients were significantly more than those among the HBeAg negative patients, Among the HBeAg positive patients, HBV DNA was detected in 36% of AVH, 86% of healthy carriers, 63% of CPH, 62% of CAI-l-m, 58% of CAH-s, 65% of LC, and 71% of HCC. Among the HBeAg positive patients, those with histologically minimal or mild inflammatory change (healthy carrier, CPH, CAH-m) had higher levels of HBV-DNA, and those with histologically greater inflammatory or destructive change (CAH-s, LC, HCC, AVH) had lower levels of HBV-DNA. Above results suggest that detection of serum HBV- DNA in patients with HBV-related liver diseases may be useful to evaluate the degree of viral replication and infectivity and to predict the histological severity and relative prognosis.
성인의 급성 설사에 대한 로페라미드 옥사이드의 효과 : 위약과의 무작위 이중 맹검 비교 다시설 시험
박영태(Young Tae Bak),이계희(Kye Heui Lee),한동수(Dong Soo Han),박중원(Joong won Park),김나영(Na Young Kim),윤병철(Byung Chul Yoon),이오영(Oh Young Lee),임선희(Seon Hee Lim),정희진(Hee Jin Jung) 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5
Background/Aims: Laperarnide is an esteblished treatment regimen for acute diarrhea. The prodrug loperamide oxide is converted to loperamide by the anaerobic bacteria in the lower gastrointestinal tract. When loperamide oxide with a low dose and a low plasma concentration was used, it was expected to obtain similar antidiarrheal effect as using loperamide. The incidence of adverse reactions might be reduced with the use of loperamide axide. According to a few reports from other nations, loperamide oxide was me effective than placebo. This study was perfomed to canfirm the antidiarrhea1 effect and the safety of loperamide oxide in Korean patients with acute diarrhea. Methods, Loperamide oxide (1 mg tablets) was compared with placebo in a double-blind placebo-contmlled treatment of acute diarrhea of 140 Korean patients from 5 university/general hospitals located at or around Seoul. Results: We completed such trial for one hundred and eleven (56 of placebo group and 55 of active drug group) cases. Number of consumed tablets were significantly less in active drug group (p=0.0005). The first relief was more frequently experienced (p=0.0032) and time taken upto the first relief was shorter (p=0.0471) in loperamide oxide treated group than in placebo group. Early event was more frequently experienced (p= 0.0001) in loperamide oxide group. Complete relief was more frequently experienced (p=0.0032) but not significantly shorter in loperamide oxide group. Both the patieats' visual analogue scale (p=0.0007) and the investigators' global assessment (p=0.0011) of the treatment significantly favored the loperamide oxide over placebo. No evidence of adverse reactions related to this drug was experienced. Conclusions: These results suggest that loperamide oxide can be used safely and effectively for the relief of acute diarrheal symptoms. (Korean J Gastroeoterol 1998;31:629 - 638)
Campylobacter pylori 감염의 비관혈적이고 신속한 진단을 위한 14C - urea Breath Teat
박영태(Young Tae Bak),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee),박승철(Seung Chull Park),조윤정(Yun Jeung Cho),김대원(Dae Won Kim),이갑노(Kap No Lee) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A During the recent several years, Campylobacter pylori organisms have been implieated in the gastroduodenal diseases including gastritis, duodenal ulcer, gastric ulcer, epidemic hypochlorhydria, nonulcer dyspepsia, etc. Diagnositc methods include culture of the organism, detection of the organism in the gastric mucosa, demonstrating urease activity and serology. Endoscopy with biopsy have been required for the detection methods. In an effort to avoid the expense and discomfort of endoscopy in patient selection and follow-up studies, 14C-urea breath test was done and compared with the other diagnostic methods. Campylobacter pylori culture and histological examination of gastric antral mucosa, Gram stain of gastrie juice, and 14C-urea breath test was done in 123 cases undergoing upper gastrointestinal endoscopic examinations. Diagnostic sensitivity of the urea breath test with cut-off value of 0.4% was 0.93, specificity was 1.00, and efficiency was 0.94%. Among the diagnostic tests for C. pylori infection, detection with Warthin-Starry silver stain and 14C-urea breath test were most efficient (0,92 & 0.94), In conclusion, 14C-urea breath test may be a simple, noninvasive, rapid and very efficient method for the detection of C. pylori infection of the stomach.
박영태(Young Tae Bak),인광호(Kwang Ho In),최석주(Seok Joo Choi),강경호(Kyung Ho Kang),김진호(Jin Ho Kim),박정의(Jeong Euy Park),김종극(Jong Guk Kim),이창홍(Chang Hong Lee),김학제(Hark Jei Kim),배정원(Jeoung Won Bae) 대한내과학회 1989 대한내과학회지 Vol.36 No.4
N/A Two cases of protein-losing enteropathy are reported. Protein-losing enteropathy due to constrictive pericarditis was diagnosed in a 17-year-old boy with a 1 year history of intermittent generalized edema and pleural effusion. His symptoms completely disappeared after a pericardiectomy. Another case of protein-losing enteropathy was found in a 23-year-old woman with a 4 year hstory of intermittent generalized edema and ascites. After an explorative laparotomy, intestinal lymphangiectasia was diagnosed. A low fat diet and oral prednisolone were prescribed and the patient returned to relatively good health without edema for 15 months.
박영태(Young Tae Bak),연종은(Jong Eun Youn),권소영(So Yung Kwon),김재선(Jae Seon Kim),이흥만(Heung Man Lee),변관수(Kwan Soo Byun),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee) 대한내과학회 1996 대한내과학회지 Vol.50 No.2
Objectives: Lump sensation in the throat is a common disorder. ft is generally considered to be a neurotic origin and ignored by many physicians. This study was done to evaluate the prevalence of the pharyngoesophageal structural lesions and the esophageal motility disorders among the patients with globus pharyngeus and to elucidate whether any specific manometric abnormality might have and causative role in the pathogensis of the globus sensation, and we also wanted to know whether such tests are necessary in evaluating those patients. Methods: 77 patients complaining globus sensation in the throat were enrolled, but 12 of them were excluded from this study due to other coexisting esophageal symptom(s) such as chest pain, dyspagia, hearburn, and/or regurgitation. Mean(±SD) age of the included 65 cases (M/F: 17/48) was 39.8(±10.3) years. Duration (median& interquartile range) of the symptom of globus sensation was 10(3-36) months. Mean(±SD) age of the 37 control subjects (M/F: 13/24) was 40.8(±13.0) years. Thorough throat and esophageal examinations including indirect laryngoscopy, esophagoscopy &/or barium pharyngoesophagography, and esophageal manometry were performed. Results: Structural lesions were demonstrated in 10 cases(15.4%) among 65 patients. But among 44 controls, there were also 4 cases(9.1%) of structural lesions, and there was no significant difference in the prevalence of the structural lesions between the patients and controls (p=0.5017). Manometric abnormalities over the lower esophageal sphincter and the lower esophageal body were demonstrated in 18 cases(27.7%) of the patients, while only 1 case(2.3%) of the controls revealed such abnormality(p=0.0015). Nonspecific esophageal motility disorder(14 cases) represented the most common abnormal finding among them. Other abnormalities were hypertonic lower esophageal sphincter (2 cases), diffuse esophageal spasm(1 case), and nut- cracker esophagus(1 case). Various manometric parameters of the upper esophageal sphincter and pharynx showed no difference between the patients and controls except the upper esophageal sphincter pressure at lateral sides which was lower in patients than in controls(p=0,0367). The meaning of this finding is unclear. Conclusion: Globus sensation is a predictor of esophageal dysmotility, and esophageal manometry is necessary to detect such abnormality in patients with glnbus sensation. The value of diagnostic tests to detect structural lesions in the pharynx and esphagus could not be affirmed
일상적 식도 내압 검사 도중 내압 검사 계측치들의 개인내 변이
박영태(Young Tae Bak),이구(Goo Lee),김재선(Jae Seon Kim),권소영(So Young Kwon),변관수(Kwan Soo Byun),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.6
Objectives: Routine esophageal manometry is a useful tool in evaluating patients with symptoms potentially of esophageal origin. Although many technological aspects became standardized, the actual methods of performing the manometries or interpreting the manometric data are not the same. There are still several questions to be answered regarding whether a period for practice or adaptation is necessary for the proper wet swallows, whether there is intraindividual variation of the manometric parameters, and how many wet swallows are required for the proper and efficient diagnosis of the esophageal motility disorders. Methods: To measure the degree of intraindividual variation of the manometric parameters of the lower esophagus during a routine esophageal manometry, and to know whether the variation can lead to the different manometric interpretations, we prospectively analyzed 100 consecutive patients undergoing routine esophageal manometries due to various esophageal symptoms. Lower esophageal sphincter pressure was measured by the station pull-through method, and a routine lower esophageal manometry was done using the stationary catheter method with 15 wet swallows. In each patient, contractions were divided into 3 groups following the first, second and third 5 consecutive swallows, and into 2 groups following the first and last 10 consecutive swallows. Mean values of amplitude, duration and velocity of the contractions and proportions of nontransmitted and simultaneous contractions were measured in each group and the manometric parameters were compared between groups. Diagnoses were made from the data from the first and the last 10 swallows. Results: Duration of the contractions became significantly prolonged in later periods of swallows statistically, but the difference was not clinically important. Other manometric parameters were not significantly different between different periods. Diagnoses made by the two sets of data were discordant in only 6 cases (6.0%). Conclusion: The result of this study suggests that 10 wet swallows are usually enough to measure the manometric parameters of the lower esophagus with relatively good accuracy in most patients undergoing routine manometries,
박영태(Young Tae Bak),김진호(Jin Ho Kim),목영재(Young Jae Mok),구범환(Bum Hwan Koo) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
The cases of 630 patients treated surgically at the Department of Surgery, Guro Hospital, Korea, University for primary gastric adenocarcinoma from September 1983 to June 1990 and followed unti December 1991 were reviewed to evaluate survival rate and prognostic variables which might affect survival of the patient. Twenty-seven patients were excluded from the study: 3 patients who died within 30 days of surgery and 24 patients who had incomplete data. A total of 603 patients were available for the study. Tumor resection was possible in 525 out of 603 patients(87.1%.). The 5-year survival rate was 48.0% for 603 patients treated surgically and 54.2%. for 525 patients undergoing resection..'in 78 unversecta ble patients, 3-year suvival rate was 3.2%. Correlation between prognostic variables and survival were attempted in 525 patients who under went resection. Age, sex and tumar location showed no significant influence on survival. This study inidcated that type of cancer, depth of invasion, size of tumor, lymph node metastasis, distant metastasis, histologic type and type of surgical treatment are significant prognostic factors for carcinoma of the stomach.