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인삼성분이 효모의 Alchol발효에 미치는 영향 3. Saponin pattern, pH 및 유기당 함량의 변화
박세호,유태종,이석건,Park, Se-Ho,Yu, Tae-Jong,Lee, Seok-Geon 고려인삼학회 1982 Journal of Ginseng Research Vol.6 No.1
This studies were conducted to investigate the changes of saponin pattern, pH and organic acid contents of malt wort added ginseng components during alcoholic fermentation by Sacch. uvarum. The results are as follows. Saponin patterns of fermented wort were same as that of the non- fermented wort, but the weight of former was decreased comparing to that of the latter. pH value of fermented wort contained 0.1∼0.5% of ginseng extract were almost same as that of control(PH 4.23). Lactate, pyruvate, succinate and fumarate, pyroglutarate and citrate contents of the fermented wort were increased by the addition of ginseng extract and pyruvate content, particularly, was increased from 28.4 to 214mg/100 ml while that of control was 33.2mg/100m1. Citrate content of fermented wort contained ginseng saponin was almost same as control (37. 5mg/100m1) . But pyruvate content was tower 4-8.6mg/100m1 than that of control(33.2mg/100m1) .
응급의료센터에 내원한 단일 장골 골절 환자의 진통제 투여에 미치는 인자에 대한 분석
박세호,민문기,류지호,김용인,박맹렬,박용면,염석란,한상균 대한응급의학회 2014 大韓應急醫學會誌 Vol.25 No.4
Purpose: Many patients complain of pain due to fracture inthe emergency department (ED). However, pain managementin these patients has not been performed well. Theobjective of this study is to describe analgesic utilization andassess factors associated with analgesic use in patientswith isolated long-bone fractures during the ED visit. Methods: We retrospectively reviewed electronic medicalrecords of patients presenting to two EDs with an isolatedlong bone fracture from January to December 2012. A totalof 358 patients were enrolled, and sex, age, arrival route,mechanism of injury, fracture type, fracture location, drugused for pain control, arrival time, physician in charge primarycare, and disposition were analyzed. Results: Analgesics were administered to 50% of patientsbetween 20~60 years, whereas 11.3% of patients under 20years old and 38.7% above 60 years old (p<0.01) receivedanalgesics. Better pain control was achieved in females,young adults, patients cared for by emergency medicineresidents, and visits made by emergency medical service orat dawn. Conclusion: The pain control rate of children is lower thanthat of adults in patients with an isolated long bone fracture. Active strategies for pain management are necessary bytriage physicians from this time forward.
인삼성분이 효모의 알콜저장에 미치는 영향 1. 효모의 생리에 미치는 영향
박세호,유태종,이석건,Park, Se-Ho,Yu, Tae-Jong,Lee, Seok-Geon 고려인삼학회 1981 Journal of Ginseng Research Vol.5 No.2
The effect of ginseng extract and ginseng saponins on alcoholic fermentation was studied 1. Alcoholic fermentation on gllicose medium at 30$^{\circ}C$. by Saccharomyces coveanus and Saccharomyces uvavum was stimulated when the media contained 5% and 10 % of ginseng extract, respectively. But that of Saccharomyces cerevisiae was inhibites by the addition of 10% of ginseng extract. 2. Saponin did not stimulate the alcoholic fermentation by Saccharomyces uvarum. 3. The yeast cell counts was increased remarkably by addition of ginseng extract while that of ginseng saponins was increased slightly. Dried cell weight of the broth which Contained 5% of ginseng extract was 3 times than that of control.
박세호,이지영,Park, Se-Ho,Lee, Ji-Yeong 한국공간정보학회 2009 한국공간정보학회지 Vol.17 No.3
효율적으로 데이터를 관리, 분석, 유지하기 위해서는 각 시스템의 목적에 맞는 데이터 모델이 필요하다. 데이터 모델에 따라 해당하는 활용 시스템의 활용 범위가 결정되며, 각각의 활용 시스템에 맞는 데이터 모델이 개발되고 있는 상황이다. GIS 분야에서도 각 GIS 응용시스템에 맞는 다양한 공간정보 데이터 모델들이 개발 되었으며, 제공하고자 하는 서비스에 따라 공간정보 데이터 모델이 만들어지고 있다. 어플리케이션의 효율적인 활용을 위해서는 공간정보 데이터의 정확성과 최신성등이 중요하지만 특히 공간정보 데이터 구조를 만드는 데이터 모델링이 중요하다. 그러므로 본 연구는 1)국내외 공간정보 데이터 모델의 공간정보를 표현하는데 있어 기하학적 모델, 위상학적 모델과 3차원 공간정보 가시화 방법 등의 항목별로 비교하고 2)각각의 데이터 구조를 분석하여 데이터 모델의 특징을 비교한다. 마지막으로 3)공간정보 데이터 모델을 선정하여 정량적인 분석을 통해 데이터 구조에 따른 특징을 분석한다. Each system should have a suitable data model about their purpose for efficiently managing, analyzing, and manipulating data. And the usable range of application is determined by the data model, and suitable data models are being developed for each application. In GIS, diversity spatial data model is being developed too. The accuracy and update of the spatial data would be important for applying efficient application as well as the data modeling is important as constructing the spatial data structure. Therefore, the purposes of this research are to 1)compare domestic spatial data models with oversea spatial data models about their geometry model, topology model and visualizing method of 3D spatial data 2)to compare the features of the data model by analyzing each data structures. We 3)compare and analyze features of each spatial data models via the quantitative analysis of each spatial data models.
박세호,이승태 한국도로학회 2021 도로 : 도로학회지 Vol.23 No.3
PURPOSES : In this study, experimental findings regarding the frost resistance of concrete incorporated with mineral admixtures such as fly ash (FA) and ground granulated blast-furnace slag (SG) are presented. METHODS : To evaluate the performance of the abovementioned concretes under repeated freezing and thawing environments, based on the ASTM C 666 standard, the relative dynamic modulus of elasticity and mass ratio measurements are performed regularly. Furthermore, based on the ASTM C 672 standard, the concretes are exposed to 4% CaCl2 and NaCl salt solutions along with repeated 50 cycles of freezing and thawing. Subsequently, the scaling resistance is evaluated based on the scaled-off mass content and visual examination. RESULTS : SG is less effective in enhancing the scaling resistance of concrete compared with FA. However, the concrete incorporated with SG is more resistant to repeated freeze-thaw actions compared with OPC concrete. Meanwhile, compared with OPC concrete, the concrete incorporated with FA indicates a similar performance in terms of scaling resistance and better resistance against repeated freeze-thaw actions. CONCLUSIONS : The frost resistance of concrete depends significantly on the types of mineral admixtures used in concrete. This emphasizes the importance of selecting the appropriate binder to achieve durable concrete pavements in cold climate regions.
유방암 세포주에 에스트로겐 및 항에스트로겐 처치에 따른 coregulators, MAP kinase 활성도 및 세포주기 조절인자 p27/kip1의 변화
박세호,허민규,이미정,김주희,박병우 한국유방암학회 2008 Journal of breast cancer Vol.11 No.2
Purpose: Estrogen, various polypeptide hormones and growth factors are associated with the development and progression of breast cancer. Coregulatory proteins are also associated with estrogen receptor (ER) transcriptional activity and tamoxifen resistance. Therefore, it is necessary to investigate the change of coregulator mRNAs and various cell proliferation proteins and cell cycle-related proteins after treatment with estrogen or antiestrogen. Methods: MCF-7 cells were maintained in dextran-coated charcoal stripped 10% Dulbecco's Modified Eagle Medium (DMEM). To measure the change of the coactivators’ (src-1, P/CAF, CBP, AIB1) mRNAs and corepressors’ (SMRT, N-coR) mRNAs, multiple PCR was carried out using specific primers. In addition, intracellular proteins related to cell proliferation and cell cycle regulation were measured by performing Western blotting after treatment with estrogen or tamoxifen. The change of mitogen activated protein kinases was also measured by performing Western after tamoxifen treatment for 4 weeks. Results: Coactivator mRNAs expression rapidly decreased in 15 minutes after estrogen treatment but this recovered to the initial level in 3 hours. The pattern was similar for the case of tamoxifen treatment. Corepressor mRNAs expression rapidly decreased in 15 minutes after estrogen treatment and it remained at a lower level until 24 hours after estrogen treatment. With tamoxifen treatment, the initial response was similar to the cases of estrogen treatment, but the expression gradually increased 3 hours after tamoxifen treatment. Treatment of estrogen induced intracellular concentrations of c-myc and Ki-67 and it increased nuclear translocation of NF-kB and phosphor-ERK and it decreased the intracellular cell cycle suppressor p27/kip1. Tamoxifen treatment increased nuclear p27/kip1 but it decreased c-myc, NF-kB and phosphor-ERK. Long-term (4 weeks) treatment of tamoxifen was associated with decrease of activated ERK and p38 but there was no change in phospho-Akt level. Conclusion: Estrogen induced cell proliferation and the survival pathway-related factors, but it decreased the cell cycle suppressor p27/kip1. Long-term treatment with antiestrogen tamoxifen might decrease the MAPK activities in ERα-expressing tumor cells.