간 경변 진단시 신경망을 이용한 분류기 구현

박병래 한국지능정보시스템학회 2005 지능정보연구 Vol.11 No.1

This paper presents the proposed a classifier of liver cirrhotic step using MR(magnetic resonance) imaging and hierarchical neural network. The data sets for classification of each stage, which were normal, 1type, 2type and 3type, were analysis in the number of data was 231. We extracted liver region and nodule region from T1-weight MR liver image. Then objective interpretation classifier of liver cirrhotic steps. Liver cirrhosis classifier implemented using hierarchical neural network which gray-level analysis and texture feature descriptors to distinguish normal liver and 3 types of liver cirrhosis. Then proposed Neural network classifier learned through error back-propagation algorithm. A classifying result shows that recognition rate of normal is 100%, 1type is 82.8%, 2type is 87.1%, 3type is 84.2%. The recognition ratio very high, when compared between the result of obtained quantified data to that of doctors decision data and neural network classifier value. If enough data is offered and other parameter is considered, this paper according to we expected that neural network as well as human experts and could be useful as clinical decision support tool for liver cirrhosis patients. 자기공명영상과 계층적 신경망을 이용하여 간경변증을 단계별로 분류하고자 하였다. 내원한 231명의 데이터를 분석하였으며, 각 단계별 분류는 정상, 1, 2, 3단계로 분류하였다. T1강조 자기공명 간 영상으로부터 정상 간 실질과 간 경변 결절을 추출하고, 간 경화증의 단계를 객관적으로 해석 분류하였다. 간 경변 분류기 구현은 계층적 신경망을 이용하였고, 명암도 분석과 간 결절 특성을 통하여 정상간과 3단계의 간 경변으로 구분하였다. 제안한 신경망 분류기는 오류 역전파 알고리듬을 이용하였다. 분류결과 인식율이 정상군은 100%, 1 단계는 82.8%, 2 단계는 87.1%, 3 단계는 84.2%의 분류율을 나타내었다. 신경망 분류 결과와 전문의 판독 결과를 서로 비교한 결과 인식률은 매우 높게 나타났다. 만일 더욱더 충분한 데이터나 파라미터를 가지고 지속적으로 수행한다면 간 경변 환자들에게 임상적으로 지원하는 도구뿐만 아니라 의료전문 신경망으로도 기대된다.

3차원 MR Angiography DICOM 영상을 이용한 가상혈관경의 임상적 유용성

박병래,강세식,김화곤 대한의료정보학회 2004 Healthcare Informatics Research Vol.10 No.3

Objective : To evaluate of virtual angioscopy was implemented using MR(magnetic resonance) angiography image of carotid artery.Methods : The endoscopy system provides a 3D volume rendered image as a navigation map and has the multi planar reformation image along the path and a 2D axial image as a reference image. We segmented the common carotid artery and internal, external carotid artery from the MR angiography image. We used the coordinates as a navigation path for virtual camera that were calculated from medial axis transformation. We used the perspective projection and marching cube algorithm to render the surface from volumetric MR angiography image data.Results : The virtual angioscopy is highly recommended as a diagnosis tool with which the specific place of stenosis can be identified and the degree of stenosis can be measured qualitatively.Conclusion : Virtual angioscopy is one of the powerful tool for non-invasive carotid artery and many in-vitro, in-vivo studies have shown the artery stenosis detection. Inside of the carotid artery is one of the body region not accessible by real optical endoscopy but can be visualized with virtual endoscopy.

말부리 외 1편

박병래 향토문학연구회 2010 향토문학연구 Vol.13 No.-

Magnetic Resonance Imaging and Pathologic Correlation of Cerebral Fat Embolism using Oleic Acid

박병래 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.2

To investigate the correlation between the magnetic resonance imaging (MRI) of cerebral fat embolism that is induced by injecting oleic acid into 10 cats, and a pathologic diagnosis. Using a microcatheter, 30 μl of oleic acid was injected into the internal carotid artery of 10 cats. MR T2-weighted image (T2WI), diffusion-weighted image (DWI) and Gadolinium-enhanced T1-weighted image (Gd-enhanced T1WI) were obtained after 30 minutes and 2 hours of embolization. After 30 minutes of the embolization, lesions of very high signal intensity were detected by T2WI in 6 cats, and of slightly high signal intensity in 2 cats; in the remaining 2 cats, signal intensity was normal. DWI showed lesions of very high intensity in 9 cats and of slightly high intensity in one cat. According to the findings of light microscopic examination, infarcted lesions mainly involved the gray matter, but also some white matter. A magnetic resonance imaging diagnosis for cerebral fat embolism that was induced by oleic acid through the internal carotid artery in cats showed high signal intensity on the T2WI and the DWI within an initial 2 hours, and with a well enhancement on the Gd-enhanced T1WI. Considering cellular edema, cerebrovascular injury and extracellular space widening, we assumed pathologically that cytotoxic and vasogenic edema exists at the same time.

Association of common promoter polymorphisms of MCP1 withhepatitis B virus clearance

박병래,Yoon Jun Kim,Hyun Sub Cheong,김영효,Yoo Hyun Choi,Hyo-Suk Lee,신형두 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.6

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including AGT), cadherin 1 (CDH1), cyclooxy-genase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymor-phisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis con-trolling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A alle ( MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was sig-nificantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.

Max Scheler 知識社會學의 認識前提와 그 方法論的 意義

朴柄來 대구효성카돌릭대학교사회과학연구소 1992 사회과학연구 Vol.1 No.-

韓國 福祉政策의 方向과 課題 : 醫療保障을 중심으로 the Medical Security system

朴炳來 대구효성카돌릭대학교사회과학연구소 1998 사회과학연구 Vol.5 No.-

The purpose of this study is to examine Medicare system of Korea. There are many problems in korean Medicare system, especially unreasonableness of levy a medical premium, limit and level of insurance money payment etc. This study shows that the development of Korean Medicare system was influenced by socio-structural elements and socio-economic aspects. The former is a strong bond of Korean family, nonofficial social support, nonofficial cultural solidarity etc., the latter is the phase and level of economic development. Therefore this study come to the conclusion that its demand for explanation about the relations between the policies of medical insurance and the characteristics of the phase and level of nation development.

AngioSURF를 이용한 전신 3D MR Angiography

박병래,강세식,고성진,김화곤 대한방사선사협회 2003 대한방사선사협회지 Vol.29 No.1

MR 관류영상을 이용한 고양이 대뇌 혈류량의 동적특성 변화

박병래,김학진,전계록 대한의용생체공학회 2004 의공학회지 Vol.25 No.4

자기공명 관류영상기법을 이용하여 고양이 뇌 지방색전증 유발한 후 대뇌혈류량을 정량적으로 분석하고 동적특성 변화를 구현하고자 하였다. 고양이 44마리를 대상으로 일측 내경동맥에 트리올레인 (n=15), 올레익 (n=9) 및 리노레익 (n=11)을 주입하여 뇌 지방색전을 유발시켰고, 대조군으로는 이바론 입자 (n=9)를 주입하여 색전이 유발되게 하였다. 그 후 30분과 2시간에 각각 T2강조, 확산강조영상을 획득하고 가장 색전이 많이 일어난 부위에서 관류강조영상을 얻었다. 획득한 데이터는 자체 개발한 영상처리 프로그램과 IDL 소프트웨어를 이용하여 신호강도 곡선을 ΔR$_2$* 곡선으로 변환한 후 적분하여 뇌혈류량을 측정하였다. 모든 군에서 병변부위의 뇌혈류량은 정상부위에 비해 감소하였다. 실험 각 군별 뇌혈류량 비는 시간경과에 따라 유의한 차이가 있었으며 (P<0.005), 2시간에서는 30분에 비해 뇌혈류량이 다소 회복되었다. 뇌 지방색전증의 초기에는 혈류량이 감소하였다. 뇌경색 발생시 조기에 DWI와 PWI을 획득하여 뇌 혈류량의 다양한 동적변화 특성 및 혈류역학적 변화에 대한 정보를 임상적으로 제공 할 수 있으리라 여겨진다. This study was to quantitative analysis compare to dynamic characteristic change of the regional cerebral blood volume (rCBV) after development of cerebral fat embolism in cats using perfusion MR Imaging. Forty-four adult rats were used. Triolein (n = 15), oleic acid (n = 9) and linoleic acid (n = 11) were injected into the internal carotid artery using microcatheter through the transfemoral approach. Polyvinyl alcohol (Ivalon) (n = 9) was injected as a control group. Perfusion MR images were obtained at 30 minutes and 2 hours after embolization, based on T2 and diffusion-weighted images. The data was time-to-signal intensity curve and ΔR$_2$* curve were obtained continuously with the aid of home-maid image proc in.leased significantly at 2 hours compared with those of 30 minutes (P<0.005). In conclusion, cerebral blood flow decreased in cerebral fat embolism immediately after embolization and recovered remarkably in time course. It is thought that clinically informations to dynamic characteristic change of the cerebral hemodynamics to the early finding in cerebral infarction by DWI and PWI

企業創業과 立地要因

朴炳來 慶北大學校 經營大學院 1989 最高經營者課程 論文集 Vol.- No.10