http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Omeprazole - cholestyramine resin 제제의 위산분비에대한 억제효과
이영욱(Young Wook Lee),김일웅(Ill Woong Kim),정지훈(Ji Hoon Jeong),라현오(Hyun O La),최경범(Kyeong Bum Choi),이남인(Nam In Lee),손의동(Uy Dong Sohn),허인회(In Hoi Huh) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.4
We have examined inhibitory effects on gasritis using omeprazole-cholestyramine resinate, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. To test the pharmacological action of this, we investigated the effect of omeprazole-cholestyramine resinate on indomethacin-induced gastritis in rats. Omeprazole was used as a reference drug. Orally administered omeprazole-cholestyramine resinate inhibited the indomethacin-induced gastritis in a dose-dependent manner. The inhibitory effect of omeprazole-cholestyramine resinate on the gastritis was similar to that of reference drug. In addition, rectal adminstration of the omeprazole-cholestyramine resinate inhibited the indomethacin-induced gastritis in a dose-dependent manner. The inhibitory effect of omeprazole-cholestyramine resinate was equipotent to reference drug. The basal gastric acid secretion was decreased when it was administered either orally or rectally. This inhibition of omeprazole-cholestyramine resinate was similar to that of omeprazole. These data suggest that omeprazole-cholestyramine resinate inhibit the gastritis in rats, and are comparable to omeprazole available in market.
Ginkgolide B 유도체인 SKI 5051의 항 혈소판 응집작용
김윤철,김학철,이남인,라현오,김진학,송현주,손의동,허인회 중앙대학교 약학연구소 1999 약학 논총 Vol.13 No.-
This study was performed to test the antiplatelet aggregating effect of a derivative of Ginkgolide B(SKI 5051) alone and with calcium antagonist and aspirin on the mouse pulmonary thromboembolism and collagen-induced rabbit platelet aggregation. Ginkgolide B is a potent PAF antagonist, which was isolated from the leaves of Ginkgo biloba and 10' -(3,5-Dimethylpyridine-2-methoxy) Ginkgolide B(SKI 5051) is a derivative of Ginkgokide B. A derivative of Ginkgolide B(SKI 5051) protected mice from sudden death by collagen and epinephrine mixture and inhibited collagen-induced rabbit platelet aggregation dose-dependently. These effects increased by concurrent administration with aspirin and verapamil. These results suggest that a derivative of Ginkgolide B(SKI 5051) is a effective drug for preventing disease associated with platelet aggregation and this effect is increased by concurrent administration with calcium antagonist and aspirin.