상악동 골이식술을 위한 이식재의 부피 측정 - CT를 이용한 환자 대조군 연구

김형욱,이슬기,정재안,신진업,엄윤섭,김기영,김종식,송윤정,홍순민,박준우,Kim, Hyung-Wook,Lee, Seul-Ki,Chung, Jae-An,Shin, Jin-Eob,Um, Yun-Sub,Kim, Ki-Young,Kim, Jong-Sik,Song, Yun-Jung,Hong, Soon-Min,Park, Jun-Woo 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.5

Purpose: The aim of this study is to determine whether a difference in the amount of bone graft material is needed between edentulous patients and dentulous patients and to calculate the amount of augmentation for a sinus lift procedure. Methods: 19 patients(20 sinuses) were included to measure maxillary sinus volume. Facial CT scanning was performed using MX 8000 IDT CT devices(Philips, USA). And it was used for IDLvm(The IDL Virtual Machine) 6.0, CT Volume Analyzer Ver 2.3 program to measure maxillary sinus volumes Results: At edentulous patients, volumes(mean${\pm}SD$) of the inferior portion of the sinuses were $0.56{\pm}0.13cm^3$(5mm height), $2.35{\pm}0.57cm^3$(10mm height), $4.85{\pm}1.10cm^3$(15mm height). At dentulous patients, volumes(mean${\pm}SD$) of the inferior portion of the sinuses were $0.41{\pm}0.18cm^3$(5mm height), $1.76{\pm}0.42cm^3$(10mm height), $3.80{\pm}0.84cm^3$ (15mm height). A significant correlation was found between augmentation height(5mm, 10mm, 15mm) and the calculated sinus volume.(p=0.027, p=0.018, p=0.044) Conclusions: A significant correlation was found between augmentation height(5mm, 10mm, 15mm) and the calculated sinus volume. Detailed preoperative knowledge of sinus lift augmentation volume is helpful in determining the appropriate amount of the bone graft material.

치주병소 골흡수 측정시 정량분석형 계수공제영상 방사선 측정법에 대한 실험적 연구

김형욱,정종평,Kim, Hyoung-Uk,Chung, Chong-Pyoung 대한치주과학회 1990 Journal of Periodontal & Implant Science Vol.20 No.2

폐쇄성 수면무호흡증의 치료에 사용되는 하악전방이동장치-'바이오가드'의 안전성과 유효성 검증을 위한 전향적, 다기관, 단일군 및 비열등성 연구

김형욱,황청풍,은헌정,Kim, Hyoung Wook,Hwang, Chungpoong,Eun, Hun Jeong 대한수면의학회 2016 수면·정신생리 Vol.23 No.2

목 적 : 본 연구의 목적은 폐쇄성 수면무호흡증의 치료에 사용되는 하악전방이동장치의 한 제품인 '바이오가드'의 유효성과 안정성을 확인하는 것이다. 방 법 : 코골이 및 수면무호흡으로 내원한 총 62명의 환자를 대상으로 하여 하악전방이동장치를 치료법으로 선택하여 전향적, 다기관, 비열등성 연구를 하였다. 일차적으로 설문지 및 야간수면다원검사를 통해 수면무호흡지수의 변화를 수술적 치료의 선행 연구 결과와 비교한 비열등성 연구를 하였고 이차적으로 수면의 질, 주간졸리움, 산소포화도, 코골이 비율의 변화를 '바이오가드' 사용전후와 비교하였다. 또한 이상반응발생을 조사하여 안정성을 평가하였다. 결 과 : 62명의 환자 중 중도 탈락한 3명을 제외한 59명에게서 MAD 치료 5주 뒤에 평가한 수면무호흡지수의 변화는(54%) 수술적 치료의 선행 연구 결과(45%)와 비교하여 통계적으로 유의한 차이를 보이지 않았다(95% CI). 코골이 비율의 변화를 제외하고 수면무호흡지수, 수면의 질, 주간졸림증, 산소포화도는 통계적으로 유의한 개선을 보였다(p < 0.001). 총 62명 중 39명(62.9%)의 대상자에게서 총 85건의 이상반응이 보고되었으며 대부분(78건, 91.8%)의 경우 경증으로 보고되었고 중증으로 보고된 2건의 경우는 바이오가드와의 연관성은 없는 것으로 밝혀졌다. 결 론 : 하악전방이동장치의 한 제품인 '바이오가드'는 코골이와 수면무호흡 환자에게 안전하고 효과적인 치료방법이다. 따라서 기존의 비가역적인 수술 치료법을 시도하기 전에 적용하는 대체치료법으로써 우선적으로 고려하여 사용할 수 있을 것이다. Objectives: The purpose of this study was to estimate the safety and efficacy of a mandibular advancement device (MAD), 'Bioguard,' for the treatment of obstructive sleep apnea (OSA). Methods: In this 5-week prospective, multi-center, single group, and non-inferiority trial, patients who chose 'Bioguard' as their treatment option were evaluated using both questionnaires (Pittsburgh Sleep Quality Index (PSQI), Epworth sleepiness scale (ESS)) and polysomonography (PSG) (apnea hypopnea index (AHI), oxygen saturation). All patient data, including clinical records, PSG studies (both pre- and post-treatment), and adverse events (AEs), were reviewed and analyzed. Results: Results were obtained for 59 of 62 patients (95.16%). No significant difference in success rate was found between the MAD treatment and surgical treatment (95% CI). AHI, PSQI, ESS and oxygen saturation demonstrated significant improvement (p < 0.001) after MAD treatment, and 39 of 62 patients (62.9%) reported 85 AEs. 79 of the 85 AEs (91.8%) were mild cases, and there were no severe AEs related to the MAD treatment. Conclusion: The MAD 'Bioguard' should be considered as an alternative treatment option for OSA patients.

항공방위산업의 경쟁력 확보 방안

김형욱,Kim, Hyeong-Uk 한국방위산업진흥회 1996 國防과 技術 Vol.- No.212

지난 8월 30일 한국산업개발연구원내 방위산업센타 설립을 축하하는 "국가안보와 항공방위산업"을 주제로 한 특별세미나가 하얏트호텔에서 있었다. 에어쇼를 개최하고 21세기의 국가산업으로 발돋움하려는 항공산업의 향후 전망을 살펴보는 기회로 주제발표내용들을 요약해 보았다.

방위산업 경영합리화 방안(4)

김형욱,Kim, Hyeong-Uk 한국방위산업진흥회 1998 國防과 技術 Vol.- No.232

방위산업의 경영합리화를 위해서는 기술집약형 군사력 건설을 지원하고 정부와 업체가 함께 참여하는 방산체제 구축과 함께 기존 생산분야는 수요지향적으로, 신규분야는 기술 및 지식집약형으로 방산구조를 조정해야 한다

방위산업 경영합리화 방안(2)

김형욱,Kim, Hyeong-Uk 한국방위산업진흥회 1998 國防과 技術 Vol.- No.230

국내 방산의 구조조정 필요성 및 문제점을 바탕으로 방산소요 부족에 따른 생산물량 감소와 첨단기술분야의 기술수준 취약 및 경영의 취약점을 보완할 수 있는 방향으로 구조조정을 하여야 할 것이다. 또한 앞으로 이러한 문제에 초점을 맞추어 방위산업을 미래 지향적인 국가산업으로 발전시킬 수 있는 새로운 방산체제 및 지원 대책이 논의되어야 한다.

랫드에서 cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R)의 아급성독성시험에 관한 연구

김형욱,강경선,신동진,조재진,김배환,서광원,남기환,이영순,Kim, Hyoung-Ook,Kang, Kyung-Sun,Shin, Dong-Jin,Cho, Jae-Jin,Kim, Bae-Hwan,Seo, Kwang-Won,Nam, Ki-Hoan,Lee, Yong-Soon 한국독성학회 1992 Toxicological Research Vol.8 No.2

This study was performed to determine the toxic effects of graded dose levels of SKI 2053R after repeated administration. Three groups of Sprague-Dawley rats(10M and 10F per group) were given a total of 25 i.v. injections of SKI 2053R (1.50,3.75,9.38mg/kg/day). In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group of Sprague-Dawley rats (10M and 10F per group) were given a total of 25 i.v.injections of cisplatin (1.70mg/kg/day). The dosing schedule was divided into five courses of 5 consecutive days with 16-day dose-free intervals between each course. No drug-related toxicity occurred in low dose level group (1.50mg/kg/day) of SKI2053R. From the results of hematological examination, peripheral WBC counts, RBC counts and hemoglobin of high dose level group(9.38mg/kg/day)of SKI 2053R were significantly lower than those of no-treated group. Other toxicities including reduced final body weight, proteinuria and hematuria were observed in high dose level group of SKI 2053R. But, no change was detected in serum biochemical values of SKI 2053R treated groups. All of the rats in cisplatin treated group were died between 3 and 13 weeks, while rats treated with SKI2053R survived to the end except one rat of middle dose level group(3.75mg/kg/day). In histopathological examinations, rats that received cisplatin manifested severe tubular damage in kidney and hemosiderosis in spleen, but no critical pathological lesion was observed in rats of other groups. Considering the results of this study, it was concluded that non-toxic dose of SKI 2053R in this treatment schedule was estimated to be 3.75 mg/kg/day and the maximum tolerated dose was to be higher than 9.38mg/kg/day. The toxic profiles fo SKI 2053R were different from those of cisplatin, and its toxicity was considerably lower than that of cisplatin.

임상가용 아동 및 청소년을 위한 외상 후 스트레스장애 척도를 통한 학교폭력 피해아동의 인지행동집단치료 효과 : 예비연구

김형욱,김태형,은헌정,최말례,권태완,구정일,조수진,송옥선,Kim, Hyoung-Wook,Kim, Tae-Hyoung,Eun, Hun-Jeong,Choi, Mal-Rye,Kwon, Tae-Wan,Ku, Jeong-Il,Cho, Soo-Jin,Song, Ok-Sun 대한불안의학회 2007 대한불안의학회지 Vol.3 No.2

Objective : The present study was carried out in order to assess the effects of Cognitive-Behavioral Group Therapy (CBGT) on victims of school violence, as assessed by the CAPS-CA. Methods : The subjects were 14 children who had experienced school violence and were subsequently diagnosed with PTSD and partial PTSD using the Clinician-Administered PTSD scale for Children and Adolescents (CAPS-CA). Seven children agreed to participate in CBGT, and they received 10 sessions of therapy. After CBGT, both the CBGT and non-CBGT groups were assessed using the CAPS-CA and School Adaptation Test. Results : The study results showed significant decreases in avoidance (p=0.010) and hyperarousal in the CBGT group (p=0.009) following the completion of CBGT. The analysis of school adaptation showed that there was a significant improvement in peer relationships after CBGT in the CBGT group (p=0.045). Conclusion : CBGT is effective in improving PTSD symptoms in children who experience school violence and subsequently suffer from PTSD.

석유화학공업의 수요예측 및 분석 - 다변수회귀분석 및 소비원단위를 중심으로 -

김형욱,배도선 ( Hyeong Ug Kim,Do Sun Bai ) 한국화학공학회 1976 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.14 No.5

A good business forecasting or demand forecasting can contribute greatly to a nation`s economic planning. For a desirable economic planning, it is necessary to be able to predict fufure business conditions. An accurate demand forecasting for many goods can help achieve the nation`s economic planning by eliminating material wastages and controlling unnecessary oversupplies of material which are caused by unbalance in the demand and supply relationships. In an attempt to satisfy these needs, the present paper purports to conduct a demand forecasting (1976-1981) for the overall products of domestic petro-chemical industry. Thus the following methods are used as the appropriate approach for this purpose. (1) First, as the goods which are needed for this study, 18 items of final products (ten items of synthetic resins, four of synthetic fibers and four of synthetic rubbers) and 32 items of intermediate products and raw materials are selected among the overall products of the industry. (2) A multiple regression analysis is conducted to forecast demand for the final products. (3) Manufacturing consumption coefficients and modifier coefficients are used to forecast demand for the intermediate products and raw materials.

동맥경화증의 실험동물 모델화와 식이섬유의 동맥경화 방어기전에 관한 연구

김형욱,이영순,이흥식,신광순,임창형,Kim, Hyoung-ook,Lee, Yong-soon,Lee, Heung-shik S,Shin, Kwang-soon,Lim, Chang-hyeong 대한수의학회 1993 大韓獸醫學會誌 Vol.33 No.3

mechanisms for the hypocholesterolemic effects of $\beta$-glucan remain unclear. Rats were divided into 3 groups ; normal control group, atherogenic group(oral administration of cholesterol 40 mg/kg/day plus vit. $D_2$ 320,000 IU/kg/day), $\beta$-glucan treatment group(atherogenic treatment plus $\beta$-glucan 0.135 g/kg/day). The $\beta$-glucan treatment group showed moderate increases of serum lipids concentration compared with atherogenic group. In histopathological examination, aortas showed no critical lesions. The total fecal neutral sterols and bile acids excreted for 6 days was increased compared with both normal and atherogenic group. To compare effects of soluble fiber and insoluble fiber extracted from barley on postprandial lipemia, 5 healthy male adults ingested on separate days a low-fiber(total dietary fiber 2.61g) control meal or dietary fiber-enriched(12.61g) meals. Fasting and postprandial blood samples were obtained for 6.5h and serum lipids were analyzed. The serum total lipids, total cholesterols, LDL & VLDL-cholesterol were markedly reduced with soluble fiber-enriched meals, but no decrease with insoluble fiber-enriched meals. These results suggest that mechanisms for the hypocholesterolemic effect of $\beta$-glucan on rats were due to the inhibition of cholesterol absorption in the intestinal lumen and acceleration of cholesterol catabolism in the liver. And the soluble dietary fiber($\beta$-glucan) has the hypocholesterolemic effect by dropping serum LDL & VLDL-cholesterol in the clinical study.