정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

경년열화를 고려한 전단벽 구조물의 기계학습 기반 지진응답 예측모델 개발

김현수,김유경,이소연,장준수,Kim, Hyun-Su,Kim, Yukyung,Lee, So Yeon,Jang, Jun Su 한국공간구조학회 2024 한국공간구조학회지 Vol.24 No.2

Machine learning is widely applied to various engineering fields. In structural engineering area, machine learning is generally used to predict structural responses of building structures. The aging deterioration of reinforced concrete structure affects its structural behavior. Therefore, the aging deterioration of R.C. structure should be consider to exactly predict seismic responses of the structure. In this study, the machine learning based seismic response prediction model was developed. To this end, four machine learning algorithms were employed and prediction performance of each algorithm was compared. A 3-story coupled shear wall structure was selected as an example structure for numerical simulation. Artificial ground motions were generated based on domestic site characteristics. Elastic modulus, damping ratio and density were changed to considering concrete degradation due to chloride penetration and carbonation, etc. Various intensity measures were used input parameters of the training database. Performance evaluation was performed using metrics like root mean square error, mean square error, mean absolute error, and coefficient of determination. The optimization of hyperparameters was achieved through k-fold cross-validation and grid search techniques. The analysis results show that neural networks and extreme gradient boosting algorithms present good prediction performance.

스카이브릿지 설치위치에 따른 고층건물의 진동제어 성능평가

김현수,박용구,고현,이의현,이동근,Kim, Hyun-Su,Park, Yong-Koo,Ko, Hyun,Lee, Ui-Hyun,Lee, Dong-Guen 한국공간구조학회 2010 한국공간구조학회지 Vol.10 No.3

In this study, the vibration control effect according to the installation location of the sky-bridge and the difference of natural periods of the connected buildings has been investigated. To this end, 40-story and 50-story building structures connected by a sky-bridge were used as example structures and the equivalent modeling method was used. Boundary nonlinear time history analyses were performed using El Centro and Taft earthquakes to investigate the dynamic behavior of the example structures and vibration control effect of the sky-bridge. Based on numerical results, it has been shown that displacement responses can be effectively controlled as the installation floor of the sky-bridge increases and acceleration responses can be effectively reduced when the sky-bridge is installed on the mid-stories of the example building. 본 연구에서는 스카이브릿지 설치위치 및 연결된 구조물의 고유진동주기 차이에 따른 전체 구조물의 진동제어 효과를 분석하였다. 이를 위하여 스카이브릿지로 연결된 40층과 50층 구조물을 예제 구조물로 사용하였고, 등가모형화기법을 이용하여 예제 모델을 구성하였다. El Centro 및 Taft 지진을 사용하여 경계비선형 시간이력해석을 수행하였고 구조물의 동적거동과 진동제어 효과를 분석하였다. 해석결과 변위응답은 스카이브릿지를 상부층에 설치할수록 더 효과적으로 제어할 수 있었고 가속도응답은 구조물의 중간층부근에 설치할 때 더 효과적으로 저감시킬 수 있었다.

Rat periodontal ligament cell에서의 RANKL mRNA의 발현

김현수,정현주,김영준,김옥수,Kim, Hyun-Soo,Chung, Hyun-Ju,Kim, Young-Joon,Kim, Ok-Su 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.2

As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor $^{\kappa}B$ ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease. This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1 ${\beta}in$ the concentration of $0.01{\sim}10$ ng/ml. The results are as follows; 1. Periodontal ligament cells which stimulated by 1L-1 ${\beta}$ increased soluble RANKL synthesis by dose-dependent pattern in the concentration of $0.01{\sim}10$ ng/ml. 2. 1L-1 ${\beta}$ induced mRANKL expression in dose-dependent manner in the concentration of $0.01{\sim}5$ ng/ml. 3. mOPG expression was not to be influenced by 1L-1 ${\beta}$. These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.

비대칭 구조로 이루어진 불안정 공진기형 Nd : YAG 레이저의 빔질 분석

김현수,Kim, Hyun-Su 한국광학회 2005 한국광학회지 Vol.16 No.5

제2조화파 발생용으로 사용되는 볼록평면거울로 구성된 비대칭 불안정 공진기형 Nd:YAG 레이저의 빔질 특성을 수치적으로 분석하였다. 분석은 $M^2$, 공진기 내에서의 빔허리 직경, 모드 부피의 계산을 통해서 이루어 졌다. 수치적 계산 결과는 레이저 헤드가 볼록레이저 거울 근방에 위치한 비대칭 공진기 구조가 될 때 고효율의 제2조화파를 발생할 수 있는 조건이잘 충족됨을 보였다. We numerically investigate the characteristic of single Nd:YAG rod laser with the convex-plane resonator configuration in order to get the best condition for high efficient intra-cavity second harmonic generation(SHG). The beam quality is analyzed with ABCD matrixes including the thermal lensing characteristic of Nd:YAG rod. The analysis is focused on stability, M2, beam waist and mode-volume of laser beam inside the resonator. The best conditions for SHG is obtained when a laser rod is set near the curved laser mirror.

액침진탕 배양에 의한 Monascus sp . 가 생산하는 적색색소에 관한 연구 (제2보) 적색조색소의 생산과 물리적 성질 및 생리적 성질

김현수,곽효성,양호석,변유량,유주현 ( Hyun Su Kim,Hoy Sung Kwak,Ho Suk Yang,Yu Ryang Pyun,Ju Hyun Yu ) 한국미생물생명공학회 1979 한국미생물·생명공학회지 Vol.7 No.1

두개의 렌즈형 레이저 막대들로 구성된 대칭형 공진기의 안정도 및 빔질의 수치적 분석

김현수,Kim, Hyun-Su 한국광학회 2004 한국광학회지 Vol.15 No.6

두개의 렌즈형 레이저 막대들로 구성된 대칭형 레이저 공진기의 안정도와 빔질 특성을 분석하고 열 복굴절 보상 특성을 수치적으로 분석하였다. 공진기는 열 효과에 의한 이중초점을 제거하기 위한 90$^{\circ}$ 회전자가 두개의 렌즈형 레이저 막대 사이에 삽입된 구조로 되어있다. 수치 분석을 통해 레이저 막대를 오목렌즈로 만들 경우 고출력 영역에서 안정도가 증가하고 빔질이 향상됨을 보였다. 또한 두개의 레이저 막대를 서로 맞댄 공진기 구조에서 열 복굴절이 잘 보상될 수 있음을 보였다. We analyse the beam characteristics of the thermal-birefringence compensated symmetric resonator which consists of two laser rods with rod-end curvatures. The numerical results show that the stability and the beam quality can be improved in high power operation region when the rod-ends are made in the form of a negative lens. The thermal birefringence of the symmetric two-rods resonator is shown to be well compensated when the two rods closely contact each other.

렌즈형 레이저 막대들로 구성된 대칭형 Nd:YAG 레이저의 출력 특성 분석

김현수,이성만,이용주,Kim, Hyun-Su,Lee, Sung-Man,Rhee, Young-Joo 한국광학회 2006 한국광학회지 Vol.17 No.2

두개의 렌즈형 Nd:YAG 막대들로 구성된 두 종류의 대칭형 레이저 공진기에 대한 공진기 안정도, 빔질 특성($M^2$)과 레이저 출력 등을 비교 분석하였다. 실험은 두개의 레이저 막대를 서로 근접시킨 구조의 레이저와 레이저 막대가 레이저 거울에 각각 거의 밀착된 구조의 레이저를 이용하여 수행하였다. 또한복굴절 보상 소자를 두 종류의 공진기에 사용했을 때의 레이저 출력 특성도 비교 분석하고 수치 해석하였다. Resonator stability condition, $M^2$ beam quality factor, and laser output power are analyzed for two types of two-rod Nd:YAC lasers with rod-end curvatures. Two laser rods with rod-end curvatures are positioned closely to each other or placed separately near each resonator mirror. Experimentally, the output powers and $M^2$ beam quality factors of those lasers are measured with and without thermal birefringence compensation, and compared to numerical analyses.

일방향 중공슬래브의 휨강도 산정방법에 관한 연구

김현수,임준호,강주원,Kim, Hyun-Su,Lim, Jun-Ho,Kang, Joo-Won 한국전산구조공학회 2012 한국전산구조공학회논문집 Vol.25 No.6

중공슬래브 시스템은 슬래브 두께가 증가해도 자중은 크게 증가하지 않고, 일반슬래브에 비해서 휨성능이 크게 저하되지 않는 장점이 있다. 이러한 경제적인 건물 설계 및 친환경 구조물 구현을 가능하게 하는 시스템에도 불구하고 중공슬래브의 활용도는 현재로서는 낮다고 할 수 있다. 특히 국내의 건축분야에 있어서는 매우 낮은 편이다. 이러한 현 상황의 가장 큰 이유는 중공슬래브의 적용을 위한 구조 해석 및 설계방법이 일반화되어 있지 않다는 것이다. 본 연구에서는 실질적인 압축영역을 고려하기 위해 가정한 중공 단면형상에서 중립축 위치에 따른 압축응력블럭의 체적으로 휨강도 산정식을 제시하였다. 기존 중공부 상부만을 압축영역으로 고려한 휨강도 산정방법은 가장 보수적인 방법으로 판단되며 2개의 대체단면을 설정하여 휨내력을 산정하는 것이 더 실질적인 방법으로 판단된다. The hollow slab has advantages that its self-weight does not greatly increase notwithstanding the increase of its thickness and its flexural performance does not significantly degrade in comparison with general reinforced concrete slab. However, the utilization of the hollow slab is currently being underestimated in spite of structural system that enables economic design of building and construction of eco-friendly structure. the significant reasons for this situation is that the method of structural analysis and design for hollow slab is not generalized. In this study, to consider practical compressive zone of hollow slab, the equation for its flexural strength is proposed by the volume of compressive stress block according to neutral axis location in hollow section assumed. Existing estimation method of flexural strength of hollow slab considering only compressive zone above hollow part is evaluated as the most conservative method and the method estimating flexural strength by two alternative cross-section of hollow slab is evaluated as more practical method.

다중 스마트 TMD를 이용한 대공간 아치구조물의 지진응답 제어

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2016 한국공간구조학회지 Vol.16 No.1

A novel vibration control method for vibration reduction of a spacial structure subjected to earthquake excitation was proposed in this study. Generally, spatial structures have various vibration modes involving high-order modes and their natural frequencies are closely spaced. Therefore, in order to control these modes, a spatially distributed MTMDs (Multiple TMDs) method is proposed previously. MR (Magnetorheological) damper were used to enhance the control performance of the MTMDs. Accordingly, MSTMDs (Multiple Smart TMDs) were proposed in this study. An arch structure was used as an example structure because it has primary characteristics of spatial structures and it is a comparatively simple structure. MSTMDs were applied to the example arch structure and the seismic control performance were evaluated based on the numerical simulation. Fuzzy logic control algorithm (FLC) was used to generate command voltages sent for MSTMSs and the FLC was optimized by genetic algorithm. Based on the analytical results, it has been shown that the MSTMDs effectively decreased the dynamic responses of the arch structure subjected to earthquake loads.