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김종혁 ( Kim Jong Hyeog ),노영준 ( No Yeong Jun ),김지연 ( Kim Ji Yeon ),문성용 ( Mun Seong Yong ),김현우 ( Kim Hyeon U ),김진건 ( Kim Jin Geon ),이정훈 ( Lee Jeong Hun ),노지호 ( No Ji Ho ),천병철 ( Cheon Byeong Cheol ),이관행 ( 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3
Mitochondrial myopathies are diseases caused by defects in metabolic pathway of mitochondria. Mitochondrial myopathy is known as one of the causes of recurrent myoglobinuria, while clinically, rarely causes acute renal failure requiring medical treatments. We report a case of rhabdomyolysis and acute renal failure associated with mitochondrial myopathy. A 58-year-old male was presented with dyspnea and hypotensive shock. The patient had a history of recurrent dark colored urine and cramping leg pain after prolonged fasting. Laboratory findings showed hyperkalemia, azotemia, metabolic acidosis, and elevated AST, ALT, and creatinine kinase. He had no history of trauma or medication. Muscle biopsy showed ragged red fibers in modified Gomori staining. On electron microscope, increased number of mitochondria and abnormal mitochondria were seen. He received hemodialysis and his renal function recovered after 1 month. (Korean J Nephrol 2004;23(3):509-513)
신동훈 ( Sin Dong Hun ),김종혁 ( Kim Jong Hyeog ),김지연 ( Kim Ji Yeon ),노영준 ( No Yeong Jun ),문성용 ( Mun Seong Yong ),김진건 ( Kim Jin Geon ),김현우 ( Kim Hyeon U ),이정훈 ( Lee Jeong Hun ),이서진 ( Lee Seo Jin ),김연수 ( Kim 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5
We report an unusual case of adult minimal change nephrotic syndrome relapsed after 15-year of complete remission. In this case, the disease had occurred to the patient for the first time when he was 52 years old; relatively high age, and had been remitted with steroid therapy. After 15 years of complete remission, he visited our hospital with the symptoms of the generalized edema and the pitting edema of both lower extremities that occurred 15 days ago. Massive proteinuria(15,865 ㎎/day) and hypoalbuminemia(1.7 g/㎗) were detected. The pathologic evaluation of the biopsied specimen of the kidney showed he global sclerosis in 19% of glomeruli in light microscopic finding and the fusion of epithelial foo processes in electron microscopic finding. He was treated with pulse steroid therapy(methylprednisolone 500 ㎎/day iv for 3 days) and then, with oral prednisolone (60 ㎎/day). Generalized edema and proteinuria disappeared after 14 days of treatment, and there has been no relapse ever since. Adult-onset minimal change nephrotic syndrome relapses within 4 years after complete remission in 90% of relapsed patients. The relapse after more than 5 years of complete remission, like this case, is very rare, especially in he case of late-onset disease. However, the possibility of relapse of the minimal change nephrotic syndrome after several years of its remission should be considered constantly and the long-term follow-up more than 10 years may be needed. (Korean J Nephrol 2003;22(5):608-611)
450 N급 메탄-산소 로켓 엔진을 위한 스파크 토치 점화기 개발
박신영(Sinyoung Park),최이담(Edam Choi),한은조(Eunjo Han),김진건(Jin Geon Kim),이다혜(Dahae Lee),이은광(Eunkwang Lee),이민우(Minwoo Lee) 항공우주시스템공학회 2024 항공우주시스템공학회지 Vol.18 No.1
Adopting an engine igniter with high efficiency and ignition performance is essential for reliable operation of liquid rocket engines. In this study, we developed a spark torch igniter for a 450 N-scale methane-oxygen liquid rocket engine by conducting numerical analyses, igniter manufacturing and validation. Specifically, we conducted a parametric study for maximizing the enthalpy at the igniter exit, specifically by adjusting the mass flow rate, nozzle area ratio, fuel-oxidizer mixture ratio, and the igniter length-to-diameter. The heat transferred via the igniter nozzle exit was computed using 3-dimensional numerical simulations. We also manufactured and tested the igniter based on a deduced design to confirm ignition performance of the designed spark torch igniter. The igniter developed through this study could contribute to the development of practical propulsion systems such as upper-stage engines of small launch vehicles.