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이상희 ( Lee Sang Hui ),김종석 ( Kim Jong Seog ),김청미 ( Kim Cheong Mi ),김보욱 ( Kim Bo Ug ),황주연 ( Hwang Ju Yeon ),조희영 ( Jo Hui Yeong ),김두표 ( Kim Du Pyo ),이윤호 ( Lee Yun Ho ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.5
In prenatal diagnosis of neural tube defects, maternal serum α-fetoprotein (MSAFP) level in second trimester is used as a screening test. However, it shows low sensitivity with high false positive rate. Also, α-fetoprotein and acetylcholinesterase in amniotic fluid through amniocentesis is used, but it is an invasive technique with low sensitivity. Recently, due to improved prenatal sonography, typical sonographic findings of spina bifida are reported and contributed to early diagnosis and detection of possible co-existing abnormalities. We report a case of spina bifida detected at 21 weeks of pregnancy by prenatal sonograph at our institution with a brief review of literature.