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김두일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2
The coronary artery disease, which include silent ischemia, stable angina, unstable angina, and myocardial infarction, is major cause of death and disability in Korea. Their pathophysiologic basis may be related to increased oxygen demand in the setting of flow limiting lesion, vasospasm, thrombus. Although coronary artery disease is a condition of diverse etiologies, most common cause is atherosclerotic disease of epicardial coronary arteries. The treatment of coronary artery disease is classified four department such as control of risk factor, medical treatment, coronary revascularization procedure(percutaneous coronary intervention, coronary artery bypass graft). Medical treatment include beta-blocker, antiplatelet agent, calcium channel blocker and lipid lowering drug et al. adequate combination of drugs is needed to patients control. While the basic management of patients with coronary artery disease is medical treatment, many patients are improved by coronary revascularization procedure. Interventions should not replace continuing need to early symptoms and modify risk factors. So combination of treatment(control of risk factor, medical treatment, coronary interventions, surgery) is important patient treatment.
일제에 의해 제작된 만주지도의 현황과 연구에 대한 소고
김두일 원광대학교 2007 圓光軍事論壇 Vol.- No.3
The purpose of this study is to survey the present situation of collection of and research on the Manchurian maps made by Imperial Japan. 'Maps on Foreign Countries' were made on vast areas from Kamchaka to the north to Australia to the south and from India to the west to Alaska to the east. The maps are now kept mainly in colleges and research institutes in addition to the National Diet Library in Japan. Such countries as USA, England, Korea and China also have maps. For example, Seoul National University in South Korea has almost complete set of 1: 500,000-scale map and several small scale maps on Manchuria. Various materials on the process of map-making exist in Japan. Several volumes of the chronicles on the Land Survey Bureau of Imperial Japan are available in addition to a few materials on the process of surveying and map-making on Manchuria. Systematic research on 'Maps on Foreign Countries' in Japan is still in the early stage, mainly focusing on the inventory of maps within Japan and abroad. Such topics as cartographic characteristics of maps, map contents and their military use, international cooperation for the study of these maps and others should be studied for the understanding of Manchurian maps.
흰쥐 심장조직에서 식염부하에 의한 Natriuretic Peptides의 변화에 대한 면역조직화학적 연구
김두일,김동수 인제대학교 1998 仁濟醫學 Vol.19 No.2
Atrial natriuretic peptide(ANP)는 나트륨 이뇨, 이뇨 및 혈관 확장 등의 작용을 가지고 있는 심장 호르몬으로서 체액, 전해질 및 혈압의 항상성을 유지하며, brain natriuretic peptide(BNP) 역시 신경펩티드로서 ANP와 유사한 작용을 가지는 호르몬으로 알려져 있다. 본 연구에서 저자들은 흰쥐에서 식염부하를 시도하여 심장조직에서 면역조직화학염색법으로 ANP와 BNP의 면역반응성의 분포를 조사하여 그것의 활성도 및 반응의 지속 정도를 알아보고, 또한 혈장 삼투질 농도 및 Na+ 농도 변화를 관찰하였다. Objectives: Atrial natriuretic peptide(ANP) is a cardiac hormone with diuretic, natriuretic, and vasorelaxant activities, and it is implicated in the control of blood pressure, body fluid, and cardiovascular homeostasis. Brain natriuretic peptide(BNP) forms a peptide family with ANP and may be involved in the regulation of blood pressure and fluid volume, as is ANP. It has been reported that natriuretic responses are altered by changes in extracellular fluid(ECF) volume. Methods and Materials: To assess the compensatory mechanism of ANP and BNP in response to ECF volume alterations, we examined the distribution of immunohistochemically identified cells for ANP and BNP in the heart tissues of salt-loaded rats using immunohistochemical method and also investigated the process, activity, maintenance of reaction during salt intake. In addition, plasma osmolality, plasma sodium concentration were measured in association with changes in salt intake. Results: 1. Plasma osmolality increased wish advancing salt intake, but plasma sodium concentration was greater than the comparable values in the control group at the third day of salt intake. 2. The distribution of ANP-immunoreactivity in the heart was wider in the right atrial tissue. The ANP-immunoreactivity was more intense in right aerial tissue, interventricular septum and coronary sinus at the third day of salt intake and became weaker from the seventh day of salt intake. The BNP-immunoreactivity in the heart tissue was observed a group of many immunopositive cells in right atrial tissue, left ventricular tissue, interventricular septum at the fifth day of salt intake. Thereafter it was decreased gradually and seemed to be exhausted from the tenth day of salt intake. Conclusion: ANP and BNP are factors that maintain the homeostatic balance of body fluid during salt intake. However further investigation on these plasma levels, receptor binding, and biological activity is required to exactly understand its participation and importance in the natriuretic peptides hormonal system.