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임인서(In Seo Lim),이건웅(Gun Young Lee),전상현(Sang Hyun Chun),김근호(Gheun Ho Kim),구자룡(Ja Ryong Goo),전노원(Rho Won Chun),채동완(Dong Wan Chae),김형직(Hyung Jik Kim),노정우(Jung Woo Noe) 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: Several factors have been raised as contributing to morbidity and mortality among patients with end-stage renal disease treated with hemodialysis. We performed this study to evaluate morbidity and the factors contributing to them in chronic hemodialysis patients. Methods. We analyzed retrospectively the demo- graphic chracteristics, regularly tested laboratory findings (CBC, blood chemistry, chest X-ray, ECG), hospitalization rate, and gross mortality among 84patients in the Hallym University Medical Center from February I, 1992 to January 31, 1994. Results: 1) Age distribution of the patients was 54±13(mean±SD) years (range, 23-79 years); 41 patients were men, 43patients were women: 30patients(35.7%) had diabetes. The duration of hemodialysis was 33±30 months (range, 3-125 months). 2) Forty four patieints(52.4%) required hospitalization during the 2-year follow-up period, and the most common causes of hospitalization were infection and cardiovascular disease. 3) A total of 1H(21.4%) of the patients died the 2-year follow-up period, and cardiovascular disease was commonest cause of death. 4) The factors such as advancing age, the duration of hemodialysis, and diabetes were neither associated with the risk hospitalization nor with that of death. The serum albumin concentration in dead patients(3.4±0.4g/d1) was lower(p<0.001) than that in survived patients(3.8±0.4g/dL). As compared with patients who had serum albumin concentration ≥3.5g/dL, patients with serum albumin concentration <3.5g/dL had increased odds ratio(8.14) for death. The serum creatinine concentration in dead patients (9.5+3.0g/dL) was lower(p<0.%! than that in survived patients(11.8±3.1g/dL). Conclusion: We concluded that regularly tested serum albumin concentration was the most important predictive factor for death in chronic hemodialysis patients.
만성신부전 환자에서 심근 troponin I와 T 및 CK-MB의 진단적 의의
윤정이(Jung E Yun),이형철(Hyung Cheol Lee),이준상(June Sang Lee),박규용(Kyu Yong Park),박대균(Dae Kyun Park),구자룡(Ja Ryong Goo),김형직(Hyung Jik Kim),김근호(Gheun Ho Kim),전노원(Rho Won Chun),채동완(Dong Wan Chae),노정우(Jung Woo N 대한내과학회 2000 대한내과학회지 Vol.58 No.2
N/A Background : Nonspecific elevations of CK-MB, cTnT have been well known in patients with chronic renal failure(CRF) on maintenance hemodialysis. It has been suggested that recently developed cTnI seldom shows nonspecific elevations in these patients. Status of CRF patients can be divided into three groups: predialysis group, hemodialysis group and peritoneal dialysis group. Until now, most researchers have studied CK-MB, cTnT and cTnI only in CRF patients receiving maintenance hemodialysis. No previous studies have ever compared the differences of the nonspecific positivity of CK-MB, cTnT and cTnI according to the different status of CRF patients. Methods : Nonspecific positive ratios of cTnI, cTnT, & CK-MB in were evaluated 20 predialysis patients, 13 CAPD patients and 20 hemodialysis patients. No one had had any evidence of myocardial ischemia during the previous 3 months before the study entry. The predialysis group was again divided into two groups according to the cut off level of serum creatinine of 3.0 mg/dl. Authors also compared the nonspecific positive ratios of cTnI, cTnT, CK-MB between diabetic CRF group and non diabetic CRF group. The sensitivity, specificity and false positive ratios of each enzymes were examined on and 6 hours after arrival in 21 CRF patients who visited the emergency room with the complaint of chest pain. Results : 1) There were no nonspecific significant elevations of cTnI in CRF patients regardless of the status of CRF. But there were significant nonspecific elevations of CK-MB, cTnT in them. It was more marked in cTnT especially with the cut-off value of 0.1 ng/ml. 2) Nonspecific positive ratios of cTnT was significantly increased in diabetic CRF patients. 3) The sensitivity and specificity of cTnI were 100% and 93.3% each, which were significantly higher than those of CK-MB(83.3%, 66.7%) & cTnT(66.7%, 53.3%). Conclusion : In CRF patients, the nonspecific positive ratios of CK-MB, cTnT were higher than that of cTnI, and only cTnI did show significant specific elevations in all the CRF patients with acute myocardial infarction. It is likely that the status of CRF patients, dialysis mode, the sampling time point would not give significant changes in the nonspecific positive ratios of CK-MB, cTnT and cTnI.(Korean J Med 58:204-212, 2000)
송헌호 ( Hun Ho Song ),오순옥 ( Soon Ok O ),김수호 ( Su Ho Kim ),문상호 ( Sang Ho Moon ),김진봉 ( Jin Bong Kim ),윤종우 ( Jong Woo Yoon ),구자룡 ( Ja Ryong Koo ),홍경순 ( Kyung Sun Hong ),이명구 ( Myung Goo Lee ),김동준 ( Dong Joo 대한내과학회 2002 대한내과학회지 Vol.63 No.5
N/A Background : Since Plasmodium vivax malaria reemerged in Korea in 1993, a number of patients with malaria have been reported. We analyzed the cases with malaria who lived in Chuncheon and neighboring communities to find out clinical manifestations, laboratory findings and the differences in clinical findings compared to previous studies. Methods : We reviewed the clinical records of the cases who were confirmed as malaria by peripheral blood smear in Chuncheon Sacred Heart Hospital from July, 1998 to Octorber, 2001. Results : Forty-four cases were included. All cases were Plasmodium vivax with high fever, but tertian fever developed only in 15 patients (35.7%). A number of cases showed various symptoms including headache, abdominal pain, nausea, vomiting. Of the all cases, 41 cases (93.2%) developed malaria between June and September. Thrombocytopenia was prominent finding which was noted in 75% of the cases at diagnosis, and recovered during or after treatment. Other laboratory abnormalities such as anemia, elevated transaminases, coagulopathies, and elevated LDH level were also noted. Five patients were performed CSF studies, one patient showed pleocytosis in CSF. Conclusion : We observed that only 15 patients (35.7%) had tertian fever, the others had variable fever patterns. Thrombocytopenia was the prominent findings. Therefore we suggest that malaria should be included in the differential diagnosis of febrile diseases which developed from June to September regardless of the fever patterns. (Korean J Med 63:546-551, 2002) Key Words : Malaria, Fever, Thrombocytopenia