SNS의 서비스특성과 상호작용성이 신뢰와 결속에 미치는 영향

경종수(Jong-Soo Kyung),김명수(Myung-Su Kim) 국제e-비즈니스학회 2012 e-비즈니스 연구 Vol.13 No.3

일차 배양 흰쥐 간세포에서 사염화탄소 유발 세포독성에 대한 수종 생약 용매 분획의 억제효과 검색과 in vivo 간보호 작용 평가

김영숙(Young Sook Kim),경종수(Jong Su Kyung),박기현(Ki Hyun Park) 대한약학회 1996 약학회지 Vol.40 No.1

Solvent fractions were prepared from traditional herbal drugs which of methanol extracts inhibited CCl4-induced cytotoxicity in primary cultured rat hepatocytes and continuously assayed their effects. Ethylacetate and n-buthanol fractions from Cibotii Rhizoma and chloroform fraction from Gelatina Nigra inhibited the release of LDH and GPT from CCl4-treated hepatocytes, respectively. Water fraction (WAR) among solvent fractions from Astragali Radix showed the most potent inhibitory effect on the release of GOT or GPT by treatment with CCl4. All of solvent fractions prepared from Eucommiae Cortex had no effect on CCl4-induced cytotoxicity. Chloroform and ethylacetate fractions from Rehmanniae Radix Preparata increased the release of GPT from CCl4-treated hepatocytes. n-Hexan, chloroform or ethylacetate fraction from 5 herbal drugs increased the release of LDH, GOT or GPT from normal hepatocytes at the dose of 1.Omg/ml. Administration of WAR suppressed the elevation of GOT, ALP activities and MDA contents in the serum as well as in the liver tissue of CCl4-intoxicated rats. Based on these results, isolation of antihepatotoxic substances from WAR is under the process.

다이옥신 유도 독성에 대한 홍삼 비사포닌 분획의 방어효과

곽이성(Yi Seong Kwak),경종수(Jong Su Kyung),정명균(Myung Gyun Jung) 한국약용작물학회 2021 한국약용작물학회지 Vol.29 No.3

Background: This study has been carried out to investigate the protective effect of Korean Red Ginseng Non-Saponin Fraction (RGNSF) on clinical chemical parameters in male rats acutely exposed to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD). Methods and Results: RGNSF was prepared from red ginseng residues after ethanol extraction of red ginseng. The RGNSF was characterized by the saponin and free sugars of TLC. RGNSF did not contain saponin compounds and consisted of several sugars such as glucose, galactose, and sucrose. To investigate the protective effect of RGNSF on TCDD, forty male rats (Sprague Dawley, 180 ± 20 g) were divided into 4 groups. The normal control group (NC) received the vehicle (i.p.) and saline (p.o.) daily. The only TCDD treated group (TT) received a single dose of TCDD (40 ㎍/㎏, i.p.) and saline. The RGNSF receiving groups were administered p.o. at a daily dose of 100 ㎎/㎏ (RGNSF100) and 200 ㎎/㎏ (RGNSF200) for 3 weeks beginning a week before TCDD exposure. Body-weight gain of TT and RGNSF100 were inhibited after TCDD exposure. The body-weight of RGNSF200 was increased throughout the experimental period, although the increasing rate was slower than that of NC. A decrease in testis weights for the male rats due to TCDD exposure was significantly observed in the RGNSF200 group. Body-weight gain inhibition and the recovery of testis weight by RGNSF administration were dose dependent. Increases in WBC, RBC, hemoglobin, and hematocrit by TCDD intoxication were attenuated by RGNSF administration but were not significant. Increasing AST toxicity by TCDD was significantly inhibited by RGNSF administration with a dose-dependent manner. Conclusions: These results suggest that RGNSF might be a useful protective agent against TCDD, an endocrine disruptor.

랫드에서 potassium bromate에 의한 신장 및 간의 산화적 손상에 대한 홍삼 사포닌의 방어효과

황석연(Seok-Youn Hwang),강은경(Eun Kyung Kang),위재준(Jae Joon Wee),경종수(Jong-Su Kyung),조정희(Jung-Hee Cho),김윤배(Yun-Bae Kim) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3

Potassium bromate (KBrO₃), used as a food additive in bakery, has been found to cause problems due to its strong pro-oxidant property. It has been reported that Panax ginseng possesses protective effects against a variety of oxidative damage induced by chemicals such as carbon tetrachloride, acetaminophen, chrome or hyperoxia. Therefore, this study was carried out to investigate the effect of Korean red ginseng saponin (RGS) against oxidative damage induced by KBrO₃ based on the parameters in blood, tissues and urine. Male Sprague-Dawley rats were orally administered with RGS (75 ㎎/㎏) for 2 days, challenged intraperitoneally with KBrO₃ (300 ㎎/㎏) 2 hr after the final administration of RGS, and 48 hr later, blood, kidney and liver tissues, and urine were collected. In hematological analysis, KBrO₃ remarkably increased white blood cells, which was somewhat reduced by treatment with RGS. In blood biochemistry, KBrO₃ markedly increased serum creatinine, blood urea nitrogen, aspartate aminotransferase and alkaline phosphatase, while it decreased uric acid and Ca⁺⁺ levels, indicative of renal and hepatic toxicities. Such changes were greatly attenuated by RGS treatment. Also, RGS recovered KBrO₃-induced decrease in K⁺ level, although it did not affect the changes in Cl⁻ and osmolarity. In addition, the increases in malondialdehyde contents in kidneys and liver caused by KBrO₃ were fully reversed by RGS. Furthermore, urinary excretion profiles of malondialdehyde and its adducts were affected by RGS treatment; i.e., whereas an increase in excretion of N-ε-(2-propenal)lysine following KBrO₃ challenge was markedly lowered, N-α-acetyl-ε-(2-propenal)lysine and free malondialdehyde were greatly increased by RGS administration. Summarizing the above results, it is suggested that RGS exert protective effect against the renal and hepatic toxicities of KBrO₃ by not only reducing oxidative radical reactions, but also enhancing renal excretion of toxic by-products.

배암차즈기와 홍삼 복합물의 호흡기 보호 및 질환 치료 상승 효과

신한재(Han Jae Shin),곽효민(Hyo Min Gwak),이문용(Moon Yong Lee),경종수(Jong Su Kyung),장경화(Kyoung Hwa Jang),한창균(Chang Kyun Han),양원경(Won Kyung Yang),김승형(Seung Hyung Kim) 한국약용작물학회 2019 한국약용작물학회지 Vol.27 No.3

Background: We recently reported that Salvia plebeia R. Br. extracts suppress leukotriene production and effectively inhibit the airway inflammatory response by modulating inflammatory chemokine and cytokine expression. Here, we investigated the synergistic airway anti-inflammation effect of Salvia plebeia and Panax ginseng (Korean red ginseng, KRG) that has been used to treat various immune diseases such as asthma. Methods and Results: To evaluate the synergistic airway anti-inflammatory effect of Salvia plebeia and KRG, we measured the inhibitory effect of monotheraphy with either or co-theraphy with both on leukotriene and reactive oxygen species (ROS) production. Using coal a combustion, fly ash, and diesel exhaust particle (CFD)-induced respiratory disease mouse model, we found that co-theraphy synergistically suppressed airway inflammatory signs such as alveolar wall thickness and collagen fibers deposition, and decreased the number of total cell, CD11b+Gr-1+ cells, and inflammatory cytokines (IL17A, TNF, MIP-2 and CXCL-1) in bronchoalveolar lavage (BAL) fluid. Conclusions: We confirmed respiratory protection as a therapeutic effect of the Salbia plebeia-KRG 3 : 1 complex (KGC-03-PS) via anti-tracheal muscle contraction and expectorant animal studies using a CFD-induced respiratory disease mouse model.

차세대분야 특화계획에 의한 산학협력 및 인력양성

이상호(Lee Sang-Ho),유승남(Yu, Seung-Nam),경종수(Kyung, Jong-Soo),한창수(Hahn Chang-Su) 한국산학기술학회 2009 한국산학기술학회논문지 Vol.10 No.8

세계적으로 로봇산업이 거대시장으로 급성장할 것으로 예상되면서, 많은 국가에서 정책적으로 로봇산업 발전 을 추진하고 있다. 이러한 추세에 발맞춰 대한민국에서도 정부의 전략적 주도하에 다양한 분야에서의 로봇개발이 수 행되고 있다. 이러한 연구개발 프로그램들은 산학협력을 통해 이루어지고 있으며, 더 나아가 기업의 애로기술을 해소 하기 위한 기술적인 지원 및 교육을 추구하는 인력양성 및 산학협력 확산 연계 프로그램을 포함하고 있다. 본 논문에서는 이러한 산학협동 프로그램의 잠정적인 성과에 대해 논하였다. 우선 차세대 특성화 계획에 포함된 각 각의 프로그램을 설명하고, 로봇 개발과 관련한 인력양성의 성과를 평가하였다. 마지막으로 이러한 프로그램들의 지 속적이고 바람직한 발전을 위한 방안을 고찰하였다. As expected that a robot-industry will grow up rapidly toward a huge market, many countries try to develop the official policies to support a robot-industry. Following this trend, many robot researches are proceeded in the various technical areas by the government-initiated R&D strategies in Korea. These R&D programs are archived by academic-industrial collaboration and furthermore, include the disseminated linkage of academic-industrial collaboration and the human resource development program which pursues the problem solving and technical training for companies suffered by several technical difficulties. This paper shows the several analyses and considerations of provisional results of these collaboration programs. First, each program of specialized plan for next generation is reviewed and the accomplishment of human resource development for robot research is evaluated. Finally, several considerations are represented for continuous and desirable expansion of these programs.

Inhalation study of fly ash and coal-burning smoke complex particles using BALB/c and C57BL/6 mice

Hyo-Min, Gwak(곽효민),Han Jae Shin(신한재),Moon Youn Lee(이문용),Mi Jang(장미),Chang Kyun Han(한창균),Jong Su Kyung(경종수),Seung Hyung Kim(김승형) 환경독성보건학회 2017 한국독성학회 심포지움 및 학술발표회 Vol.2017 No.5