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박쥐에서 분리한 Hantavirus의 병리조직학적 소견
조규봉 ( Kyu Bong Cho ),강치환 ( Chee Hwan Kang ),최승구 ( Seung Gu Choi ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2
A few hundred cases of hemorrhagic fever with rena1 syndrome (HFRS) have been caused by Hantaan virus and related viruses of Genus Hantavirus occur annua1y in Korea. It has been known that field and sylvatic mice, Apodemus agrarius and urban rats, Rattus norvegicus and R. rattus constitute the anima1-host reservoir in Korea. Recently, we have detected antibodies against Hantan virus in the sera of bats and isolated a Hantavirus(CUMC-92B48 virus) from lung tissue of a bat. We a1so tried to examine pathology of the bat-originated virus in suck-ling mice. In the pathologica1 findings of suck1ing mice inocu1ated intracerebra11y with the bat -originated virus, it was characterized by foca1 interstitia1 edema combined with nerve fiber, nucler degeneration and perivascu1ar lymphocyte infiltration in the brain. It was shown that congestion, hemorrhage and septa1 thickening in the lung, lymphocyte infi1tration to intra10bule and foca1 necrosis in hepatocyte, appearance of some ba1100ning degenerative cells in liver, and foca1 destroyed lymphoidfollic1es and marked congestion in spleen.
PCR-RFLP에 의한 대중목욕탕 내 Nontuberculous Mycobacteria의 동정
최승구 ( Seung Gu Choi ),송운흥 ( Woon Heung Song ),강치환 ( Chee Hwan Kang ),조규봉 ( Kyu Bong Cho ),이재상 ( Jae Sang Lee ),이장호 ( Jang Ho Lee ),김성일 ( Sung Il Kim ),지수일 ( Soo Il Jee ) 대한임상검사과학회 2008 대한임상검사과학회지(KJCLS) Vol.40 No.1
Thirty two of bathroom water samples from public bathroom in Seoul areas were examined using acid-fast staining, Lowenstein-Jensen (L-J) medium culture and PCR-restriction fragment length polymorphism (PCR-RFLP). In 6.25% (2/32) bathroom water samples, acid-fast bacilli were detected by AFB stain, and in 21.9% (7/32) bathroom water samples, acid fast bacilli grew on L-J media. Of them, six acid-fast bacilli were identified as Mycobacterium avium, and the other AFB as Mycobacterium szulgai by PCR-RFLP. These results are suggested that accidental nontuberculosis mycobacterial infection to a weakness person will be possible in public area.