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뇌출혈로 항응고제 사용이 불가능한 심부 정맥혈전증에 대한 혈부축어탕 치험례
강지석,박성환,송문구,안영민,안세영,이병철,Kang, Ji-Suck,Park, Sung-Hwan,Song, Moon-Koo,Ahn, Young-Min,Ahn, Se-Young,Lee, Byung-Cheol 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2
Objectives: Deep vein thrombosis (DVT) is a common complication among stroke patients. The implication of DVT progressing into a fatal pulmonary embolism is one of the main reasons treatment cannot be delayed. However, when there is a contradiction for anticoagulants, such intracranial hemorrhage (ICH), it is difficult to determine the course of treatment. Our team reports a case with both acute DVT and ICH who improved with herbal medicine Hyulbuchuko-tang. Methods : A patient with a variety of thrombosis risk factors (atrial fibrillation, DVT, Cb-inf with intracranial hemorrhage due to thrombolytic complications) showed classic symptoms of DVT (pain, edema, discoloration), disorientation and chest discomfort. The patient was administered Hyulbuchuko-tang three times a day for 24 days without any anticoagulants. Conservative therapy including elastic stocking and leg elevation was co-administered. Laboratory tests and extremity vascular Doppler sonography were carried out 3 times during the treatment period. Results : After our treatment period, both popliteal vein DVT and calf vein DVT were not discovered by sonography, and thrombosis derived factors (eg. D-dimer, fibrinogen) decreased. There was no sign of edema or discoloration after treatment, and the patient no longer complained of leg pain, disorientation or chest discomfort. Conclusion : From these results, we suggest that there is a positive effect of Hyulbuchuko-tang on DVT. Hyulbuchuko-tang should be considered as a treatment option when western medical procedures are unavailable.
뇌경색 환자의 경동맥 초음파 검사와 24시간 홀터 검사와의 연관성 연구
강지석,박성환,송문구,안영민,안세영,이병철,Kang, Ji-Suck,Park, Sung-Hwan,Song, Moon-Koo,Ahn, Young-Min,Ahn, Se-Young,Lee, Byung-Cheol 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2
Background : Stroke is the second leading cause of death in Korea, following cancer. Stroke consists of ischemic and hemorrhagic stroke, and ischemic stroke can be largely classified as atherothrombotic stroke or embolic stroke. Carotid intima-media thickness (IMT) is an indicator of atherosclerosis used commonly as a screening test for abnormalities of the coronary artery. 24-hour ambulatory ECG is widely used to screen for underlying diseases that causes syncope, palpitation, arrhythmia, etc. Objectives : Since both carotid IMT and 24-hour ambulatory ECG are used to screen for cardiac problems, we endeavored to explore the correlation between carotid IMT and 24-hour ambulatory ECG of stroke patients. Methods : The records of ischemic stroke patients who were admitted to Kyunghee Medical Center Oriental Hospital ward from March 2006 to May 2009 were reviewed. 28 patients who had both carotid Doppler US and 24-hour ambulatory ECG test undertaken during their admission were analyzed. The relationship of abnormal ambulatory results and common carotid artery(CCA) IMT were statistically analyzed using Fisher's exact test and t-test. Results : The mean age of the abnormal ambulatory group was older than the normal group (74${\pm}$ 8.0 vs. 61${\pm}$12.1, p=0.0098). Although insignificant, the abnormal ambulatory group showed much thicker CCA-IMT than normal ambulatory group (2.l7${\pm}$ 1.16 vs. 1.51${\pm}$0.97. p=0.l389). Conclusion: No significant correlation was observed between abnormal ambulatory results and CCA-IMT. However, the difference in CCA-IMT between the two groups was too big to be ignored and further investigation with larger and better controlled trials are warranted.
토사자가 PTU로 유발된 갑상선기능저하증 Rat에 미치는 영향
강지석,박성환,한수련,안영민,안세영,이병철,Kang, Ji-Suck,Park, Sung-Hwan,Han, Su-Ryun,Ahn, Young-Min,Ahn, Se-Young,Lee, Byung-Cheol 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3
Objectives : Hypothyroidism is a relatively common endocrinologic disease, especially among older women. Western medical doctors treat hypothyroidism with levothyroxine, however there are several side effects, including thyrotoxicosis, atrial fibrillation, osteoporosis, etc. Therefore, traditional Korean medicine(TKM) offers an appealing alternative therapy for hypothyroidism. In this study, Cuscuta Semen was used to analyze its possible effect on a hypothyroidism rat model induced by propylthiouracil(PTU). Methods : 24 two-month-old Sprague-Dawley(SD) rats were divided into 4 groups: normal (n=6), PTU-induced hypothyroidism control(n=6), hypothyroidism rat treated with Cuscuta Semen (n=6), and hypothyroidism rat treated with levothyroxine(n=6). PTU was administered for 4 weeks, Cuscuta Semen and levothyroxine was administered 2 weeks after PTU was initiated for a total duration of 2 weeks. Blood samples from all the rats were taken from their hearts and analyzed. Results : When compared to the normal group, the PTU-induced control group showed significantly lower $T_4$, $T_3$ levels and significantly higher TSH level, which is indicative of hypothyroidism. The Cuscuta Semen group had significantly higher $T_4$ and significantly lower TSH than the control group(p<0.05). There was no significant difference in biochemical labs and weight between the Cuscuta Semen and control groups. Conclusions : These results suggest that Cuscuta Semen could be effective in increasing thyroid hormone production, and be powerful enough to affect the hypothalamus-pituitary-thyroid axis. Also, no adverse effects related with Cuscuta Semen were found, suggesting that it is relatively safe to administer. In conclusion, it seems that Cuscuta Semen is a safe alternative medicine for hypothyroidism.
매체 변화에 따른 각색 양상 : 『헛간을 태우다』와 < 버닝>의 비교를 중심으로
강지석(Ji Seok KANG),이효원(Hyo Won LEE) 글로컬창의산업연구센터 2020 글로컬창의문화연구 Vol.9 No.2
현대사회에는 수많은 매체들이 독립적으로. 혹은 결합과 변형의 형태를 거쳐 공존하고 있다. 같은 이야기를 담고 있을지라도 매체가 변용되었을 때 각각의 매체적 특성으로 인해 다른 표현양상을 드러낸다. 본 논문은 무라카미 하루키의 소설 『헛간을 태우다』와 이를 각색한 이창동의 영화 <버닝>의 비교연구이다. 이창동은 소설의 액자식 구성을 일인칭 시점으로 변화시키고, 만연체의 서정성을 청춘, 막연함, 분노 등의 키워드를 추가하여 역동적으로 그려냈다. 또한 소설에 드러나지 않았던 인물들의 특성을 추가하여 캐릭터의 입체화를 이룩하였고, 한국적 정서로 변환하는 과정에서 미장센을 새롭게 구축하여 주제를 심화하였다. 이렇듯, 소설의 영화적인 확장과 변용을 심미적인 가치의 시선에서 비고 고찰한다. In modern society, numerous media are independently. Or they coexist through the form of bonding and transformation. Even if they contain the same story, when the medium is transformed, it reveals different forms of expression due to the characteristics of each medium. This thesis is a comparative study of Haruki Murakami"s novel Burn Burning and Lee Chang-dong"s adaptation of it, <Burning>. Lee Chang-dong changed the composition of the novel to a first-person perspective and dynamically expressed it by adding keywords such as youth, ambiguity, and unknown anger. In addition, by adding the characteristics of the characters that were not revealed in the novel, the character was made three-dimensional, and in the process of transforming it into a Korean sentiment, mise-en-scene was newly constructed to deepen the subject. As such, the novel"s cinematic expansion and transformation are remarked and examined from the perspective of aesthetic value.