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간세포암 환자에서 doxorubicin과 cisplatin 복합 화학 요법에 대한 제 2상 임상연구
강보리 ( Bo Lee Kang ),유영진 ( Young Jin Yuh ),김성록 ( Sung Rok Kim ),송홍석 ( Hong Suk Song ),이순남 ( Soon Nam Lee ),신동복 ( Dong Bok Shin ),안명주 ( Myung Ju Ahn ),박연희 ( Yeon Hee Park ) 대한내과학회 2005 대한내과학회지 Vol.68 No.2
목적 : 국소요법이 불가능한 진행성 간세포암 환자를 대상으로 doxorubicin과 cisplatin 복합화학요법의 효과와 안전성을 알아보기 위하여 전향적 2상 연구를 시행하였다. 방법 : 진행성 간세포암으로 근치적 국소요법이 불가능한 환자를 대상으로 연구를 진행하였다. 치료는 doxorubicin 50 ㎎/㎡과 cisplatin 100 ㎎/㎡을 각각 제 1일에 정주하였으며, 이 치료를 매 3주마다 반복하였다. 그러나 치료 독성으로 인한 사망 환자가 발 Background : There still is no standard treatment for the patients with advanced hepatocellular carcinoma. Both doxorubicin and cisplatin have modest activity with the response rates less than 20%, but have synergistic effect. This prospective phase II tr
증례 : 호흡기 ; GM-CSF 흡입치료로 호전된 폐포단백증 1예
강보형 ( Bo Hyoung Kang ),이호수 ( Ho Su Lee ),이유미 ( Yu Mi Lee ),박소은 ( So Eun Park ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),송진우 ( Jin Woo Song ) 대한내과학회 2012 대한내과학회지 Vol.82 No.3
Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of lipoproteinaceous material within the alveoli. Several studies have recently found that autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) play a major role in the pathogenesis of idiopathic PAP. Consequently, inhaled or systemic injection of GM-CSF has been suggested as a promising treatment for PAP. A 54-year-old male visited our hospital for progressive dyspnea. Four years earlier, he was diagnosed with PAP based on a surgical lung biopsy in another institution. Whole-lung lavage was performed four times before he visited our hospital. We administered high-dose inhaled GM-CSF therapy for 12 weeks followed by 12 weeks of low-dose therapy. After the GM-CSF treatment, the patient`s symptoms, lung function, and radiological findings were improved significantly. (Korean J Med 2012;82:357-361)