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Siwoo Lee,Byeongryeol Choi,Hyeongman Park 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Six kinds of insecticides, fenpropathrin, dicofol, milbemectin, tebufenpyrad, monocrotophos and propargite, were selected for investigating LC50s to local two spotted spider mite(TSSM) strains. The TSSMs were collected from peach (Cheongdo area) and apple orchards (Chungju, Kunwi and Sobo areas) in 2005, from strawberry plastic house (Nonsan and Damyang areas) in 2006 for experiment and some insecticides selected TSSM strains for more than 20 generations were also used. Each strain was clustered by LC50 value got from six selected insecticides treatment. Every insecticide showed about three-fourfold LC50 difference among TSSMs caught in same area. There are no specific differences in LC50 patterns of TSSM to insecticides within peach orchard and among apple orchards. But TSSMs of apple orchard and peach orchard were clustered into different group each other. Grouping of selected TSSM strains with insecticides in lab artificially showed good relationship between action mechanisms of insecticides. In strawberry strains TSSM showed regional differences between Damyan and Nonsan. The TSSMs of Nonsan showed more resistance to Tebyfenpyrad and Propargite, but TSSM of Damyang was more resistant to fenpropathrin than that of Nonsan. The TSSMs selected with monocrotophos and bifenazate, known as acetylcholinesterase inhibitors, and also pyridaben and chlorfenapyr, known as inhibitors of mitochondrial electron transportation, were grouped close respectively.
Park Miso S.,Lee Siwoo,Baek Younghwa,Lee Juho,Park Sang-Soo,Cho Jung-Hyo,Jin Hee-Jeong,Yoo Ho-Ryong 한국유전학회 2023 Genes & Genomics Vol.45 No.12
Background The biological clock allows an organism to anticipate periodic environmental changes and adjust its physiology and behavior accordingly. Objective This retrospective cross-sectional study examined circadian gene polymorphisms and clinical characteristics associated with insulin resistance (IR). Methods We analyzed data from 1,404 Korean adults aged 30 to 55 with no history of cancer and cardio-cerebrovascular disease. The population was classified according to sex and homeostasis model assessment of insulin resistance (HOMA-IR) values. Demographics, anthropometric and clinical characteristics, and single nucleotide polymorphisms (SNPs) were analyzed with respect to sex, age, and HOMA-IR values. We used association rule mining to identify sets of SNPs from circadian and metabolic sensing genes that may be associated with IR. Results Among the subjects, 15.0% of 960 women and 24.3% of 444 men had HOMA-IR values above 2. Most of the parameters differed significantly between men and women, as well as between the groups with high and low insulin sensitivity. Body fat mass of the trunk, which was significantly higher in insulin-resistant groups, had a higher correlation with high sensitivity C-reactive protein and hemoglobin levels in women, and alanine aminotransferase and aspartate aminotransferase levels in men. Homozygous minor allele genotype sets of SNPs rs17031578 and rs228669 in the PER3 gene could be more frequently found among women with HOMA-IR values above 2 (p = .014). Conclusion Oxidative stress enhanced by adiposity and iron overload, which may also be linked to NRF2 and PER3-related pathways, is related to IR in adulthood. However, due to the small population size in this study, more research is needed.
Considering Insecticide Resistance to Insecticides
Siwoo Lee,Sang-Guei Lee,Chang-Gyu Park,Kwang-Ho Kim,Hong-Hyun Park 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
Insecticide resistance development of insect pests is one of the main threatening factors against stable crop production and keeping human life safe from insect pest disease vector. To know properties of insecticides resistance is very important to develop a management program against insecticide resistance pests. Insecticide resistance development is an event of evolutionary process. We have to deal with insecticide resistance of insect pests by interaction between insecticide and insect pests in their chemical, physical and biological environment. We can glimpse at and infer the evolutionary process of insects from investigating and comparing the resistance level of insect pests to insecticides. Huge amount and many kinds of insecticides have been sprayed to control insect pests. Development of insecticide resistance of insect such as housefly and mosquito, known as most common medical insect, is a result of adaptation to environment covered with insecticides. We can easily assume that the amount and kind of insecticides sprayed the evolutionary force to the diversity of insecticide resistance. The resistance diversity will be very good character of good markers for determining geographical isolation.
Antifouling 표면처리된 나노 다공성 알루미나막이 적용된 췌도세포 이식용 면역억제 캡슐
조시우(Siwoo Cho),박민(Min Park),이상민(Sangmin Lee),김영애(Yeongae Kim),황운봉(Woonbong Hwang),박재성(Jaesung Park) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
For pancreatic islet transplantation, many kinds of polymeric and silicon based immunoisolation filters have been introduced to circumvent immune rejection,. However, these couldn’t show sufficient feasiblility on porosity, accurate cut-off range and bio-fouling effect by immne molecules. In this study, 14.6 nm pore anodic aluminum oxide (AAO) membrane was fabricated using covalently bonded poly-ethylene oxide (PEO), which was verified that the chosen pore diameter had selectivity to block the smallest immune molecule, immunoglobulin G (IgG), having sufficient porosity for glucose, insulin and oxygen to pass through. Also, to check antifouling, IgG adhesion was checked on PEO coated membrane and poly-ethylene glycol coated capsule and tubing components. Encapsulation system was developed using the membranes, sufficiently mantained survival and functionality of transplanted islets We expect that the AAO membrane will contribute immunoisolation in xenogeneic transplantations.
멀티미디어 저작도구를 이용한 개인교수형 과학교육용 코스웨어 구현
박시우(SiWoo Park),최한석(HanSuk Choi),김용성(YongSung Kim),장옥배(OkBae Chang) 한국정보과학회 1995 한국정보과학회 학술발표논문집 Vol.22 No.2A
본 논문은 실험 실습 기자재가 부족한 중등 학교의 과학교육의 질 향상을 위한 교수 · 학습 방법의 한 개선 방법으로 멀티미디어를 이용하여 개인교수형 간접 실험 보조수업 모형을 제안한다. 본 논문에서 구현된 내용을 과학교육용 코스웨어 중 “열현상과 분자운동”이고 고등학교 30명 학생을 대상으로 학습 효과를 분석한다. 본 논문에서 구현된 시스템에서의 교수 전략 및 화면 제시 기법에 대한 학습자들의 반응을 11개 문항으로 조사한 결과 대상 학생의 약 80% 이상이 시스템에 대한 만족감을 나타내고 있다. 멀티미디어를 이용한 과학교육용 코스웨어는 한 가지 매체를 사용한 것보다 학습 효과를 높일 수 있고 동화상 정보를 통해 간접 실험 경험을 하도록 함으로써 과학 학습에 대한 탐구 능력을 향상시킬 수 있다.
Lee, Sangmin,Park, Min,Park, Heon-Seok,Kim, Yeongae,Cho, Siwoo,Cho, Jae Hyoung,Park, Jaesung,Hwang, Woonbong Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.6
<P>Nanochannel membranes have been fabricated for many biological and engineering applications. However, due to low-throughput process, high cost, unsuitable pore geometries, and low chemical/mechanical stability, we could not have obtained optimized nanochannel membranes for biomedical treatments as well as a novel building block for artificial cell membranes. Here, we report a PEO-functionalized straight nanochannel array based on a self-organized porous alumina for a novel biofilter with antifouling, superior immunoprotection and high permeability of nutrients, which have excellent <I>in vivo</I> mechanical stability. Thus, our strategy may provide great advantages in novel membrane biotechnologies such as biofiltration, artificial cells, and drug delivery.</P> <P>Graphic Abstract</P><P>We first report optimized nanochannel biofilter with superior immunoprotection, antifouling properties and the high permeability of nutrients, which have excellent mechanical stability under <I>in vivo</I> condition. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0lc00499e'> </P>