http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Nakamura, Fumiaki,Maejima, Hiroshi,Kawamura, Midori,Arai, Daisuke,Okino, Tatsufumi,Zhao, Meng,Ye, Tao,Lee, Jungyeol,Chang, Young-Tae,Fusetani, Nobuhiro,Nakao, Yoichi Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.12
<P><B>Abstract</B></P> <P>Kakeromamide A (<B>1</B>), a new cyclic pentapeptide encompassing a thiazole ring moiety and a <I>β</I>-amino acid, was isolated from the marine cyanobacterium <I>Moorea bouillonii</I>. Its structure was elucidated by the spectral analysis and the modified Marfey’s method. Compound <B>1</B> induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new cyclic pentapeptide isolated from the marine cyanobacterium. </LI> <LI> Moderately cytotoxic against HeLa cells. </LI> <LI> Induced differentiation of neural stem cells into astrocytes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Yoichi Yano ),( Tatsuyuki Tonan ),( Yuriko Koga ),( Toru Nakamura ),( Mitsuhiko Abe ),( Yu Ikezono ),( Michio Sata ),( Takuji Torimura ),( Si Won Lee ),( Mi Hong Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Liver stiffness is sometimes occured in patient with HCV-associated to HIV-positive. Reduction of immune system, the patient might has been got HCV easily. Early detection and treatment should be done to ensure that the patient can be healed. The earlier we can detect, the higher possibility they can be cured. Therefore, nowadays researchers and clinicians focused in the development of diagnostic tools with high sensitivity and specifi city. The noninvasive measurement of liver stiffness (LS) now can be evaluated by transient elastography (fibroScan). Methods: We evaluated 35 patients with chronic viral hepatitis, 69% were male, 31% were female. We divided them into 3 groups, (1) no fi brosis group (2) mild until moderate (3) severe HCV with extensive fi brosis and liver stiffness. All subject (100%) were evaluated by fibroScan, 15 patients (43%) also got liver biopsy, and 31 patients (88%) also got MRI. Study design is cross-sectional with simple random sampling. Results: In TE, the degree of liver fi brosis were calculated by velocity of low-frequency transient wave produced by mechanical-probe. Comparing to liver biopsy, TE has demonstrated both high specifi city and sensitifi ty. The specifi cty of TE is 94.29% to (95%CI: 93.15%-96.7%) and sensitifi ty of TE is 82.85% (95% CI: 79,87%-85,76%). Conclusions: Real-time TE is a reliable surrogate marker of liver fi brosis, with high specifi city and sensitifi ty for early detection in mild fi brosis. However, the applicability of TE is limited to non-obese patients (BMI < 30 kg/m2) and without any ascites. If TE has already predicted liver fi brosis, biposy may not be necessary.
Suda, Shoya,Ishibashi, Kenji,Riyana, Eka Sapta,Aida, Yani Nur,Nakamura, Shohei,Imahayashi, Yoichi The Korean Association for Radiation Protection 2016 방사선방어학회지 Vol.41 No.4
Background: Experiments with small electrochemical apparatus were previously carried out for detecting low-energy neutrinos under irradiation of reactor neutrinos and under natural neutrino environment. The experimental result indicated that the output current of reactor-neutrino irradiated detector was appreciably larger than that of natural environmental one. Usual interaction cross-sections of neutrinos are quite small, so that they do not explain the experimental result at all. Materials and Methods: To understand the experimental data, we propose that some biological products may generate AV-type scalar field B0, leading to a large interaction cross-section. The output current generation is ascribed to an electrochemical process that may be assisted by weak interaction phenomena. Dissolved oxygen concentrations in the detector solution were measured in this study, for the purpose of understanding the mechanism of the detector output current generation. Results and Discussion: It was found that the time evolution of experimental output current was mostly reproduced in simulation calculation on the basis of the measured dissolved oxygen concentration. Conclusion: We mostly explained the variation of experimental data by using the electrochemical half-cell analysis model based on the DO concentration that is consistent to the experiment.
Acid-suppressive medication, a possible risk factor for asthma
( Yasuhiro Tomita ),( Yuma Fukutomi ),( Mari Irie ),( Kazuhiro Azekawa ),( Yoichi Nakamura ),( Chiharu Okada ),( Terufumi Shimoda ),( Miku Sano ),( Katsuyuki Kojima ),( Yoshinori Hasegawa ),( Masami T 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Acid-suppressive medication (ASM), such as proton pump inhibitors and histamine 2 receptor antagonists, are commonly used. However, concerns have been raised that they might cause allergic diseases, including asthma. We investigated the relationship between the use of ASM and the subsequent incidence of asthma. Methods: A retrospective cohort study was conducted using the data from health insurance claims and results of specific health checkups for metabolic syndrome from 3 health insurance societies April 2011-thru-March 2015. Among the 40-64-year-old subjects without asthma (5,915 men, 3,973 women), logistic regression analyses were performed to investigate the relationship between the use of ASM (stratified as none, 1-59 days/year, ≥60days/year) and subsequent incidence of asthma. The adjustment was made for age, smoking status, BMI, and registered “allergic rhinitis” and “reflux esophagitis” diagnoses in multivariate logistic regression analyses. Results: 213 (3.6%) men (median 47 [IQR, 11] years old) and 211 (5.3%) women (median 47 [IQR, 9]) developed asthma. In the whole cohort, both short- and long-term use of ASM was significantly related to asthma incidence (adjusted Odds Ratio 1.89 [95% CI, 1.40-2.57]; P <0.001, aOR 1.82 [95% CI, 1.15-2.89]; P = 0.01, respectively). In men, only short-term use of ASM was significantly related to asthma incidence (aOR 1.87 [95% CI, 1.21-2.92]; P = 0.005). In women, both short- and long-term use was significantly related to asthma incidence (aOR 1.92 [95% CI, 1.26-2.92]; P = 0.002, aOR 2.85 [95% CI, 1.50-5.40]; P = 0.001, respectively). Longer duration of ASM use was also significantly associated with asthma incidence after adjusting for confounders (P-values for trends <0.001 in women and the whole cohort). Results in subjects without registered “reflux esophagitis” were almost the same as in the main analyses. Conclusions: Acid- suppressive medication could be a risk factor for the subsequent incidence of asthma.
High Frequency of TP53 but not K-ras Gene Mutations in Bolivian Patients with Gallbladder Cancer
Asai, Takao,Loza, Ernesto,Roig, Guido Villa-Gomez,Ajioka, Yoichi,Tsuchiya, Yasuo,Yamamoto, Masaharu,Nakamura, Kazutoshi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Although genetic characteristics are considered to be a factor influencing the geographic variation in the prevalence of gallbladder cancer (GBC), they have not been well studied in Bolivia, which has a high prevalence rate of GBC. The purpose of this study was to examine the frequency of TP53 and K-ras mutations in Bolivian patients with GBC and to compare them with our previous data obtained in other high-GBC-prevalence countries, namely Japan, Chile, and Hungary. DNA was extracted from cancer sites in paraffin-embedded tissue from 36 patients using a microdissection technique. TP53 mutations at exons 5 to 8 and K-ras mutations at codons 12, 13 and 61 were examined using direct sequencing techniques. The data obtained were compared with those in the other high-GBC-prevalence countries. Of the 36 patients, 18 (50.0%) had a TP53 mutation (one mutation in each of 17 patients and three mutations in one patient), and only one (2.8%) had a K-ras mutation. Of the 20 TP53 mutations, 12 were of the transition type (60.0%). This rate was significantly lower than that in Chile (12/12, P<0.05). In addition, three mutations were of the CpG transition type (15.0%), which is a feature of endogenous mutation. All three were found in the hot spot region of the TP53 gene. In contrast, G:C to T:A transversion was found in Bolivia, suggesting the presence of exogenous carcinogens. Our findings suggest that the development of GBC in Bolivia is associated with both exogenous carcinogens and endogenous mechanisms. The identification of an environmental risk factor for GBC is needed to confirm these findings.