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Ushida, Kazunari,Hashizume, Kenta,Miyazaki, Kohji,Kojima, Yoichi,Takakuwa, Susumu Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.12
Fecal malodor is an acute environmental issue to be solved for the intensive animal agriculture in Japan. Among these substances volatile sulfur such as hydrogen sulfide (HS), methanethiol, and dimethyl sulfide, and dimethyl disulfide are the ones most strictly controlled in the Japanese national regulations. In this experiment, we have screened a range of standard strains of chemoheterotrophic bacteria and of the presently isolated soil bacteria for their capacity to decompose HS. We have demonstrated that Comamonas testosteroni $JCM5832^T$ and our isolate Bacillus sp. had a potential to reduce malodor when applied to the pig feces.
Acid-suppressive medication, a possible risk factor for asthma
( Yasuhiro Tomita ),( Yuma Fukutomi ),( Mari Irie ),( Kazuhiro Azekawa ),( Yoichi Nakamura ),( Chiharu Okada ),( Terufumi Shimoda ),( Miku Sano ),( Katsuyuki Kojima ),( Yoshinori Hasegawa ),( Masami T 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Acid-suppressive medication (ASM), such as proton pump inhibitors and histamine 2 receptor antagonists, are commonly used. However, concerns have been raised that they might cause allergic diseases, including asthma. We investigated the relationship between the use of ASM and the subsequent incidence of asthma. Methods: A retrospective cohort study was conducted using the data from health insurance claims and results of specific health checkups for metabolic syndrome from 3 health insurance societies April 2011-thru-March 2015. Among the 40-64-year-old subjects without asthma (5,915 men, 3,973 women), logistic regression analyses were performed to investigate the relationship between the use of ASM (stratified as none, 1-59 days/year, ≥60days/year) and subsequent incidence of asthma. The adjustment was made for age, smoking status, BMI, and registered “allergic rhinitis” and “reflux esophagitis” diagnoses in multivariate logistic regression analyses. Results: 213 (3.6%) men (median 47 [IQR, 11] years old) and 211 (5.3%) women (median 47 [IQR, 9]) developed asthma. In the whole cohort, both short- and long-term use of ASM was significantly related to asthma incidence (adjusted Odds Ratio 1.89 [95% CI, 1.40-2.57]; P <0.001, aOR 1.82 [95% CI, 1.15-2.89]; P = 0.01, respectively). In men, only short-term use of ASM was significantly related to asthma incidence (aOR 1.87 [95% CI, 1.21-2.92]; P = 0.005). In women, both short- and long-term use was significantly related to asthma incidence (aOR 1.92 [95% CI, 1.26-2.92]; P = 0.002, aOR 2.85 [95% CI, 1.50-5.40]; P = 0.001, respectively). Longer duration of ASM use was also significantly associated with asthma incidence after adjusting for confounders (P-values for trends <0.001 in women and the whole cohort). Results in subjects without registered “reflux esophagitis” were almost the same as in the main analyses. Conclusions: Acid- suppressive medication could be a risk factor for the subsequent incidence of asthma.
( Sarah Augustina ),( Imam Wahyudi ),( I Wayan Darmawan ),( Jamaludin Malik ),( Efrida Basri ),( Yoichi Kojima ) 한국목재공학회 2020 목재공학 Vol.48 No.4
Effect of pre-treatment and compression ratio on specific gravity (SG) and dimensional stability improvement of three lesser-used wood species from natural forest area of North Kalimantan Province, Indonesia had been investigated. Hot soaking at 80 ℃ for 3 hours within 2 and 5% of boron solution was applied as pre-treatment, while compression ratio applied was 20 and 40% from the initial thickness. Densification was conducted using hot pressing machine at 30 kg/cm<sup>2</sup> of pressure and 160 ℃ of temperature for 15 minutes. Specific gravity was measured gravimetrically, while dimensional stability was evaluated through thickness swelling and water absorption as the indicator. Results show that SG of densified wood was influenced by wood species and compression ratio, but not by pre-treatment applied; while dimensional stability was influenced by wood species, compression ratio, and pre-treatment. Specific gravity and water absorption of densified wood was improved significantly. Specific gravity increased 28.86-63.03%, while water absorption decreased 12.80-15.89%. Thickness swelling of 20% densified wood was lower than that of 40% densified wood.
Mahmood A. Hamed,Seiichi Nakata,Ramadan H. Sayed,Hiromi Ueda,Badawy S. Badawy,Yoichi Nishimura,Takuro Kojima,Noboru Iwata,Ahmed R. Ahmed,Khalid Dahy,Naoki Kondo,Kenji Suzuki 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.4
Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.