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( Pilar Brito Zeron ),( Marta Perez De Lis Novo ),( Roberto Perez Alvarez ),( Jacobo Sellares ),( Soledad Retamozo ),( Xavier Bosch ),( Fernanda Hernandez ),( Josep Manel Santos ),( Antoni Siso Almira 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To analyse the infi uence of the epidemiological profi le in the disease expression of a large series of patients with sarcoidosis. Methods: Study cohort including 160 patients diagnosed with sarcoidosis in the last 10 years. The diagnosis of sarcoidosis was based on clinical criteria and imaging studies, together with the histopathological demonstration of non-necrotizing granulomas, and excluding other granulomatous diseases, mainly infectious (tuberculosis). Results: There were 106 women and 54 men, with a mean age at diagnosis of 46.87 years. The main clinical manifestations present at diagnosis were respiratory symptoms (40%), followed by general symptoms (31%), skin lesions (29%) and the incidental fi nding of imaging fi ndings in asymptomatic patients (18%). 37% of patients had adisease onset <40 years. This early onset of disease was reported mainly in males (44% vs 28%, p=0.027) and was associated with a higher frequency of general symptoms (42% vs 25%, p=0.023), erythema nodosum (29% vs 16%, p=0.041), uveitis (14% vs. 5%, p=0.05) and joint involvement (17% vs 5%, p=0.014), but with a lower frequency of interstitial lung disease (25% vs 42%, p=0.028) and splenic involvement (0% vs 7%, p=0.037). With respect to the differential presentation of the disease according to gender, women diagnosed with sarcoidosis had a higher mean age at diagnosis (48.8 vs 42.8 years, p=0.017), a higher frequency of skin involvement (35% vs 13%, p=0.003) and a lower frequency of pulmonary (34% vs 52%, p=0.022), hepatosplenic (2% vs 9%, p=0.044) and nervous system (3% vs 13%, p=0.032) involvements in comparison with males. Conclusions: An early disease onset (<40 years) was mainly associated with general and cutaneous involvement, while sarcoidosis in men affects more frequently vital organs.
Type-specific human papillomavirus distribution in invasive cervical cancer in Korea, 1958-2004.
Oh, Jin-Kyoung,Alemany, Laia,Suh, Jung-Il,Rha, Seo-Hee,Muñ,oz, Nubia,Bosch, F Xavier,Quint, Wim,Lloveras, Belen,Klaustermeier, Jo Ellen,de Sanjosé,, Silvia,Shin, Hai-Rim Asian Pacific Organization for Cancer Prevention 2010 Asian Pacific journal of cancer prevention Vol.11 No.4
<P>To describe the HPV genotype distribution and to investigate the underlying secular trend in the relative contribution of HPV types 16-18 in invasive cervical cancer (ICC) over a period of 47 years (1958-2004) in South Korea.</P>
( Marta Perez De Lis Novo ),( Roberto Perez Alvarez ),( Soledad Retamozo ),( Pilar Brito Zeron ),( Xavier Bosch ),( Antoni Siso Almirall ),( Jaume Villalta ),( Ricardo Alvarez Vijande ),( Alfonso Lope 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To analyse the possible existence of features associated with IgG4-related disease (IgG4-RD) in patients diagnosed with retroperitoneal fi brosis or mesenteritis. Methods: Study cohort including patients diagnosed with retroperitoneal fi brosis and/ or mesenteritis by imaging studies (CT) in a university hospital during the last 20 years. Results: A total of 22 patients diagnosed with retroperitoneal fi brosis (15 patients) or mesenteritis (7 patients) are described (6 women and 16 men, with a mean age at diagnosis of 64.1 years, range: 46-82. The main clinical manifestations present at diagnosis were abdominal/back pain (n=14), general malaise/fever (n=7) and the presence of edema/thrombosis (n = 6); in one patient, diagnosis was made incidentally by imaging techniques. CT showed infl ammatory masses affecting retroperitoneal (n=17), mesenteric (n=7) and vascular structures, including iliac arteries (n=3), aorta (n=2), renal arteries (n=2) and cava (n=2). In 7 (32%) patients, involvement of other organs suggestive of IgG4-RD (liver/bile tract in 2 cases, periaortitis in 2 cases, pleura, lymph nodes and skin in 1 each, respectively) was found. Diagnosis was confi rmed by biopsy in 8 patients (36%); in any patient, studies to rule out IgG4-RD were performed. The main treatments included corticosteroids (n=17), immunosuppressive agents (azathioprine in 5, methotrexate in 1 and mycophenolate in 1), surgery (n = 5) and the placement of urinary catheters (n = 4). After a mean follow-up of 73 months, 7 patients died (32%) patients (4 of them due to septic shock). Conclusions: Ormond`s disease is a rare clinical entity but associated with a signifi cant morbidity and mortality. His recent inclusion in the clinical spectrum of IgG4-RD diffi cult their retrospective diagnosis, although this study and others recently published suggest that about half of the cases could correspond to IgG4-RD.
Should Male Circumcision be Advocated for Genital Cancer Prevention?
Morris, Brian J.,Mindel, Adrian,Tobian, Aaron A.R.,Hankins, Catherine A.,Gray, Ronald H.,Bailey, Robert C.,Bosch, Xavier,Wodak, Alex D. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
The recent policy statement by the Cancer Council of Australia on infant circumcision and cancer prevention and the announcement that the quadrivalent human papillomavirus (HPV) vaccine will be made available for boys in Australia prompted us to provide an assessment of genital cancer prevention. While HPV vaccination of boys should help reduce anal cancer in homosexual men and cervical cancer in women, it will have little or no impact on penile or prostate cancer. Male circumcision can reduce cervical, penile and possibly prostate cancer. Promotion of both HPV vaccination and male circumcision will synergistically maximize genital cancer prevention.
( Pilar Brito Zeron ),( Hoda Gheitasi ),( Marta Perez De Lis Novo ),( Noelia Armiger ),( Maria Jose Soto Cardenas ),( Myriam Gandia ),( Albert Bove ),( Xavier Bosch ),( Soledad Retamozo ),( Miriam Aka 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To investigate the mechanisms involved in lymphocyte activation mediated by the CD5 immunoreceptor in patients with systemic autoimmune diseases related to B-cell hyperactivity. Methods: A total of 508 patients were analyzed (273 primary Sjogren syndrome patients, 135 SLE patients, 47 SS associated HCV patients and 53 controls). CD5 genotyping receptor was analyzed by PCR-SBT technique with the detection of the SNP7 (rs2241002) andSNP26 (rs2229177). The homozygous haplotype CC/CC was classifi ed as inductor of autoimmunity, whereas the heterozygous haplotype CC/TT was a protective factor. Results: The haplotype CC/CC was found in 7.5% of controls vs 19% of patients with primary SS fulfi lling the 2002 criteria (p=0.047), 12% of SS-1993 criteria (p=0.39), 18% of SLE (p=0.10) and 21% of SS-HCV patients (p=0.049); the protective haplotype CC/TT was observed in 28% of controls vs 19% of patients with primary SS-2002 criteria (p=0.15), 13% of SS-1993 criteria (p=0.01), 15% of SLE (p=0.04) and 15% of SS-HCV patients (p=0.10). A specifi c analysis was carried out in patients with primary SS-2002 criteria comparing the clinical and immunological features of patients carrying protective haplotypes (n=33) and those carrying inductor haplotypes (n=33). A higher frequency of anti-La/SS-B antibodies (67% vs 39%, p=0.048) and a trend for an increased frequency of extraglandular involvement (52% vs 36%), neutropenia (33% vs 18%), ANA (91% vs 82%), FR (53% vs 48%) and low levels of C3 (12% vs 3%) was found in carriers of inductor haplotypes with respect to those carrying protective haplotypes. Conclusions: We found a higher frequency of the CC/CC haplotype (associated with increased autoimmunity) of the gene that encodes the immunoreceptor lymphocytic CD5 in SS patients, that was related to an increased extraglandular systemic activity, especially a higher frequency of anti-La/SS-B antibodies.