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Jung Yoon Suk,Kim Sunyong,Kim Hyun-Young,Noh Seung Jae,Park Jung Ho,Sohn Chong Il,Park Chan Hyuk 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.5
Background/Aims: Tegoprazan, a new, fast, and strong potassium-competitive acid blocker, has been approved for the treatment of gastric acid-related diseases in Korea. However, realworld clinical data regarding this drug are scarce. We aimed to compare the Helicobacter pylori eradication rates of tegoprazan- and rabeprazole-based triple therapy. Methods: We retrospectively reviewed data from patients who received first-line treatment for H. pylori infection using tegoprazan- or rabeprazole-based triple therapy for 2 weeks (50 mg tegoprazan or 20 mg rabeprazole+1,000 mg amoxicillin+500 mg clarithromycin twice daily). The primary endpoint was the eradication rate as determined by intention-to-treat analysis. Results: Of the 677 patients included in our study, 344 and 333 received tegoprazan-based and rabeprazole-based triple therapy, respectively. The eradication rate from intention-to-treat analysis was 76.7% (95% confidence interval [CI], 72.1% to 81.0%) for tegoprazan-based triple therapy and 75.4% (95% CI, 70.5% to 79.8%) for rabeprazole-based triple therapy. There was no significant difference in the eradication rates between the two groups (p>0.999). Per-protocol analysis also revealed no significant difference between the eradication rates of the two groups (tegoprazan 83.4% [95% CI, 79.0% to 87.2%] vs rabeprazole 83.5% [79.0% to 87.4%], p>0.999). Furthermore, there was no significant difference in adverse event rates between the two groups (tegoprazan, 27.6%; rabeprazole, 25.8%; p=0.604). Conclusions: The eradication rate of tegoprazan-based triple therapy was similar to that of rabeprazole-based triple therapy. Further studies on the dose-escalation effect of tegoprazan for H. pylori eradication and the efficacy of tegoprazan in regimens other than conventional triple therapy are needed.
Nanoparticle Deposition of Al<sub>2</sub>O<sub>3</sub> Powders on Various Substrates
Song, Woojin,Jung, Kyubong,Chun, Doo-Man,Ahn, Sung-Hoon,Lee, Caroline Sunyong The Japan Institute of Metals 2009 MATERIALS TRANSACTIONS Vol.50 No.11
<P>Al<SUB>2</SUB>O<SUB>3</SUB> powders of 100 nm diameter were deposited on Al, Cu, and Si substrates using a micro-nozzle in nano-particle deposition system (NPDS). This procedure allowed the production of fine-scale depositional patterns or templates not possible using conventional semiconductor processing techniques. For a given set of depositional conditions, the Al<SUB>2</SUB>O<SUB>3</SUB> powder layers developed different thicknesses on different substrates. Following deposition, the powders were sintered to provide ceramic layers. In the first instance, the depositional behavior of Al<SUB>2</SUB>O<SUB>3</SUB> was determined by Stokes number, where a number greater than 1 meant that more powder was deposited. However, the extent of deposition was also influenced by substrate type, where a Si substrate yielded the thickest powder layer. This phenomenon was related to both substrate hardness and melting temperature. Most powder particles fragmented on impact (with pieces deposited on the substrate) when substrate hardness was high. In addition, when the melting temperature of a substrate was low, more powder accumulated as a result of the kinetic energy of a colliding powder particle being transformed into heat. The Al substrate, with its relatively low melting point, developed a thicker powder deposit than those formed on Cu. Therefore, hardness and melting temperature of substrates are the key parameters influencing the depositional behavior of powders.</P>
Choi, Dahyun,Pyo, Youngjun,Jung, Seung-Boo,Kim, Yongil,Yoon, Eric H.,Lee, Caroline Sunyong JAPAN INSTITUTE OF METALS 2016 MATERIALS TRANSACTIONS Vol.57 No.7
<P>Graphene has attracted much recent interest as an electronic material due to its large electron mobility. Large-area graphene has been synthesized using chemical vapor deposition (CVD). however, it is difficult to apply this process to grow graphene on nanoparticles (NPs) because of their small radius of curvature, which results in a large defect density. In this work, we used the Taguchi method to optimize the deposition of graphene on nanoparticles. We used polyvinylpyrrolidone (PVP) to coat copper NPs via CVD and optimized the process conditions using a minimal number of experiments. The PVP served as the solid carbon source, forming graphene when heated to 875 degrees C. To improve the quality of the graph one coatings on the Cu NPs, the following process parameters wore Ng-tried: gas conditions (ratio of Ar to H-2), process time and temperature, the amount of PVP solution, and the molecular weight of PVP. We identified optimal process conditions using only eight experiments. Raman spectroscopy was used to analyze the quality of the graphene coatings by comparing two-dimensional (20) spectra and I-D/I-G ratios of the different coatings. A decrease in I-D/I-G, in combination with sharper Raman bands, is indicative of the thickness and crystal quality of the graphene layer. The quality of the graphene layer was also evaluated using transmission electron microscopy (TEM) and scanning electron microscopy (SUM). The optimal conditions for the formation of graphene-coated Cu NPs were: a temperature of 875 degrees C, a deposition time of 2 minutes, an Ar-to-H-2 ratio of 1:1, PVP with a molecular weight of M-w = 3,500 (K-12) during the polyol process, and a 50-wt.% PVP solution with M-W = 45,000 (K-30). Using the Taguchi method, we identified trends relating defect density versus process conditions and successfully obtained a graphene coating with a minimal defect density.</P>
Correlation of preoperative biomarkers with severity of adhesion in endometriosis
( Yoojung Lee ),( Yaeheun Lee ),( Seungho Lee ),( Sunyong Jung ),( Seungjoo Chon ),( Daun Jung ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: This study was undertaken to evaluate the preoperative correlation of serum markers and pelvic adhesions in endometriosis patients, and to explore their clinical value for prediction. Methods: A total of 152 women who underwent surgery for endometriosis were reviewed retrospectively. Preoperative basic serum laboratory test and CA 125 were analyzed, and the adhesion score calculated. The group with less than 28 points was defined as a mild adhesion group, and a score of 28 or more as a severe adhesion group. Results: CA 125 was significantly higher in severe adhesion group than mild adhesion group (P = 0.003). The statistically significant risk factors for adhesion were CA 125 35 U/mL (OR [odds ratio], 5.362; 95% CI [confidence interval], 2.519 - 11.415; P < 0.001), size of largest cyst 5 cm (OR, 2.626; 95% CI, 1.104 - 6.241; P = 0.029), and WBC 5,680 /L (OR, 2.279; 95% CI, 1.025 - 5.065; P = 0.043). The adhesion score was significantly higher in the CA 125 35 U/mL group than the CA 125 < 35 U/mL group (P < 0.001). Conclusion: CA 125, size of largest cyst and WBC are associated with pelvic adhesions. In particular, CA 125 was the most significant factor. Patients with preoperative CA 125 higher than 35 U/mL are at high risk for pelvic adhesion.
Kim, Min-Saeng,Chun, Doo-Man,Choi, Jung-Oh,Lee, Jong-Cheon,Kim, Yang Hee,Kim, Kwang-Su,Lee, Caroline Sunyong,Ahn, Sung-Hoon American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.4
<P>TiO2 powders were deposited on indium tin oxide (ITO) coated polyethylene terephthalate (PET) substrates for application to the photoelectrode of a dye-sensitized solar cell (DSSC). In the conventional DSSC manufacturing process, a semiconductor oxide such as TiO2 powder requires a sintering process at higher temperature than the glass transition temperature (T-g) of polymers, and thus utilization of flexible polymer substrates in DSSC research has been constrained. To overcome this restriction related to sintering, we used a nanoparticle deposition system (NPDS) that could produce a thin coating layer through a dry-spray method under atmospheric pressure at room temperature. The powder was sprayed through a slit-type nozzle having a 0.4 x 10 mm(2) rectangular outlet. In order to determine the deposited TiO2 thickness, five kinds of TiO2 layered specimens were prepared, where the specimens have single and double layer structures. Deposited powders on the ITO coated PET substrates were observed using FE-SEM and a scan profiler The thicker TiO2 photoelectrode with a DSSC having a double layer structure showed higher energy efficiency than the single layer case. The highest fabricated flexible DSSC displayed a short circuit current density J(sc) = 1.99 mA cm(-2), open circuit voltage V-oc = 0.71 V, and energy efficiency eta = 0.94%. These results demonstrate the possibility of utilizing the dry-spray method to fabricate a TiO2 layer on flexible polymer substrates at room temperature under atmospheric pressure.</P>
A Photovoltaic Power Management System using a Luminance-Controlled Oscillator for USN Applications
Ji-Eun Jeong,Jun-Han Bae,Jinwoong Lee,Caroline Sunyong Lee,Jung-Hoon Chun,Kee-Won Kwon 대한전자공학회 2013 Journal of semiconductor technology and science Vol.13 No.1
This paper presents a power management system of the dye-sensitized solar cell (DSSC) for ubiquitous sensor network (USN) applications. The charge pump with a luminance-controlled oscillator regulates the load impedance of the DSSC to track the maximum power point (MPP) under various light intensities. The low drop-out regulator with a hysteresis comparator supplies intermittent power pulses that are wide enough for USN to communicate with a host transponder even under dim light conditions. With MPP tracking, approximately 50% more power is harvested over a wide range of light intensity. The power management system fabricated using 0.13 μm CMOS technology works with DSSC to provide power pulses of 36 μA. The duration of pulses is almost constant around 80 μs (6.5 nJ/pulse), while the pulse spacing is inversely proportional to the light intensity.
( Sang Hyun Park ),( Soo Hyeon Noh ),( Jin Kyung Chae ),( Sunyong Kwon ),( Eun Jung Kim ),( Kun Park ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: A pincer nail is characterized by the presence of an excessively curved and distorted nail across the transverse dimension. A multitude of therapeutic modalities has been implemented to treat this condition with limited efficacy. Objectives: We sought to evaluate the efficacy of surgery of a pincer nail deformity with the use of the nail bed widening, partial matrixectomy and/or osteophyte removal. Methods: Nine patients (four patients : both great toe nails, five patients : single toe nail) with pincer nail deformities were treated with the nail bed widening, partial matrixectomy and/or osteophyte removal. Objective assessment was evaluated by use of the width index (width of the nail tip/width of the nail root) and height index (height of the nail tip/width of the nail tip). Subjective assessment was evaluated by use of a visual analogue scale declared by patients. In addition, wound complications and recurrence were described. Results: The width index and height index were improved (width index: 66.7%→87.5%, height index: 27.3%→0%). Relief of pain could be determined in 100% of the cases. There was no recurrence during a 3 to 17 month period (mean time: 8.8 months). Conclusion: The nail bed widening, partial matrixectomy and/or osteophyte removal as a surgical approach might be effective and more curative method for a pincer nail deformity.