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- 저자 : ( Shi Ning Cai ) (검색결과 3 건)
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Yiyu Shi,Leilei Xu,Mindong Chen,Bo Yang,Ge Cheng,Cai-e Wu,Zhichao Miao,Ning Wang,Xun Hu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
In this work, the uniform Cu2O submicron-cubes were facilely synthesized by liquid phase reductionmethod. Then, the Cu2O submicron-cubes were further oxidized into Cu2O-CuO heterojunction with tunableCu2+/Cu+ ratios and CuO submicron-cubes by controlling the calcination temperature. The phasetransition period during calcination was real-time monitored by the in-situ XRD and in-situ DRIFTS. The obtained materials were investigated as the catalysts of CO oxidation. The results revealed thatthe Cu2O-CuO heterojunction catalysts performed much higher catalytic activities than the Cu2O andCuO counterparts. Because the synergistic effect of the heterojunction (Cu2+/Cu+) could increase the surfaceoxygen vacancy concentration. Furthermore, it was also found that only the Cu2O-CuO heterojunctionstructure with the appropriate Cu2+/Cu+ ratio behaved the optimum catalytic activity. The kineticstudies indicated that the apparent activation energy of CO oxidation was greatly affected by the Cu2+/Cu+ ratio. Therefore, these Cu2O-CuO submicron-cubes with heterostructure were considered as thepromising CO oxidation catalysts.
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Zhang, Shai-Lin,Mao, Ning-Fang,Sun, Jun-Ying,Shi, Zhi-Cai,Wang, Bing,Sun, Yong-Jian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objective: To evaluate the predictive value of glutathione S-transferase (GST) gene polymorphisms for the prognosis of osteosarcoma patients receiving chemotherapy. Methods: A total of 159 patients were included in our study between January 2005 and December 2007., with follow-up until January 2012. Genotyping was based upon the duplex polymerase-chain-reaction with the PCR-CTPP method. Results: At the time of diagnosis, 15.4% of the patients presented with metastasis, while 22.3% developed metastasis during follow-up. At the time of final analysis on January 2012, the median follow-up was 45.5 months. Patients with null GSTM1 and GSTT1 had a higher event free survival rate than non-null genotype, but no significant association was found between the two genotypes and prognosis of osteosarcoma. Individuals with GSTP1 Val/Val genotype tended to live shorter than with the IIe/IIe genotype, and we found a significantly higher risk of death from osteosarcoma (adjusted HR=2.35, 95% CI=1.13-4.85). Conclusion: The GSTP1 gene polymorphism may have an important role in the prognosis of osteosarcoma patients with chemotherapy. Further analyses with larger samples and more genes encoding metabolizing and DNA repair enzymes are warranted.
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( Ping Chen ),( Yang Chen ),( Ya Rong Wang ),( Shi Ning Cai ),( Liang Deng ),( Jia Liu ),( Hao Zhang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (140 mg/kg b.w.) once daily for 7 days with CCl4. Hepatoprotective properties were evaluated by biochemical parameters: Administration of geniposide, crocins, crocin-1and crocetin significantly lowered serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) levels in CCl4-treated mice. The reduced glutathione (GSH) levels and antioxidant enzymes (SOD and CAT) activities were also increased by geniposide, crocins, crocin-1 and crocetin. Histopathological examination of livers showed that these components reduced deformability, irregular arrangement and rupture of hepatocyte in CCl4-treated mice. These biochemical results and liver histopathological assessment demonstrated that geniposide, crocetin derivatives and crocetin show comparative beneficial effects on CCl4-induced liver damage via induction of antioxidant defense. Therefore, contents of geniposide and crocetin derivatives should be both considered for hepatoprotective efficacy of Gardenia jasminoides Ellis.
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