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Pulsed low-dose rate radiotherapy for recurrent bone sarcomas: case reports and brief review
Ru Xin Wong(Ru Xin Wong ),Zubin Master(Zubin Master ),Eric Pang(Eric Pang ),Valerie Yang(Valerie Yang ),Wen Shen Looi(Wen Shen Looi ) 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Purpose: Re-irradiation for bulky recurrent sarcoma carries significant risks. Pulsed low-dose rate radiotherapy (PLDR) is an attractive option for re-irradiation due to inherent radiobiological advantages. Materials and Methods: We present two patients who underwent re-irradiation using PLDR technique, followed by a literature review. Results: The first case is that of a 76-year-old male who developed an in-field recurrence of a bulky pelvic bone high-grade chondrosarcoma after he was treated with definitive radiotherapy using helical TomoTherapy with a total dose of 66 Gy. The patient was re-irradiated using PLDR with a shrinking field technique; 50 Gy in 2 Gy fractions followed by a boost of 20 Gy in 2 Gy fractions. The patient remains disease-free without significant toxicity 60 months post-irradiation. The second case is that of an 82-year-old female who was treated with a definitive irradiation of 66 Gy in 33 fractions for a right shoulder grade II chondrosarcoma. She developed an in-field recurrence 28 months later and presented with bulky disease causing brachial plexopathy and lymphedema. The patient was re-irradiated with a palliative intent to a total dose of 50 Gy in 2 Gy fractions over 5 weeks using PLDR. Brachial plexopathy resolved shortly after re-irradiation, but local progression near the surface was evident 8 months later. She passed away from unrelated causes 11 months later. Conclusion: We present two cases highlighting our early experience with PLDR, which was effective in the re-irradiation of recurrent bony sarcoma. Our study highlights PLDR as an option for re-irradiation in recurrent unresectable tumors.
Research on Tangential Magnetization Parallel Magnetic Path Hybrid Excitation Synchronous Machine
Pang Liang,Zhao ChaoHui,Shen HeBiao 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.5
A hybrid excitation motor with strong magnetizing ability is proposed. To solve the existing hybrid excitation machine problems, such as the diffi culty of total adjustment of air gap magnetic fi eld, many additional magnetic paths, fault tolerance is poor, and Air gap fl ux density harmonic distortion rate is high. According to the structural characteristics and the principle of magnetic regulation of tangential magnetization parallel magnetic path hybrid excitation synchronous machine. The equivalent magnetic path model of the motor was established, and the infl uence of electric excitation magnetic potential on permanent magnetic potential and air gap magnetic fi eld was analyzed. With the ANSYS Maxwell fi nite element simulation software, the variation law of the magnetic fi eld of the motor under diff erent excitation conditions is studied. The infl uence of pole boot length and magnetic pole eccentricity on air gap fl ux density amplitude and harmonic distortion rate is discussed. The results show that due to the characteristics of the parallel magnetic path. The motor has obvious eff ect of adjusting magnetic fi eld and gathering magnetic fi eld, motor fault tolerance is excellent, and less additional magnetic path. In addition, the air gap density can be optimized by using reasonable pole boot length and magnetic pole eccentricity.
Gallic Acid Ameliorates Cognitive Impairment Caused by Sleep Deprivation through Antioxidant Effect
Pang Xiaogang,Xu Yifan,Xie Shuoxin,Zhang Tianshu,Cong Lin,Qi Yuchen,Liu Lubing,Li Qingjun,Mo Mei,Wang Guimei,Du Xiuwei,Shen Hui,Li Yuanyuan 한국뇌신경과학회 2023 Experimental Neurobiology Vol.32 No.4
Sleep deprivation (SD) has a profound impact on the central nervous system, resulting in an array of mood disorders, including depression and anxiety. Despite this, the dynamic alterations in neuronal activity during sleep deprivation have not been extensively investigated. While some researchers propose that sleep deprivation diminishes neuronal activity, thereby leading to depression. Others argue that short-term sleep deprivation enhances neuronal activity and dendritic spine density, potentially yielding antidepressant effects. In this study, a two-photon microscope was utilized to examine the calcium transients of anterior cingulate cortex (ACC) neurons in awake SD mice in vivo at 24-hour intervals. It was observed that SD reduced the frequency and amplitude of Ca2+ transients while increasing the proportions of inactive neurons. Following the cessation of sleep deprivation, neuronal calcium transients demonstrated a gradual recovery. Moreover, whole-cell patch-clamp recordings revealed a significant decrease in the frequency of spontaneous excitatory post-synaptic current (sEPSC) after SD. The investigation also assessed several oxidative stress parameters, finding that sleep deprivation substantially elevated the level of malondialdehyde (MDA), while simultaneously decreasing the expression of Nuclear Factor erythroid 2-Related Factor 2 (Nrf2) and activities of Superoxide dismutase (SOD) in the ACC. Importantly, the administration of gallic acid (GA) notably mitigated the decline of calcium transients in ACC neurons. GA was also shown to alleviate oxidative stress in the brain and improve cognitive impairment caused by sleep deprivation. These findings indicate that the calcium transients of ACC neurons experience a continuous decline during sleep deprivation, a process that is reversible. GA may serve as a potential candidate agent for the prevention and treatment of cognitive impairment induced by sleep deprivation.
Pang, Shengli,Su, Yanjing,Yang, Gongmei,Shen, Xiangqian,Zhu, Meng,Wu, Xiao,Li, Songwei,Yang, Xiaofen,Xi, Xiaoming Elsevier 2018 Ceramics international Vol.44 No.17
<P><B>Abstract</B></P> <P>Exploring advanced cathode materials that have high electrochemical activity and superior thermal compatibility with other components is of great importance for the application of intermediate-temperature solid oxide fuel cells. In the present study, influences of Ca doping on electrochemical and physicochemical properties of NdBa<SUB>1-x</SUB>Ca<SUB>x</SUB>CoCuO<SUB>5+δ</SUB> were studied systematically. A relatively low thermal expansion coefficient (16.8 × 10<SUP>−6</SUP> °C<SUP>−1</SUP>) was obtained for the Ca-doped sample over the temperature range of 25–800 °C. Moreover, Ca doping significantly enhanced the electrochemical performance of NdBa<SUB>1-x</SUB>Ca<SUB>x</SUB>CoCuO<SUB>5+δ</SUB>. The highest densities of power for NdBa<SUB>1-x</SUB>Ca<SUB>x</SUB>CoCuO<SUB>5+δ</SUB>-based single cells at the temperatures of 800 °C increased from 1.42 W cm<SUP>−2</SUP> for x = 0.0 to 1.84 W cm<SUP>−2</SUP> for x = 0.3. This increase in electrochemical performance of NdBa<SUB>1-x</SUB>Ca<SUB>x</SUB>CoCuO<SUB>5+δ</SUB> cathode with Ca doping can be ascribed to enhanced concentrations of oxygen vacancies and higher electrical conductivity.</P>
3-Deazaneplanocin A is a Promising Therapeutic Agent for Ovarian Cancer Cells
Shen, Liang,Cui, Jing,Pang, Ying-Xin,Ma, Yan-Hui,Liu, Pei-Shu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: Recent studies have shown that 3-deazaneplanocin A (DZNep), a well-known histone methyltransferase inhibitor, disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma. However, little is known about effects of DZNep on ovarian cancer cells. Materials and Methods: We here therefore studied DZNep-treated A2780 ovarian cancer cells in vitro. Proliferation of ovarian cancer cells under treatment of DZNep was assessed by MTT and apoptosis by flow cytometry. Cell wound healing was applied to detect the migration. Finally, we used q-PCR to assess the migration-related gene, E-cadherin. Results: DZNep could inhibit the proliferation of A2780 and induce apoptosis Furthermore, it inhibited migration and increased the expression of E-cadherin (P<0.05). Conclusion: DZNep is a promising therapeutic agent for ovarian cancer cells, with potential to inhibite proliferation, induce apoptosis and decrease migration.
A QUASI-NEWTON BUNDLE METHOD BASED ON APPROXIMATE SUBGRADIENTS
Jie, Shen,Pang, Li-Ping 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1
In this paper we propose an implementable method for solving a nonsmooth convex optimization problem by combining Moreau-Yosida regularization, bundle and quasi-Newton ideas. The method we propose makes use of approximate subgradients of the objective function, which makes the method easier to implement. We also prove the convergence of the proposed method under some additional assumptions.
( Qianqian Pang ),( Yuming Wang ),( Mingyuan Xu ),( Jiachao Xu ),( Shengquan Xu ),( Yichen Shen ),( Jinghong Xu ),( Rui Lei ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.3
Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids. [BMB Reports 2019; 52(3): 202-207]
Wu, Weisheng,Pang, Yongzhen,Shen, Guo-An,Lu, Jie,Lin, Juan,Wang, Jin,Sun, Xiaofen,Tang, Kexuan Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.2
In many organisms, trehalose acts as protective metabolite against harsh environmental stresses, such as freezing, drought, nutrient starvation, heat and salt. Herein a cDNA (designated as GbTPS, GenBank Accession Number AY884150) encoding a trehalose-6-phosphate synthase homologue was isolated and characterized from the living fossil plant, Ginkgo biloba, which is highly tolerant to drought and cold. GbTPS encoded an 868-amino-acid polypeptide with a predicted isoelectric point of 5.83 and molecular mass of 97.9 kD. Amino acid sequence alignment revealed that GbTPS shared high identity with class II trehalose-6-phosphate synthase homologues (67% identical to AtTPS7), but had only 17% and 23% of identity with OstA from Escherichia coli and ScTPS1 from S. cerevisiae, respectively. DNA gel blot analysis indicated that GbTPS belonged to a small multi-gene family. The expression analysis by RT-PCR showed that GbTPS expressed in a tissue-specific manner in G biloba and might involve in leaf development. GbTPS was also found to be induced by a variety of stresses including cold, salt, drought and mannitol.